LEADER 04074nam 22006735 450 001 9910624318503321 005 20251113201648.0 010 $a3-031-15305-7 024 7 $a10.1007/978-3-031-15305-1 035 $a(MiAaPQ)EBC7130119 035 $a(Au-PeEL)EBL7130119 035 $a(CKB)25264907100041 035 $a(DE-He213)978-3-031-15305-1 035 $a(PPN)26634920X 035 $a(EXLCZ)9925264907100041 100 $a20221101d2023 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aVaricella-zoster Virus $eGenetics, Pathogenesis and Immunity /$fedited by Ann M. Arvin, Jennifer F. Moffat, Allison Abendroth, Stefan L Oliver 205 $a1st ed. 2023. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2023. 215 $a1 online resource (276 pages) 225 1 $aCurrent Topics in Microbiology and Immunology,$x2196-9965 ;$v438 311 08$aPrint version: Arvin, Ann M. Varicella-Zoster Virus Cham : Springer International Publishing AG,c2022 9783031153044 320 $aIncludes bibliographical references. 327 $aVaricella-zoster Virus - Genetics, Molecular Evolution, and Recombination -- The structures and functions of VZV glycoproteins -- Modulation of apoptosis and cell death pathways by Varicella zoster virus -- Modulation of host cell signaling pathways by varicella-zoster virus -- Modulation of MHC and MHC-like molecules by Varicella Zoster Virus -- Varicella Zoster Virus Neuronal Persistence and Reactivation modeled in-vitro -- Humanized Severe Combined Immunodeficient (SCID) Mouse Models for Varicella-Zoster Virus Pathogenesis -- Simian Varicella Virus: Molecular Virology and mechanisms of pathogenesis -- A guide to preclinical models of zoster-associated pain and postherpetic neuralgia -- Immune Responses to Varicella-Zoster Virus Vaccines -- Common features between stroke following varicella in children and stroke following herpes zoster in adults. 330 $aThis edited volume provides insights about the molecular virology, pathoenesis of infection and host responses to varicella-zoster virus, which is a medically important human herpesvirus. The chapters not only discuss genetics and molecular evolution of the virus, but also new structure-based knowledge on the functions of viral glycoproteins. Further, the authors illustrate how mechanisms from the virus are used to take over and remodel host cells during pathogeneis. These mechanisms also enable viral modulation of host cells and evasion of the host immune response. Part of these evasion and survival strategies, is the reaction to triggered host cell responses like autophagy, the stress response, modulation of apoptosis and other cell death pathways. This hands-on knowledge is crucial for students and clinicians in Virology, Immunology, and Infectious Diseases. Chapter "Common features between stroke following varicella in children and stroke following herpes zoster in adults" is available open access under a Creative Commons Attribution 4.0 International License via Springerlink.com. 410 0$aCurrent Topics in Microbiology and Immunology,$x2196-9965 ;$v438 606 $aVirology 606 $aImmunology 606 $aHuman physiology 606 $aVaccines$xBiotechnology 606 $aBiomaterials 606 $aVirology 606 $aImmunology 606 $aHuman Physiology 606 $aBiomaterials-Vaccines 615 0$aVirology. 615 0$aImmunology. 615 0$aHuman physiology. 615 0$aVaccines$xBiotechnology. 615 0$aBiomaterials. 615 14$aVirology. 615 24$aImmunology. 615 24$aHuman Physiology. 615 24$aBiomaterials-Vaccines. 676 $a016.35960973 676 $a579.2434 702 $aArvin$b Ann M. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910624318503321 996 $aVaricella-zoster virus$93065678 997 $aUNINA