LEADER 00756nam1-22002891i-450- 001 990000006380403321 035 $a000000638 035 $aFED01000000638 035 $a(Aleph)000000638FED01 035 $a000000638 100 $a20011111d--------km-y0itay50------ba 101 0 $aita 105 $ay-------001yy 200 1 $aMacchine a gas$fGiuseppe Dabini. 210 $aFirenze$cSansoni$d1971- 215 $av.$d24 cm 463 \1$1001990000188950503321$12001 $a4. : 473 p. : ill. 610 0 $aMacchine a gas 676 $a621.2 700 1$aDabini,$bGiuseppe$0331071 801 0$aIT$bUNINA$gRICA$2UNIMARC 901 $aBK 912 $a990000006380403321 959 $aFINBC 996 $aMacchine a gas$9107782 997 $aUNINA DB $aING01 LEADER 00742nam0-22002651i-450- 001 990004714110403321 005 19990530 035 $a000471411 035 $aFED01000471411 035 $a(Aleph)000471411FED01 035 $a000471411 100 $a19990530g19849999km-y0itay50------ba 101 0 $aita 105 $ay-------001yy 200 1 $aFortuna e ri-creazione$eTemi classici e letterature moderne$fInnocente Toppani 210 $aBologna$cPitagora$dc1984. 215 $a98 p.$d21 cm 700 1$aToppani,$bInnocente$0187920 801 0$aIT$bUNINA$gRICA$2UNIMARC 901 $aBK 912 $a990004714110403321 952 $aFCL 2564$bBibl.20233$fFLFBC 959 $aFLFBC 996 $aFortuna e ri-creazione$9557410 997 $aUNINA LEADER 01202nam0-22003851i-450- 001 990005498440203316 005 20030716120000.0 035 $a000549844 035 $aUSA01000549844 035 $a(ALEPH)000549844USA01 035 $a000549844 100 $a20010829d2001-------|0enac50------ba 101 $aeng 102 $aUS 105 $a|||| ||||| 200 1 $a<> introduction to hig frequency finance$fMichel M. Dacorogna...[et al.] 210 $aSan Diego [etc.]$cAcademic Press$dc2001 215 $aXXX, 383 p.$cill.$d24 cm 606 $aAnalisi serie temporali$2FI 606 $aFinanza$xmodelli econometrici$2FI 620 $dSan Diego 676 $a332.0151$cEconomia finanziaria - Tecniche matematiche$v21 702 1$aDACOROGNA,$bMichel M. 712 $aAcademic press 801 $aIT$bSOL$c20120104 912 $a990005498440203316 950 $aDIP.TO SCIENZE ECONOMICHE - (SA)$dDS 300 332.0151 DAC$e9744 DISES 951 $a300 332.0151 DAC$b9744 DISES 959 $aBK 969 $aDISES 979 $c20121027$lUSA01$h1532 979 $c20121027$lUSA01$h1613 996 $aIntroduction to hig frequency finance$91129370 997 $aUNISA NUM $aUSA10566 LEADER 02843nam 2200385 450 001 9910598025003321 005 20230217163133.0 035 $a(CKB)4100000011302086 035 $a(NjHacI)994100000011302086 035 $a(EXLCZ)994100000011302086 100 $a20230217d2020 uy 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aIron as Therapeutic Targets in Human Diseases$hVolume 1 /$fPaolo Arosio, Maura Poli, Raffaella Gozzelino, editors 210 1$a[Place of publication not identified] :$cMDPI - Multidisciplinary Digital Publishing Institute,$d2020. 215 $a1 online resource (472 pages) 311 $a3-03928-082-1 330 $aIron is an essential element for almost all organisms, a cofactor playing a crucial role in a number of vital functions, including oxygen transport, DNA synthesis, and respiration. However, its ability to exchange electrons renders excess iron potentially toxic, since it is capable of catalyzing the formation of highly poisonous free radicals. As a consequence, iron homeostasis is tightly controlled by sophisticated mechanisms that have been partially elucidated. Because of its biological importance, numerous disorders have been recently linked to the deregulation of iron homeostasis, which include not only the typical disorders of iron overload and deficiency but also cancer and neurodegenerative diseases. This leads iron metabolism to become an interesting therapeutic target for novel pharmacological treatments against these diseases. Several therapies are currently under development for hematological disorders, while other are being considered for different pathologies. The therapeutic targeting under study includes the hepcidin/ferroportin axis for the regulation of systemic iron homeostasis, complex cytosolic machineries for the regulation of the intracellular iron status and its association with oxidative damage, and reagents exploiting proteins of iron metabolism such as ferritin and transferrin receptor. A promising potential target is a recently described form of programmed cell death named ferroptosis, in which the role of iron is essential but not completely clarified. This Special Issue has the aim to summarize the state-of-the-art, and the latest findings published in the iron field, as well as to elucidate future directions. 606 $aBiochemistry 606 $aBiomolecules 615 0$aBiochemistry. 615 0$aBiomolecules. 676 $a574.192 702 $aArosio$b Paolo 702 $aPoli$b Maura 702 $aGozzelino$b Raffaella 801 0$bNjHacI 801 1$bNjHacl 906 $aBOOK 912 $a9910598025003321 996 $aIron as Therapeutic Targets in Human Diseases$93011763 997 $aUNINA