LEADER 01002nam0-22003611i-450- 001 990001434220403321 010 $a0-387-94934-8 035 $a000143422 035 $aFED01000143422 035 $a(Aleph)000143422FED01 035 $a000143422 100 $a20000920d1998----km-y0itay50------ba 101 0 $aeng 200 1 $aBerkeley problems in mathematics$fPaulo Ney de Souza, Jorge-Numo Silva 210 $aNew York$cSpringer$d1998 215 $axiv, 443 p.$d25 cm 225 1 $aProblem Book in Mathematics 610 0 $aFunzioni di piu variabili 610 0 $aEquazioni differenziali ordinarie 676 $a515.076 700 1$aDe Souza,$bPaulo Ney$061964 702 1$aSilva,$bJorge-Nuno 801 0$aIT$bUNINA$gRICA$2UNIMARC 901 $aBK 912 $a990001434220403321 952 $aC-56-(22$b16248$fMA1 959 $aMA1 962 $a26-06 962 $a26BXX 962 $a34AXX 996 $aBerkeley problems in mathematics$9276229 997 $aUNINA DB $aING01 LEADER 02775nam 2200625Ia 450 001 9910144315303321 005 20170815153142.0 010 $a1-282-13670-4 010 $a9786612136702 010 $a0-470-06677-6 010 $a0-470-06678-4 035 $a(CKB)1000000000376422 035 $a(EBL)470380 035 $a(OCoLC)609849222 035 $a(SSID)ssj0000354570 035 $a(PQKBManifestationID)11249044 035 $a(PQKBTitleCode)TC0000354570 035 $a(PQKBWorkID)10302471 035 $a(PQKB)10407213 035 $a(MiAaPQ)EBC470380 035 $a(EXLCZ)991000000000376422 100 $a19870521d1989 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aOrganic reaction mechanisms$h1987$iAn annual survey covering the literature dated December 1986 to November 1987$b[electronic resource] /$fedited by A.C. Knipe and W.E. Wattts 210 $aLondon ;$aNew York $cInterscience Publishers$d1989 215 $a1 online resource (668 p.) 225 0 $aOrganic reaction mechanicsm ;$v1987 300 $aDescription based upon print version of record. 311 $a0-471-92078-9 320 $aIncludes bibliographical references and index. 327 $aORGANIC REACTION MECHANISMS 1987; Contents; 1. Reactions of Aldehydes and Ketones and their Derivatives; 2. Reactions of Acids and their Derivatives; 3. Radical Reactions: Part 1; 4. Radical Reactions: Part 2; 5. Oxidation and Reduction; 6. Carbenes and Nitrenes; 7. Nucleophilic Aromatic Substitution; 8. Electrophilic Aromatic Substitution; 9. Carbocations; 10. Nucleophilic Aliphatic Substitution; 11. Carbanions and Electrophilic Aliphatic Substitution; 12. Elimination Reactions; 13. Addition Reactions: Polar Addition; 14. Addition Reactions: Cycloaddition; 15. Molecular Rearrangements 327 $aAuthor IndexSubject Index 330 $aThis is the latest volume of an annual review that contains essays published on laboratory developments, including radical and addition reactions and molecular arrangements. It is designed as a reference work for researchers in organic reaction mechanisms and their applications. 410 0$aOrganic Reaction Mechanisms Series 606 $aChemistry, Organic 606 $aOrganic reaction mechanisms 608 $aElectronic books. 615 0$aChemistry, Organic. 615 0$aOrganic reaction mechanisms. 676 $a547.1 676 $a547.139 676 $a547.2 701 $aKnipe$b A. C$0854345 701 $aWatts$b W. E$095643 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910144315303321 996 $aOrganic reaction mechanisms$91910006 997 $aUNINA LEADER 08334nam 2200469 450 001 9910624305003321 005 20231110215700.0 010 $a9783031205149$b(electronic bk.) 010 $z9783031205132 035 $a(MiAaPQ)EBC7130139 035 $a(Au-PeEL)EBL7130139 035 $a(CKB)25264913400041 035 $a(PPN)266349234 035 $a(EXLCZ)9925264913400041 100 $a20230317d2022 uy 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aCell biology and translational medicine$hVolume 17 $estem cells in tissue differentiation, regulation and disease /$fedited by Kursad Turksen 210 1$aCham, Switzerland :$cSpringer,$d[2022] 210 4$d©2022 215 $a1 online resource (249 pages) 225 1 $aAdvances in Experimental Medicine and Biology ;$vv.1401 311 08$aPrint version: Turksen, Kursad Cell Biology and Translational Medicine, Volume 17 Cham : Springer,c2022 9783031205132 320 $aIncludes bibliographical references and index. 327 $aIntro -- Preface -- Contents -- Endothelialization and Inflammatory Reactions After Intracardiac Device Implantation -- 1 Introduction -- 2 Intracardiac Devices -- 2.1 PFO Occluders -- 2.1.1 Amplatzer PFO Occluder -- 2.1.2 Gore Septal Occluder -- 2.1.3 Flex II PFO Occluder -- 2.2 ASD Occluders -- 2.2.1 Amplatzer Septal Occluder -- 2.2.2 Occlutech ASD Occluder -- 2.3 Left Atrial Appendage Occluders -- 2.3.1 Watchman Device -- 2.3.2 Amulet Occluder -- 2.4 Transcatheter Aortic Valve Implantation -- 2.4.1 Edwards SAPIEN 3/SAPIEN 3 Ultra -- 2.4.2 Medtronic Evolut R/Evolut PRO -- 2.5 Leadless Pacemakers -- 3 Common Device Components -- 3.1 Nitinol -- 3.2 Titanium -- 3.3 Tungsten -- 3.4 Gold -- 3.5 Steel -- 4 Cardiac Injury, Wound Healing, and Regeneration - A Brief Overview -- 4.1 Pro-inflammatory Phase -- 4.2 Cell Proliferation Phase -- 4.3 Endothelialization and Resolution of Inflammation -- 5 Discussion -- 6 Conclusion -- 7 Limitations -- References -- Articular Cartilage Regeneration in Veterinary Medicine -- 1 Cartilage and Its (In)Ability to Heal -- 2 Osteoarthritis in Companion Animals -- 3 Pain Management of OA -- 3.1 Conservative Treatment -- 3.2 Novel Pain Management Treatment Options -- 3.2.1 Platelet-Rich Plasma -- 3.2.2 Anti-nerve Growth Factor Monoclonal Antibodies Therapy -- 3.2.3 Mesenchymal Stem Cells/Medicinal Signaling Cells -- 4 Surgical Treatment of OA and Cartilage Defects -- 4.1 Conventional Treatment Options -- 4.2 Reparative Treatment Techniques -- 4.3 Regenerative Treatment Options -- 4.3.1 Osteochondral Transplantation -- 4.3.2 Autologous Chondrocyte Implantation -- 4.3.3 Matrix-Induced ACI (MACI) -- 5 Attempts to Improve Existing Regenerative Treatment Options with the Use of Mesenchymal Stem Cells -- 5.1 Chondrogenic Differentiation of MSCs -- 5.2 Hypertrophy Associated with Chondrogenic Differentiation of MSCs. 327 $a5.3 Attempts at Reduction of MSC Hypertrophy -- 5.3.1 Co-culture -- 5.3.2 PTHrP -- 5.3.3 Matrilin-3 -- 5.3.4 Hypoxia -- 5.4 Biomaterials for Mimicking Native Cartilage Tissue -- 5.4.1 The Influence of the 3D Structure on MSCs -- 5.4.2 Influence of Biomaterial Properties on MSCS -- 5.4.3 General Structure of Biomaterials for Cell Encapsulation -- 5.4.4 Natural Biomaterials to Promote MSC Chondrogenesis -- Collagen -- Hyaluronic Acid -- Silk Fibroin -- Decellularized Cartilage Matrix -- 5.4.5 Role of Mechanical Stimulation in Cartilage Regeneration -- 5.4.6 Importance of Biomaterial Architecture -- 6 Summary -- References -- Adult Stem Cell Therapy as Regenerative Medicine for End-Stage Liver Disease -- 1 End-Stage Liver Disease -- 2 Liver Development and Regeneration -- 3 Stem Cell Therapy -- 3.1 Mesenchymal Stem Cells -- 3.2 Hematopoietic Stem Cells -- 3.3 Endothelial Progenitor Cells -- 3.4 Fetal Human Hepatocytes -- 3.5 Hepatic Lineage Differentiation -- 4 Cell Reprogramming -- 4.1 Induced Pluripotent Stem Cells (iPSC) -- 4.2 Human Liver Organoids (HLO) -- 5 General Perspective -- References -- An Affordable Approach of Mesenchymal Stem Cell Therapy in Treating Perianal Fistula Treatment -- 1 Introduction -- 2 Pathophysiology of Perianal Fistula -- 3 Mechanism of Action of MSCs -- 3.1 Homing Ability -- 3.2 Anti-Inflammatory Mechanism -- 3.3 Cell Proliferation Stage -- 3.4 Re-epithelisation and Tissue Remodelling -- 4 A more Affordable MSC Therapy in Treating PF -- 4.1 Cell Source -- 4.2 Manufacturing Scales -- 4.3 Preconditioning of MSCs -- 4.4 Genetically Modified MSCs -- 4.4.1 Improving Migration -- 4.4.2 Reduced Premature/Replicative Senescence -- 4.4.3 Cost -- 4.5 Cell-Free Therapy -- 5 Remaining Challenges and Conclusion -- References -- Virus, Exosome, and MicroRNA: New Insights into Autophagy -- 1 Autophagy -- 2 MicroRNA and Autophagy. 327 $a2.1 Regulation of Autophagy by MicroRNAs -- 2.2 MiRNAs Interactions in Chemo-Induced Autophagy -- 3 Exosome and Autophagy -- 4 Inhibition or Stimulation of Autophagy by the Virus -- 5 Autophagy Supporting Viral Replication -- 6 Conclusion -- References -- Epitranscriptomics Changes the Play: m6A RNA Modifications in Apoptosis -- 1 Introduction -- 2 Apoptosis -- 3 m6A RNA Modification -- 3.1 Deposition of m6A Modification -- 3.2 Fates of m6A Methylated RNAs -- 4 m6A Modifications in Apoptosis -- References -- The Fingerprints of Biomedical Science in Internal Medicine -- 1 Introduction -- 2 Internal Medicine: Background and Present Status -- 2.1 Common Diagnostic Methods -- 2.2 Common Treatment Options -- 3 Biomedical Science: Subsets and Applications -- 3.1 Cellular and Molecular Biology -- 3.1.1 Biochemistry -- 3.1.2 Genetics -- 3.2 Bioinformatics -- 3.3 Bioengineering -- 3.4 Bionanotechnology -- 3.5 Microbiology -- 3.6 Embryology -- 3.7 Physiology -- 4 Molecular Diagnostics and Multi-Omics Approaches -- 4.1 Molecular Imaging -- 4.2 Single-Cell Multi-Omics Analysis -- 5 Advanced Preclinical Models -- 6 The Next Generation of Treatments -- 6.1 Cell-Based Therapies -- 6.2 Gene-Based Therapies -- 6.3 Regenerative Personalized Medicine -- 7 Conclusion and Future Perspectives -- References -- Mesenchymal Stem Cell-Derived Extracellular Vesicles: Progress and Remaining Hurdles in Developing Regulatory Compliant Qualit... -- 1 Introductions -- 2 Biological Characterization of MSC-EVs -- 2.1 Current Scenario on MSC-EV Characterization Assays -- 3 Quality Control Regulation for MSC-EVs -- 3.1 Establishing QC Assays for EV-Based Products -- 4 Remaining Challenges -- 5 Conclusion -- References -- Pharmacological Effects of Caffeic Acid and Its Derivatives in Cancer: New Targeted Compounds for the Mitochondria -- 1 Background -- 2 Mitochondria in Cancer Cells. 327 $a3 Antineoplastic Agents Targeting Mitochondrial Function -- 4 Polyphenols as Antitumoral Agents -- 5 Caffeic Acid and Its Derivatives with Antitumoral Action -- 6 Mitochondriotropic Derivatives of Caffeic Acid -- 7 Conclusion -- References -- Systematically Assessing Natural Compounds´ Wound Healing Potential with Spheroid and Scratch Assays -- 1 Introduction -- 2 Materials and Methods -- 2.1 Cells and Culture Conditions -- 2.2 Spheroid Formation for Compound Screening -- 2.3 Dissolving Natural Compounds: Spheroid Treatment -- 2.4 Cell Viability and Stains -- 2.5 Scratch Wounds -- 2.6 Imaging and Measurements -- 2.7 Histology -- 2.8 Statistics -- 3 Results -- 3.1 NIH 3T3 Spheroids Self-Assemble from Cell Sheets in the Absence of Extracellular Matrix -- 3.2 Manuka Honey Is a Spheroid-Supporting Compound -- 3.3 Manuka Honey Increases Cell Motility in Scratch Wound Assays -- 4 Discussion -- 4.1 Scaffold-Free Spheroids from NIH 3T3 Cells Form by Substrate-Specific Collective Cellular Processes from Cell Sheets -- 4.2 Using Spheroids and Scratch Wound Healing Assays to Screen Natural Compounds -- 4.3 Usefulness of Our Proposed Workflow -- References -- Index. 410 0$aAdvances in Experimental Medicine and Biology 606 $aRegenerative medicine 615 0$aRegenerative medicine. 676 $a617.51 702 $aTurksen$b Kursad 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 912 $a9910624305003321 996 $aCell biology and translational medicine$92518697 997 $aUNINA