LEADER 04942nam 22007215 450 001 9910624309903321 005 20251009103400.0 010 $a3-031-08881-6 024 7 $a10.1007/978-3-031-08881-0 035 $a(MiAaPQ)EBC7133434 035 $a(Au-PeEL)EBL7133434 035 $a(CKB)25299348800041 035 $a(PPN)266354556 035 $a(DE-He213)978-3-031-08881-0 035 $a(OCoLC)1351750849 035 $a(EXLCZ)9925299348800041 100 $a20221107d2022 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aVoltage-Gated Calcium Channels /$fedited by Gerald Werner Zamponi, Norbert Weiss 205 $a1st ed. 2022. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2022. 215 $a1 online resource (705 pages) 225 1 $aPhysics and Astronomy Series 311 08$aPrint version: Zamponi, Gerald Werner Voltage-Gated Calcium Channels Cham : Springer International Publishing AG,c2022 9783031088803 320 $aIncludes bibliographical references and index. 327 $a1. Measuring and manipulating calcium -- 2. Structure, function and subunit assembly of VGCC -- 3. Splice variation and RNA editing of VGCCs -- 4. Mechanisms of calcium channel permeation -- 5. Regulation by beta subunits -- 6. Regulation by alpha2 delta subunits -- 7. VGCCs in invertebrates -- 8. Modulation by GPCRs and second messengers -- 9. Trafficking of VGCCs -- 10. Calcium regulation -- 11. Calcium channel complexes with other channels -- 12. Regulation of gene transcription by VGCCs -- 13. Lessons from knock-out and knock-in mice -- 14. VGCCs and synaptic transmission -- 15. Cardiovascular syste -- 16. Calcium channels and exocytosis in chromaffin cells -- 17. Calcium channels in the pancreas in health and disease -- 18. Skeletal muscle system -- 19. Auditory and visual systems -- 20. Calcium channels and pain transmission -- 21. Migraine -- 22. Epilepsy -- 23. Psychiatric disorders -- 24. Parkinson?s disease.-25. Reproductive system -- 26. Cancer -- 27. Molecular determinants of VGCC pharmacology -- 28. Interactions with peptide toxins -- 29. Clinical pharmacology and drug discovery. 330 $aThis book covers the tremendous progress in the current understanding of the molecular physiology of voltage-gated calcium channels. This book includes unparalleled insights into structural features of calcium channels due to X-ray crystallography and cryo-EM, which in turn yielded critical information into how these channels function under normal and pathophysiological conditions, and how they interact with calcium channel therapeutics. The chapters investigate how, with the advent of high throughput genome sequencing, numerous mutations in various calcium channel genes have been identified in patients with neurological, cardiovascular, neuropsychiatric and other disorders. This is further complemented through a much larger in vivo toolkit such as knock-out and knock-in mice. The chapters further discuss the increased complexity of calcium channel physiology that arises from mRNA editing and splicing. Finally, the book also provides an overview of the updated research on calcium channel inhibitors that can be used both in vivo and in vitro, and which may serve as a spring board for new calcium channel therapeutics for human disease. Voltage-Gated Calcium Channels is useful for academic researchers at all levels in neuroscience, biophysics, cell biology and drug discovery. Provides a comprehensive update on the state of knowledge of voltage-gated calcium channels; Examines how calcium channels are pharmacologic targets in the treatment of epilepsy, hypertension, and pain; Explores the new, sophisticated imaging approaches that have increased our ability to measure calcium in live cells; Presents an understanding of the molecular mechanisms that govern calcium channel trafficking and distribution. 410 0$aPhysics and Astronomy Series 606 $aCytology 606 $aNeurosciences 606 $aHuman physiology 606 $aBiophysics 606 $aPharmacology 606 $aCell Biology 606 $aNeuroscience 606 $aHuman Physiology 606 $aBiophysics 606 $aPharmacology 615 0$aCytology. 615 0$aNeurosciences. 615 0$aHuman physiology. 615 0$aBiophysics. 615 0$aPharmacology. 615 14$aCell Biology. 615 24$aNeuroscience. 615 24$aHuman Physiology. 615 24$aBiophysics. 615 24$aPharmacology. 676 $a572.516 676 $a572.3 702 $aZamponi$b Gerald W. 702 $aWeiss$b Norbert 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910624309903321 996 $aVoltage-gated calcium channels$93064947 997 $aUNINA