LEADER 02467nam 2200361 450 001 9910597956203321 005 20230218122742.0 035 $a(CKB)4920000001372518 035 $a(NjHacI)994920000001372518 035 $a(EXLCZ)994920000001372518 100 $a20230218d2018 uy 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aTransient Receptor Potential (TRP) Channels in Drug Discovery $eOld Concepts & New Thoughts /$fSusan M. Huang, Arpad Szallasi 210 1$aBasel :$cMDPI - Multidisciplinary Digital Publishing Institute,$d2018. 215 $a1 online resource (vi, 250 pages) 311 $a3-03842-639-3 330 $aThe year 2017 marks the 20th anniversary of the molecular cloning of the long sought-after capsaicin receptor, now known as TRPV1 (Transient Receptor Potential Vanilloid 1). This seminal discovery has opened up a "hot" new field of basic research and launched drug discovery efforts into the large family (by the latest count, 28 mammalian members and 27 in humans) of TRP ion channels. Indeed, it took less than a decade for the first potent, small molecule TRPV1 antagonists to enter phase 1 clinical trials, closely followed by TRPA1 and TRPM8 antagonists. The literature on TRP channels is immense. TRPV1 alone is a keyword in over 5000 publications searchable in PubMed. Clearly, it is not possible to capture the entire literature in a single thematic issue. Consequently, the selection of articles presented in this book represents a sampling of the literature, and is admittedly subjective. We tried to survey the wide range of human diseases in which TRP channels have been implicated, ranging from chronic pain through asthma and diabetes to cancer, and highlight the channels that appear to hold the greatest promise for therapeutic targeting. With this book, we hope to convince readers that TRP channels constitute a formidable family of potential therapeutic targets that will likely continue to demand attention. 517 $aTransient Receptor Potential 606 $aTRP channels 615 0$aTRP channels. 676 $a572.696 700 $aHuang$b Susan M.$01278323 702 $aSzallasi$b Arpad 801 0$bNjHacI 801 1$bNjHacl 906 $aBOOK 912 $a9910597956203321 996 $aTransient Receptor Potential (TRP) Channels in Drug Discovery$93013095 997 $aUNINA