LEADER 05130nam 2201237z- 450 001 9910595078103321 005 20220916 035 $a(CKB)5680000000080745 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/92020 035 $a(oapen)doab92020 035 $a(EXLCZ)995680000000080745 100 $a20202209d2022 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aPrecision Medicine in Solid Tumors 210 $aBasel$d2022 215 $a1 online resource (304 p.) 311 08$a3-0365-4791-6 311 08$a3-0365-4792-4 330 $aIn the era of precision medicine, the use of molecularly targeted therapies in selected patients has led to a paradigm change in cancer treatment. Multiple studies have demonstrated the benefits of therapies that are chosen based on the molecular profile of the tumor and also from the liquid biopsy. With genomics' increasing ability, a routine transcriptomics analysis of advanced/metastatic cancers is now feasible in most cancer hospitals, including community cancer centers. This is an unprecedented shift in the management of cancers irrespective of their organ types, which not only improved the outcome but also opened several new avenues in research and practice, such as immune-check-point inhibitors, tumor-TME co-evolution in the development of resistance, longitudinal liquid biopsies, biomarkers screening and the management of electronic medical records.This book brings together these crucial areas of investigation. The research presented here attempts to address the current issues to provoke thoughts for the future. The future of precision medicine will have to embrace a shift from in vitro, in vivo/PDX models for the mechanistic study to a more functional test based on the scientific interrogation of genomic data, in the form of functional precision medicine. We will also have to combat the element of noise in the multitudes of data and impart the regulatory structure to make judicious use of the data. The expectations for functional precision medicine are high. We aspire to witness a tremendous improvement in patient outcomes, from better to best, down the road that will match the clinical guidelines. 606 $aMedicine and Nursing$2bicssc 606 $aOncology$2bicssc 610 $aadjuvant chemotherapy 610 $aanaplastic lymphoma receptor tyrosine kinase 610 $abreast cancer 610 $acancer 610 $acancer-associated fibroblasts 610 $acfDNA 610 $achemotherapy 610 $acirculating free DNA 610 $aclinical guideline 610 $aclonality classification 610 $acomprehensive genomic profiling 610 $aCTC 610 $actDNA 610 $aDDR genes 610 $aDecision tree 610 $adigital enrichment 610 $adriver mutation 610 $aEGFR mutation 610 $aEGFR-TKI 610 $aelectronic records 610 $aepidermal growth factor receptor 610 $aextent of resection 610 $agene panel sequencing 610 $aglioblastoma prognosis 610 $aHNSCC 610 $aimmune checkpoint inhibitors 610 $aimmunocytochemistry 610 $aimmunotherapy 610 $aintratumor heterogeneity 610 $alaboratory-friendly 610 $aliquid biopsy 610 $amolecular barcoding 610 $amolecular genotyping 610 $amultiple biopsies 610 $an/a 610 $anew drug development 610 $anext-generation sequencing 610 $anext-generation sequencing (NGS) 610 $aNGS 610 $anon-small cell lung cancer 610 $aopen data 610 $aosimertinib 610 $aoutcome 610 $aoverall survival 610 $aparallel double-detection 610 $aPARP inhibitors 610 $aPD-L1 610 $apediatric tumors 610 $apersonalized precision oncology 610 $aprecision medicine 610 $apresumed germline findings 610 $arandom forest 610 $aregulatory reform 610 $aresistance 610 $ascreening 610 $asequencing 610 $asmoking 610 $asolid cancer 610 $astrategic therapeutic intervention 610 $atargeted therapy 610 $atDNA 610 $athymoma 610 $aTMB 610 $aTNBC subtypes 610 $atriple-negative breast cancer (TNBC) 610 $atumor evolution 610 $atumor mutational burden 610 $atumor profiling test 610 $atyrosine kinase inhibitor 610 $auniversal health-care system 610 $awhole-exome sequencing 615 7$aMedicine and Nursing 615 7$aOncology 700 $aDey$b Nandini$4edt$01332329 702 $aDe$b Pradip$4edt 702 $aDey$b Nandini$4oth 702 $aDe$b Pradip$4oth 906 $aBOOK 912 $a9910595078103321 996 $aPrecision Medicine in Solid Tumors$93040843 997 $aUNINA