LEADER 01004nam0-22003131i-450- 001 990004347950403321 005 20050204141248.0 035 $a000434795 035 $aFED01000434795 035 $a(Aleph)000434795FED01 035 $a000434795 100 $a19990604d1974----km-y0itay50------ba 101 0 $aita 105 $ay-------001yy 200 1 $aCENTO anni di studi su Cavour, testi antologici da C. Cavour$fV. Gioberti ... $g Enzo Tagliacozzo 210 $aMessina , Firenze$cD'Anna$d1974. 215 $a233 p.$d21 cm 225 1 $aSecondo millennio$v20 676 $a945.0834$v21$zita 702 1$aCavour,$bCamillo Benso$c 702 1$aGioberti,$bVincenzo$f<1801-1852> 702 1$aTagliacozzo,$bEnzo 801 0$aIT$bUNINA$gRICA$2UNIMARC 901 $aBK 912 $a990004347950403321 952 $a945.08 TAG 1$bI.st.r.c.2217$fFLFBC 959 $aFLFBC 996 $aCENTO anni di studi su Cavour, testi antologici da C. Cavour$9486011 997 $aUNINA LEADER 00827nam0-22002771i-450- 001 990001055480403321 005 20100519155007.0 035 $a000105548 035 $aFED01000105548 035 $a(Aleph)000105548FED01 035 $a000105548 100 $a20001205d1956----km-y0itay50------ba 101 0 $aeng 200 1 $a<>essays on the foundations of geometry$fby Bertrand Russell$gwith a new foreword by Morris Kline 210 $aNew York$cDover$d1956 610 0 $aStoria della matematica 676 $a509 700 1$aRussell,$bBertrand$f<1872-1970>$07043 702 1$aKline,$bMorris$f<1908-1992> 801 0$aIT$bUNINA$gRICA$2UNIMARC 901 $aBK 912 $a990001055480403321 952 $a6B-060$b927$fFI1 959 $aFI1 996 $aEssays on the foundations of geometry$9340552 997 $aUNINA LEADER 04527nam 22006615 450 001 9910616204803321 005 20251009103227.0 010 $a9783031099366$b(electronic bk.) 010 $z9783031099359 024 7 $a10.1007/978-3-031-09936-6 035 $a(MiAaPQ)EBC7105514 035 $a(Au-PeEL)EBL7105514 035 $a(CKB)24978733400041 035 $a(PPN)265861950 035 $a(DE-He213)978-3-031-09936-6 035 $a(OCoLC)1347019737 035 $a(EXLCZ)9924978733400041 100 $a20221003d2022 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aOpioids $ePharmacology, Abuse, and Addiction /$fedited by Silvia L. Cruz 205 $a1st ed. 2022. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2022. 215 $a1 online resource (390 pages) 225 1 $aBiomedical and Life Sciences Series 311 08$aPrint version: Cruz, Silvia L. Opioids Cham : Springer International Publishing AG,c2022 9783031099359 320 $aIncludes bibliographical references and index. 327 $aPart I. Social aspects of opioid use -- Chapter 1: A brief history of opioids and the evolution of concepts associated with substance use disorders -- Chapter 2: The two sides of opioid use: Unmet needs of opioids for pain management and the role of opioids in substance use disorders -- Chapter 3: Opioid markets and special populations -- Chapter 4: Towards a new drug policy agreement -- Chapter 5: The opioid crises -- Chapter 6: Persons who misuse opioids -- Chapter 7: The need for structural interventions for persons who misuse opioids -- Part II. Pharmacological and medical aspects of opioid use -- Chapter 8: Opioid effects and classification -- Chapter 9: Opioid receptors and neuronal signal transduction -- Chapter 10: Opioids in Pain -- Chapter 11: Opioids in Palliative Care -- Chapter 12: Opioids and the immune system -- Chapter 13: Opioid dependence, tolerance, and withdrawal -- Chapter 14: Medication-Assisted Treatment (MAT) 1: Opioid substitution therapy -- Chapter 15: Medication-Assisted Treatment for Opioid Use Disorders 2. Detoxification -- Chapter 16: Synthetic Opioids as New Psychoactive Substances (NPS). 330 $aOpioids are the mainstay in pain treatment and can be invaluable medications in palliative care. However, they are also responsible for the vast majority of preventable deaths related to drug use. This book presents an overview of the social and pharmacological aspects of opioid effects, aiming to provide researchers and health professionals with a firm understanding of their effects and mechanisms of action. The first section reviews the history of opioids from ancient civilizations to the current opioid crisis, gives voice to opioid users through first-hand testimonies, analyzes the existing international drug treatment agreements, and presents structured interventions for persons who misuse opioids. The second section covers state-of-the-art advances in the medical use of opioids, opioid-induced signal transduction, opioids in pain management, opioid use disorders and their treatment. It also presentsan updated view of opioids as regulators of inflammation and host defense against pathogens and damage. The overall aim of this book is to provide the reader with a deeper knowledge of this field despite the complexities associated with the existence of numerous ligands, receptor subtypes, and complex pharmacological profiles. To this end, the chapter authors are specialists in the field who also have extensive experience in teaching, hoping to lend their expertise in translating complex concepts into comprehensive and clear explanations. 410 0$aBiomedical and Life Sciences Series 606 $aPharmacology 606 $aNeurosciences 606 $aNeurology 606 $aPain medicine 606 $aPharmacology 606 $aNeuroscience 606 $aNeurology 606 $aPain Medicine 615 0$aPharmacology. 615 0$aNeurosciences. 615 0$aNeurology. 615 0$aPain medicine. 615 14$aPharmacology. 615 24$aNeuroscience. 615 24$aNeurology. 615 24$aPain Medicine. 676 $a362.2930974 676 $a615.783 702 $aCruz$b Silvia L. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 912 $a9910616204803321 996 $aOpioids$92940573 997 $aUNINA