LEADER 04594nam 22006855 450 001 9910616204803321 005 20260605212047.0 010 $a9783031099366$b(electronic bk.) 024 7 $a10.1007/978-3-031-09936-6 035 $a(MiAaPQ)EBC7105514 035 $a(Au-PeEL)EBL7105514 035 $a(CKB)24978733400041 035 $a(PPN)265861950 035 $a(DE-He213)978-3-031-09936-6 035 $a(OCoLC)1347019737 035 $a(EXLCZ)9924978733400041 100 $a20221003d2022 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aOpioids $ePharmacology, Abuse, and Addiction /$fedited by Silvia L. Cruz 205 $a1st ed. 2022. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2022. 215 $a1 online resource (390 pages) 225 1 $aBiomedical and Life Sciences Series 311 08$aPrint version: Cruz, Silvia L. Opioids Cham : Springer International Publishing AG,c2022 9783031099359 320 $aIncludes bibliographical references and index. 327 $aPart I. Social aspects of opioid use -- Chapter 1: A brief history of opioids and the evolution of concepts associated with substance use disorders -- Chapter 2: The two sides of opioid use: Unmet needs of opioids for pain management and the role of opioids in substance use disorders -- Chapter 3: Opioid markets and special populations -- Chapter 4: Towards a new drug policy agreement -- Chapter 5: The opioid crises -- Chapter 6: Persons who misuse opioids -- Chapter 7: The need for structural interventions for persons who misuse opioids -- Part II. Pharmacological and medical aspects of opioid use -- Chapter 8: Opioid effects and classification -- Chapter 9: Opioid receptors and neuronal signal transduction -- Chapter 10: Opioids in Pain -- Chapter 11: Opioids in Palliative Care -- Chapter 12: Opioids and the immune system -- Chapter 13: Opioid dependence, tolerance, and withdrawal -- Chapter 14: Medication-Assisted Treatment (MAT) 1: Opioid substitution therapy -- Chapter 15: Medication-Assisted Treatment for Opioid Use Disorders 2. Detoxification -- Chapter 16: Synthetic Opioids as New Psychoactive Substances (NPS). 330 $aOpioids are the mainstay in pain treatment and can be invaluable medications in palliative care. However, they are also responsible for the vast majority of preventable deaths related to drug use. This book presents an overview of the social and pharmacological aspects of opioid effects, aiming to provide researchers and health professionals with a firm understanding of their effects and mechanisms of action. The first section reviews the history of opioids from ancient civilizations to the current opioid crisis, gives voice to opioid users through first-hand testimonies, analyzes the existing international drug treatment agreements, and presents structured interventions for persons who misuse opioids. The second section covers state-of-the-art advances in the medical use of opioids, opioid-induced signal transduction, opioids in pain management, opioid use disorders and their treatment. It also presentsan updated view of opioids as regulators of inflammation and host defense against pathogens and damage. The overall aim of this book is to provide the reader with a deeper knowledge of this field despite the complexities associated with the existence of numerous ligands, receptor subtypes, and complex pharmacological profiles. To this end, the chapter authors are specialists in the field who also have extensive experience in teaching, hoping to lend their expertise in translating complex concepts into comprehensive and clear explanations. 410 0$aBiomedical and Life Sciences Series 606 $aPharmacology 606 $aNeurosciences 606 $aNeurology 606 $aPain medicine 606 $aPharmacology 606 $aNeuroscience 606 $aNeurology 606 $aPain Medicine 606 $aOpiacis$2thub 608 $aLlibres electrònics$2thub 615 0$aPharmacology. 615 0$aNeurosciences. 615 0$aNeurology. 615 0$aPain medicine. 615 14$aPharmacology. 615 24$aNeuroscience. 615 24$aNeurology. 615 24$aPain Medicine. 615 7$aOpiacis 676 $a362.2930974 676 $a615.783 702 $aCruz$b Silvia L. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 912 $a9910616204803321 996 $aOpioids$92940573 997 $aUNINA