LEADER 03992nam 2201033z- 450 001 9910595079403321 005 20231214133201.0 035 $a(CKB)5680000000080731 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/92076 035 $a(EXLCZ)995680000000080731 100 $a20202209d2022 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aEnhancing Mesenchymal Stem Cells (MSCs) for Therapeutic Purposes 210 $aBasel$cMDPI Books$d2022 215 $a1 electronic resource (204 p.) 311 $a3-0365-4996-X 311 $a3-0365-4995-1 330 $aThe regenerative and immunomodulatory properties of mesenchymal stem cells (MSCs) have made these cells the focus of multiple pre-clinical studies and clinical trials. While the results from these clinical studies have established that MSCs are safe, the efficacy of these cells is not as well-established. In this regard, there have been increased efforts towards generating potentiated/activated MSCs with enhanced therapeutic efficacy. Research on the mechanisms for enhancing MSC potency and efficacy is an area of active study with great potential for translation into clinical settings. The purpose of this book is to bring together recent research from a broad range of topics relating to potentiation strategies for enhancing MSC therapeutic efficacy, including growth factor pre-conditioning, hypoxia, and 3D culture. The research compiled in this book increases the basic understanding of MSC culture techniques and describes some MSC preparations for potential novel therapeutic applications. 517 $aEnhancing Mesenchymal Stem Cells 606 $aMedicine$2bicssc 610 $acell therapy 610 $aimmunomodulation 610 $apolyunsaturated fatty acid 610 $aCD206 610 $aphagocytosis 610 $amesenchymal stem cells 610 $aVadadustat 610 $aAKB-6548 610 $apreconditioning 610 $apriming 610 $asecretome 610 $achemotaxis 610 $aWharton?s jelly mesenchymal stem cells 610 $aumbilical cord 610 $aoxygen conditions 610 $asecretory profile 610 $aneuroprotection 610 $amesenchymal stromal cells 610 $a3D culture 610 $aneurospheres 610 $aspheroids 610 $apluripotency 610 $aneural 610 $aquiescence 610 $amesothelioma 610 $amalignant pleural mesothelioma (MPM) 610 $aliver cirrhosis 610 $aplacenta-derived mesenchymal stem cells 610 $aWKYMVm 610 $acombination therapy 610 $aiPSC-derived MSCs 610 $aiMSC secretome 610 $apre-conditioning 610 $aangiogenesis 610 $aIFN-? 610 $ahypoxia 610 $apotentiation of iMSC efficacy 610 $ananofiber-hydrogel composite 610 $aspinal cord injury 610 $ainflammation 610 $amacrophages 610 $asecondary injury 610 $aastrocytes 610 $aaxon growth 610 $aadipose tissue-derived stem cells (ASCs) 610 $aautophagy 610 $arapamycin 610 $a3-methyladenine 610 $aimmunosuppression 610 $aexosome 610 $aengineered cardiac patches 610 $aadipose-derived stem cell 610 $aparacrine potential 610 $aosteogenic differentiation 610 $ahepatocyte growth factor 610 $afibroblast growth factor 2 615 7$aMedicine 700 $aYlostalo$b Joni H$4edt$01289237 702 $aDurand$b Nisha C$4edt 702 $aYlostalo$b Joni H$4oth 702 $aDurand$b Nisha C$4oth 906 $aBOOK 912 $a9910595079403321 996 $aEnhancing Mesenchymal Stem Cells (MSCs) for Therapeutic Purposes$93030230 997 $aUNINA