LEADER 02857nam  2200361   450 
001 9910598188003321
005 20230224143052.0
035   $a(CKB)3800000000216557
035   $a(NjHacI)993800000000216557
035   $a(EXLCZ)993800000000216557
100   $a20230224d2017      uy             0
101 0 $aeng
135   $aur|||||||||||
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 00$aRecent advances and perspectives in deoxynivalenol research /$fedited by Marc Maresca
210  1$a[Place of publication not identified] :$cMDPI - Multidisciplinary Digital Publishing Institute,$d2017.
215   $a1 online resource (ix, 285 pages) $cillustrations
311   $a3-03842-470-6 
330   $aAnnotation Mycotoxins are secondary metabolites produced by molds. Although the primary role of these toxins is thought to be related to the colonisation of the environment by the fungi--mycotoxins are able to kill other micro-organisms (antimicrobial effect) and/or plant cells (mycotoxin-producing fungi being necrophagic)--the exposure of animals and humans to mycotoxins through the consumption of mycotoxin-contaminated food and feeds leads to diseases and death. Among the different mycotoxins described (more than 350 mycotoxins have been identified), deoxynivalenol (DON or vomitoxin) produced by Fusarium species has attracted the most attention due to its prevalence and toxicity. DON is part of a family of mycotoxins called trichothecenes that are small sesquiterpenoids with an epoxide group at positions 12-13 allowing their binding to ribosomes causing the so-called ribosome stress response, characterized by the activation of various protein kinases that lead to alterations in gene expression and cellular toxicity in animals, humans and plants. Here, we compiled very recent findings regarding DON and its derivatives: i. their prevalence in human food; ii. the estimation of the exposure of humans to them using biological markers; iii. their roles during plant-fungi interaction; iv. the alteration caused by them in animals and humans, particularly at low doses that are close to those observed in farm animals and human consumers; v. possible strategies to decrease their presence in food and feeds. Overall, this book will give the reader a clear and global view on this important mycotoxin produced by Fusarium species which is responsible for huge economic loss and health issues. Dr. Marc Maresca Guest Editor.
606   $aMycotoxins$vCongresses
606   $aMycotoxins
615  0$aMycotoxins
615  0$aMycotoxins.
676   $a615.95292
702   $aMaresca$b Marc
801  0$bNjHacI
801  1$bNjHacl
906   $aBOOK
912   $a9910598188003321
996   $aRecent Advances and Perspectives in Deoxynivalenol Research$92935167
997   $aUNINA