LEADER 05235nam 22007335 450 001 9910595061703321 005 20240415115011.0 010 $a3-031-08415-2 024 7 $a10.1007/978-3-031-08415-7 035 $a(MiAaPQ)EBC7098175 035 $a(Au-PeEL)EBL7098175 035 $a(CKB)24866050500041 035 $a(DE-He213)978-3-031-08415-7 035 $a(PPN)264955315 035 $a(EXLCZ)9924866050500041 100 $a20220920d2022 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aMessenger RNA Therapeutics /$fedited by Stefan Jurga, Jan Barciszewski 205 $a1st ed. 2022. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2022. 215 $a1 online resource (451 pages) 225 1 $aRNA Technologies,$x2197-9758 ;$v13 311 08$aPrint version: Jurga, Stefan Messenger RNA Therapeutics Cham : Springer International Publishing AG,c2022 9783031084140 327 $aThe Democratization of RNA Therapeutics -- Supramolecular Strategies for mRNA Delivery -- In Vitro-Transcribed mRNAs as a New Generation of Therapeutics in the Dawn of 21st Century: Exploitation of Peptides as Carriers for their Intracellular Delivery -- Effective Delivery of mRNA Therapeutics and Vaccines Using Lipid Nanoparticles -- Messenger RNA Therapeutics -- Formulation, Delivery and Application of mRNA Therapeutics In Respiratory Diseases -- Clinical Applications of mRNA Formulated In Lipid Nanoparticles -- Preparation of Messenger RNA Loaded Nanomedicine Applied on Tissue Engineering And Regenerative Medicine -- Lipid Nanoparticle-Mediated Delivery of mRNA Therapeutics: Immune Activation By Ionizable Cationic Lipids -- Adjuvants, the Elephant in the Room for RNA Vaccines -- Addressing Skin with Modified mRNA Constructs for Novel Therapies -- mRNA-Based Cancer Immunotherapies -- From Bench to Bedside: The Journey of an mRNA Drug Candidate Into a Medicine -- Synthetic mRNA Gene Therapies for Chronic HBV Infection -- Delivery Vehicles for Self-Amplifying RNA -- Delivery Technologies of mRNA Vaccines -- Nanosystems: The Key in Formulations of mRNA for Several Pathologies -- Messenger RNA Nanoformulation For Cancer Vaccine -- Preparation of Synthetic mRNAs for In Vivo Applications ? Overview and Considerations -- Messenger RNA for Prophylaxis -- Nuclear Export of mRNA with Disease Pathogenesis and Therapeutic Potentials -- Messenger RNA Therapeutics: Start of a New Era in Medicine -- mRNA Delivery Technologies for Therapeutic Applications. 330 $aThis book focuses on the fundamentals and applications of messenger RNA (mRNA)-based therapeutics and discusses the strengths and key challenges of this emerging class of drugs. In the past 30 years, extensive research and technological development in many areas have contributed to the emergence of in vitro transcribed mRNA as a therapeutic that has now reached clinical testing. Formulations that protect the mRNA from nucleases and accelerate its cellular uptake, combined with improvements to the mRNA molecules themselves, have been critical advancements for mRNAs to become viable therapeutics. Though once regarded as a serious impediment, the transient nature of mRNA technology is now considered a major advantage in making mRNA therapies safe and, ultimately, a potential game changer in the field of medicine. This new book in the RNA Technologies series provides a state-of-the-art overview on the emerging field of mRNA therapeutics covering essential strategies for formulation, delivery, and application. It also reviews the promising role in cancer immunotherapy, respiratory diseases, and chronic HBV infection and discusses RNA vaccines in light of the current COVID-19 pandemic. mRNA-based approaches have great potential to revolutionize molecular biology, cell biology, biomedical research, and medicine. Thus, this handbook is an essential resource for researchers in academia and industry contributing to the development of this new area of therapeutics. 410 0$aRNA Technologies,$x2197-9758 ;$v13 606 $aMedical genetics 606 $aMedicinal chemistry 606 $aNanomedicine 606 $aCancer$xTreatment 606 $aMedical Genetics 606 $aMedicinal Chemistry 606 $aNanomedicine and Nanotoxicology 606 $aCancer Therapy 606 $aQuimioteràpia$2thub 606 $aVacunes$2thub 606 $aRNA$2thub 608 $aLlibres electrònics$2thub 615 0$aMedical genetics. 615 0$aMedicinal chemistry. 615 0$aNanomedicine. 615 0$aCancer$xTreatment. 615 14$aMedical Genetics. 615 24$aMedicinal Chemistry. 615 24$aNanomedicine and Nanotoxicology. 615 24$aCancer Therapy. 615 7$aQuimioteràpia 615 7$aVacunes 615 7$aRNA 676 $a615.58 676 $a615.58 700 $aJurga$b Stefan$01258028 702 $aBarciszewski$b Jan 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910595061703321 996 $aMessenger RNA Therapeutics$92915679 997 $aUNINA