LEADER 04285nam 2201213z- 450 001 9910619465003321 005 20231214133626.0 010 $a3-0365-5324-X 035 $a(CKB)5670000000391624 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/93217 035 $a(EXLCZ)995670000000391624 100 $a20202210d2022 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aState-of-Art in Innate Immunity 210 $cMDPI - Multidisciplinary Digital Publishing Institute$d2022 215 $a1 electronic resource (188 p.) 311 $a3-0365-5323-1 330 $aThe innate immune system is the first line of defense against bacterial and viral infections and sterile inflammation through the recognition of pathogen-associated molecular patterns (PAMPs) by pathogen recognition receptors (PRRs) resulting in the production of proinflammatory and antiviral cytokines and chemokines. Several damage-associated molecular patterns (DAMPs), which were released by passive or active mechanisms under sterile conditions, are additionally recognized by PRRs and can cause or even aggravate the inflammatory response. In this special issue many aspects of innate immunity are summarized. Mechanisms of different DAMPs to induce pro- and anti-inflammatory activities, functions of different immune cells, as well as the crosstalk between coagulation and innate immunity were described. Furthermore, aspects of autoinflammatory diseases, types of programmed cell death pathways, and insect immunity are covered. Finally, therapeutic options for the treatment of diseases related to autoimmunity or infections are suggested. Overall, this special issue presents a broad overview of activities related to sterile inflammation and defense mechanisms of innate immunity. 606 $aMedicine$2bicssc 610 $ainflammation 610 $atype I interferons 610 $ainterleukin-1? 610 $acrosstalk 610 $ahepatic non-parenchymal cells 610 $aalbumin 610 $achronic liver diseases 610 $abacteria 610 $acytomegalovirus 610 $aendothelin receptor 610 $arepurposing 610 $acell culture 610 $aDrosophila suzukii 610 $ahemocytes 610 $aplasmatocytes 610 $aextracellular traps 610 $aHMGB1 610 $aRAGE 610 $aTLR4 610 $aDAMP 610 $aSIRT1 610 $a?7-nicotinic acetylcholine receptor 610 $anociceptor 610 $acancer 610 $aCOVID-19 610 $aproteostasis 610 $aautoinflammation 610 $aribosomopathies 610 $aproteinopathies 610 $aproteasomopathies 610 $aextracellular RNA 610 $acytokines 610 $amacrophages 610 $aendothelial cells 610 $atoll-like receptors 610 $aangiogenesis 610 $a?? T cells 610 $agamma delta T cells 610 $aproliferation 610 $amacrophage polarization 610 $aneutrophils 610 $aneutrophil extracellular traps 610 $aNETs 610 $aischemia 610 $aPANoptosis 610 $aPANoptosome 610 $apyroptosis 610 $aapoptosis 610 $anecroptosis 610 $ainflammatory cell death 610 $ainflammasome 610 $ainnate immunity 610 $ainfection 610 $aNLR 610 $acaspase 610 $aIRF1 610 $aZBP1 610 $aRIPK1 610 $aRIPK3 610 $aMLKL 610 $aNLRP3 610 $aAIM2 610 $aPyrin 610 $acaspase-1 610 $aASC 610 $acaspase-8 610 $acaspase-3 610 $acaspase-7 610 $aplasticity 610 $aredundancy 610 $aSMOC1 610 $athrombin 615 7$aMedicine 700 $aFischer$b Silvia$4edt$01320373 702 $aDeindl$b Elisabeth$4edt 702 $aFischer$b Silvia$4oth 702 $aDeindl$b Elisabeth$4oth 906 $aBOOK 912 $a9910619465003321 996 $aState-of-Art in Innate Immunity$93034203 997 $aUNINA