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071 50$a3818$bHenry Stewart Talks
100   $a20141027d2014      ||         v
101 0 $aeng
135   $aurcna|||a||||
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aMismatch repair deficient cancers diagnosis, treatment and prevention /$fJohn Burn
210   $aLondon $cHenry Stewart Talks$d2014
215   $a1 online resource (1 streaming video file (44 min.) $ccolor, sound)
225 1 $aMolecular genetics of human disease,$x2056-452X
300   $aAnimated audio-visual presentation with synchronized narration.
300   $aTitle from title frames.
327   $aContents: Lynch syndrome (underlying single gene defect) -- Microsatellites -- Important genes containing repeat sequences -- MSI testing (5 marker panel) -- Mismatch repair (MMR) -- The genomic pathogenesis of colorectal cancer (CRC) -- EGFR and BRAF mutant inhibition -- BRAF colon cancer project -- Methotrexate & MMR deficient tumours -- Africans & bowel cancer (Dennis Burkitt) -- Cancer prevention program (CaPP) -- NSAIDs and reduced colorectal cancer risk -- Aspirin effect on polyps in FAP and colorectal adenoma -- The prevention paradox -- CaPP2 (Colorectal & Lynch syndrome cancers) -- Meta-analysis of cancer deaths with aspirin treatment -- CRCs in people on aspirin (mostly COX2 negative) -- Individual response to aspirin in cancer prevention -- History of salicylate as an essential nutrient -- CaPP3 study -- Peptides created by slippage in microsatellite coding -- Antibodies as a possible biomarker for Lynch syndrome -- The Micoryx vaccine.
410  0$aHenry Stewart talks.$pBiomedical & life sciences collection.$pMolecular genetics of human disease.
606   $aAspirin
606   $aCancer$xGenetic aspects
606   $aColon (Anatomy)$xCancer$xGenetic aspects
606   $aColon (Anatomy)$xCancer$xTreatment
606   $aMedical genetics
606   $aMolecular genetics
606   $aRectum$xCancer$xGenetic aspects
606   $aRectum$xCancer$xTreatment
606   $aAspirin$xtherapeutic use
606   $aBiomarkers
606   $aColorectal Neoplasms$xdiagnosis
606   $aColorectal Neoplasms$xgenetics
606   $aColorectal Neoplasms$xtherapy
606   $aColorectal Neoplasms, Hereditary Nonpolyposis
606   $aDNA Mismatch Repair
606   $aGenetics, Medical
606   $aMicrosatellite Instability
606   $aMicrosatellite Repeats
615  0$aAspirin.
615  0$aCancer$xGenetic aspects.
615  0$aColon (Anatomy)$xCancer$xGenetic aspects.
615  0$aColon (Anatomy)$xCancer$xTreatment.
615  0$aMedical genetics.
615  0$aMolecular genetics.
615  0$aRectum$xCancer$xGenetic aspects.
615  0$aRectum$xCancer$xTreatment.
615  2$aAspirin$xtherapeutic use.
615  2$aBiomarkers.
615  2$aColorectal Neoplasms$xdiagnosis.
615  2$aColorectal Neoplasms$xgenetics.
615  2$aColorectal Neoplasms$xtherapy.
615  2$aColorectal Neoplasms, Hereditary Nonpolyposis.
615  2$aDNA Mismatch Repair.
615  2$aGenetics, Medical.
615  2$aMicrosatellite Instability.
615  2$aMicrosatellite Repeats.
700   $aBurn$b John$cMD, MRCP.$4spk$01739013
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996   $aMismatch repair deficient cancers diagnosis, treatment and prevention$94162530
997   $aUNINA