LEADER 04419nam  22008055  450 
001 9910616399103321
005 20240429094902.0
010   $a9783031045448$b(electronic bk.)
010   $z9783031045431
024 7 $a10.1007/978-3-031-04544-8
035   $a(MiAaPQ)EBC7102203
035   $a(Au-PeEL)EBL7102203
035   $a(CKB)24950458200041
035   $a(DE-He213)978-3-031-04544-8
035   $a(PPN)264955382
035   $a(EXLCZ)9924950458200041
100   $a20220926d2022      u|         0
101 0 $aeng
135   $aurcnu||||||||
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aPeptide Therapeutics $eFundamentals of Design, Development, and Delivery /$fedited by Seetharama D. Jois
205   $a1st ed. 2022.
210  1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2022.
215   $a1 online resource (321 pages)
225 1 $aAAPS Advances in the Pharmaceutical Sciences Series,$x2210-738X ;$v47
311 08$aPrint version: Jois, Seetharama D. Peptide Therapeutics Cham : Springer International Publishing AG,c2022 9783031045431 
320   $aIncludes bibliographical references and index.
327   $aBasic Concepts of Design of Peptide based Therapeutics -- Computational Methods in Peptide Based Drug Design -- Synthesis, Purification, and Characterization of Linear and Cyclic Peptides -- Large Scale Synthesis of Peptides, Manufacturing Peptide Therapeutics -- Stability of Peptides -- Peptide Delivery Systems -- Liposomes and Nanoparticle Formulations for Peptide Delivery -- Delivery of Peptides Across the Blood-brain Barrier (BBB) -- Peptide Therapeutics Regulatory Considerations.
330   $aThis book explains how peptide-based drug design works, what steps are needed to develop a peptide-based therapeutic, and challenges in synthesis as well as regulatory issues. It covers the design concept of peptide therapeutics from fundamental principles using structural biology and computational approaches. The chapters are arranged in a linear fashion. A fresh graduate or a scientist who works on small molecules can use this to follow the design and development of peptide therapeutics to use as understanding the basic concepts. Each chapter is written by experts from academia as well as industry. Rather than covering extensive literature, the book provides concepts of design, synthesis, delivery, as well as regulatory affairs and manufacturing of peptides in a systematic way with examples in each case. The book can be used as a reference for a pharmaceutical or biomedical scientist or graduate student who wants to pursue their career in peptide therapeutics. Some chapters will be written as a combination of basic principles and protocol so that scientists can adopt these methods to their research work. The examples provided can be used to perform peptide formulation considerations for the designed peptides. The book has nine chapters, and each chapter can be read as an independent unit on a particular concept.
410  0$aAAPS Advances in the Pharmaceutical Sciences Series,$x2210-738X ;$v47
606   $aPharmaceutical chemistry
606   $aDrug delivery systems
606   $aDrugs$xDesign
606   $aPharmacology
606   $aPharmacy
606   $aProteins$xSynthesis
606   $aPharmaceutics
606   $aDrug Delivery
606   $aStructure-Based Drug Design
606   $aPharmacology
606   $aPharmacy
606   $aProtein Synthesis and Translation
606   $aMedicaments peptídics$2thub
606   $aQuímica farmacèutica$2thub
608   $aLlibres electrònics$2thub
615  0$aPharmaceutical chemistry.
615  0$aDrug delivery systems.
615  0$aDrugs$xDesign.
615  0$aPharmacology.
615  0$aPharmacy.
615  0$aProteins$xSynthesis.
615 14$aPharmaceutics.
615 24$aDrug Delivery.
615 24$aStructure-Based Drug Design.
615 24$aPharmacology.
615 24$aPharmacy.
615 24$aProtein Synthesis and Translation.
615  7$aMedicaments peptídics
615  7$aQuímica farmacèutica
676   $a615.19
676   $a615.19
702   $aJois$b Seetharama D.
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
912   $a9910616399103321
996   $aPeptide Therapeutics$92929666
997   $aUNINA