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010   $a9783031065668$b(electronic bk.)
010   $z9783031065651
024 7 $a10.1007/978-3-031-06566-8
035   $a(MiAaPQ)EBC7113829
035   $a(Au-PeEL)EBL7113829
035   $a(CKB)25161871600041
035   $a(DE-He213)978-3-031-06566-8
035   $a(PPN)265856310
035   $a(EXLCZ)9925161871600041
100   $a20221015d2022      u|         0
101 0 $aeng
135   $aurcnu||||||||
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aPI3K and AKT Isoforms in Immunity $eMechanisms and Therapeutic Opportunities /$fedited by Margarita Dominguez-Villar
205   $a1st ed. 2022.
210  1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2022.
215   $a1 online resource (462 pages)
225 1 $aCurrent Topics in Microbiology and Immunology,$x2196-9965 ;$v436
311 08$aPrint version: Dominguez-Villar, Margarita PI3K and AKT Isoforms in Immunity Cham : Springer International Publishing AG,c2022 9783031065651 
320   $aIncludes bibliographical references.
327   $aClass I PI3K biology -- Class II PI3K biology -- Class III PI3K biology -- PTEN in immunity -- PHLPP Signaling in Immune Cells -- PHLPP Signaling in Immune Cells -- PI3K isoforms in cell signalling and innate immune cell responses -- AKT isoforms in macrophage activation, polarization and survival -- Control of CD4+ T cell Differentiation and Function by PI3K isoforms. -- PI3K isoforms in CD8+ T cell development and function -- PI3K isoforms in B cells -- PI3K isoform signalling in platelets -- PI3K isoforms in vascular biology, a focus on the vascular system-immune response connection -- PI3K and AKT at the Interface of Signaling and Metabolism -- The Role of PI3K Isoforms in Autoimmune Disease -- AKT Isoforms in the Immune Response in Cancer -- PI3K isoform immunotherapy for solid tumours -- PI3K targeting in non-solid cancer -- AKT isoforms as a target in cancer and immunotherapy -- Developing PI3K Inhibitors for Respiratory Diseases.
330   $aThis book provides an essential overview of the role of phosphoinositide-3-phosphate kinase (PI3K) isoforms in modulating the function of immune system cells and their involvement in disease. PI3K is a family of kinases involved in basic cellular processes such as proliferation, migration and cell death. Recent work has highlighted the multiple roles of PI3K classes and subunits and their involvement in the immune response to the body?s own and foreign antigens and diseases such as cancer and autoimmunity. This book offers a detailed introduction to the biology of the three PI3K classes, followed by an extensive discussion of the diverse roles of AKT and PI3K isoforms in immune cells. Based on this knowledge, it subsequently explains in more detail how specific isoforms are connected to immune-mediated diseases. The book concludes by highlighting the latest advances in the production of isoform-specific inhibitors and their use in various human diseases. This book is intended as a reference guide for students and researchers interested in the multifaceted aspects of PI3K biology.
410  0$aCurrent Topics in Microbiology and Immunology,$x2196-9965 ;$v436
606   $aImmunology
606   $aImmune system
606   $aCellular signal transduction
606   $aCytology
606   $aAutoimmunity
606   $aImmunospecificity
606   $aImmunology
606   $aImmune Cell Signalling
606   $aCell Biology
606   $aAutoimmunity
606   $aAdaptive Immunity
606   $aFosfatidilinositols$2thub
606   $aImmunitat cel·lular$2thub
608   $aLlibres electrònics$2thub
615  0$aImmunology.
615  0$aImmune system.
615  0$aCellular signal transduction.
615  0$aCytology.
615  0$aAutoimmunity.
615  0$aImmunospecificity.
615 14$aImmunology.
615 24$aImmune Cell Signalling.
615 24$aCell Biology.
615 24$aAutoimmunity.
615 24$aAdaptive Immunity.
615  7$aFosfatidilinositols
615  7$aImmunitat cel·lular
676   $a616.079
676   $a616.079
702   $aDominguez-Villar$b Margarita
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
912   $a9910617304203321
996   $aPI3K and AKT Isoforms in Immunity$92953619
997   $aUNINA