LEADER 02356nam 2200361 450 001 9910597994803321 005 20230221212704.0 035 $a(CKB)4920000001372202 035 $a(NjHacI)994920000001372202 035 $a(EXLCZ)994920000001372202 100 $a20230221d2017 uy 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aRecent advances in HTLV research 2015 /$fedited by Louis M Mansky 210 1$aBasel, Switzerland :$cMDPI - Multidisciplinary Digital Publishing Institute,$d[2017] 210 4$dİ2017 215 $a1 online resource (viii, 300 pages) $cillustrations 311 $a3-03842-376-9 320 $aIncludes bibliographical references. 330 $aThe human T-cell leukemia virus types 1 and 2 (HTLV-1 and HTLV-2) were both discovered over three decades ago and infect millions people worldwide. HTLV-1 is associated with the adult T-cell leukemia/lymphoma (ATLL) in about 2% of individuals infected, and another 2 to 3% of individuals develop a neurologic disorder called HTLV-associated myelopathy (HAM). HTLV-2 causes HAM in approximately 1 to 2% of infected individuals, but does not cause ATLL. HTLV-1 and HTLV-2 have served as excellent models for the study of the epidemiology and pathogenesis of virus-associated cancers as well as autoimmune conditions such as multiple sclerosis. Recently, two new members--HTLV-3 and HTLV-4--have been discovered in bushmeat hunters from central Africa, which emphasizes the urgent need for continual surveillance for new human retroviruses and their capacity to cause disease. Important public health issues remain open issues to be addressed in spite of the basic epidemiology of HTLV-1 and HTLV-2 being reasonably well defined. Clinical research is needed in developing potential HTLV-1 and HTLV-2 vaccines, as well as development of treatment options for ATLL and HAM. This 'Recent Advances Issue' contains both reviews and updates on research that encompasses these areas. 606 $aHTLV (Viruses) 615 0$aHTLV (Viruses) 676 $a616.994071 702 $aMansky$b Louis M. 801 0$bNjHacI 801 1$bNjHacl 906 $aBOOK 912 $a9910597994803321 996 $aRecent Advances in HTLV Research 2015$92936268 997 $aUNINA