LEADER 04480nam 2200397 450 001 9910598018003321 005 20230328134203.0 035 $a(CKB)4100000002152769 035 $a(NjHacI)994100000002152769 035 $a(EXLCZ)994100000002152769 100 $a20230328d2018 uy 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aAR Signaling in human malignancies $eprostate cancer and beyond /$fEmmanuel S. Antonarakis, editor 210 1$aBasel :$cMDPI AG - Multidisciplinary Digital Publishing Institute,$d[2018] 210 4$dİ2018 215 $a1 online resource (244 pages) 311 $a3-03842-740-3 327 $aAbout the Special Issue Editor v --Preface to "AR Signaling in Human Malignancies: Prostate Cancer and Beyond" -- Emmanuel S. Antonarakis --AR Signaling in Human Malignancies: Prostate Cancer and Beyond -- Michael T. Schweizer and Evan Y. Yu -- AR-Signaling in Human Malignancies: Prostate Cancer and Beyond -- Megan Crumbaker, Leila Khoja and Anthony M. Joshua -- AR Signaling and the PI3K Pathway in Prostate Cancer -- Daisuke Obinata, Kenichi Takayama, Satoru Takahashi and Satoshi Inoue Crosstalk of the Androgen Receptor with Transcriptional Collaborators: Potential -- Therapeutic Targets for Castration-Resistant Prostate Cancer -- Kurtis Eisermann and Gail Fraizer -- The Androgen Receptor and VEGF: Mechanisms of Androgen-Regulated Angiogenesis in Prostate Cancer -- Damien A. Leach and Grant Buchanan Stromal Androgen Receptor in Prostate Cancer Development and Progression -- Vito Cucchiara, Joy C. Yang, Vincenzo Mirone, Allen C. Gao, Michael G. Rosenfeld and Christopher P. Evans -- Epigenomic Regulation of Androgen Receptor Signaling: Potential Role in Prostate Cancer Therapy -- Hubert Pakula, Dongxi Xiang and Zhe Li A Tale of Two Signals: AR and WNT in Development and Tumorigenesis of Prostate and Mammary Gland -- Bilal Rahim and Ruth ORegan -- AR Signaling in Breast Cancer -- Ramesh Narayanan and James T. Dalton -- Androgen Receptor: A Complex Therapeutic Target for Breast Cancer -- Yuka Asano, Shinichiro Kashiwagi, Wataru Goto, Sayaka Tanaka, Tamami Morisaki, Tsutomu Takashima, Satoru Noda, Naoyoshi Onoda, Masahiko Ohsawa, Kosei Hirakawa and Masaichi Ohira Expression and Clinical Significance of Androgen Receptor in Triple-Negative Breast Cancer -- Peng Li, Jinbo Chen and Hiroshi Miyamoto -- Androgen Receptor Signaling in Bladder Cancer -- Martin G. Dalin, Philip A. Watson, Alan L. Ho and Luc G. T. Morris -- Androgen Receptor Signaling in Salivary Gland Cancer -- Tatsuo Kanda, Koji Takahashi, Masato Nakamura, Shingo Nakamoto, Shuang Wu, Yuki Haga, Reina Sasaki, Xia Jiang and Osamu Yokosuka -- Androgen Receptor Could Be a Potential Therapeutic Target in Patients with Advanced Hepatocellular Carcinoma. 330 $aThe notion that androgens and androgen receptor (AR) signaling are the hallmarks of prostate cancer oncogenesis and disease progression is generally well accepted. What is more poorly understood is the role of AR signaling in other human malignancies. This Special Issue of Cancers initially reviews the role of AR in advanced prostate cancer, and then explores the potential importance of AR signaling in other epithelial malignancies. The first few articles focus on the use of novel AR-targeting therapies in castration-resistant prostate cancer and the mechanisms of resistance to novel antiandrogens, and they also outline the interaction between AR and other cellular pathways, including PI3 kinase signaling, transcriptional regulation, angiogenesis, stromal factors, Wnt signaling, and epigenetic regulation in prostate cancer. The next several articles review the possible role of androgens and AR signaling in breast cancer, bladder cancer, salivary gland cancer, and hepatocellular carcinoma, as well as the potential treatment implications of using antiandrogen therapies in these non-prostatic malignancies. 517 $aAR Signaling in Human Malignancies 606 $aProstate$xCancer 606 $aProstate$xCancer$xAlternative treatment 615 0$aProstate$xCancer. 615 0$aProstate$xCancer$xAlternative treatment. 676 $a616.99463 702 $aAntonarakis$b Emmanuel S. 801 0$bNjHacI 801 1$bNjHacl 906 $aBOOK 912 $a9910598018003321 996 $aAR Signaling in human malignancies$93079618 997 $aUNINA LEADER 02127nam 2200469z- 450 001 9910557528003321 005 20211118 035 $a(CKB)5400000000044298 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/74170 035 $a(oapen)doab74170 035 $a(EXLCZ)995400000000044298 100 $a20202111d2020 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aBiosafety of Genetically Modified Organisms, Volume II 210 $cFrontiers Media SA$d2020 215 $a1 online resource (252 p.) 311 08$a2-88966-033-8 330 $aThis eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! 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