LEADER 01104nam0-2200301---450- 001 990009432400403321 005 20120202144718.0 035 $a000943240 035 $aFED01000943240 035 $a(Aleph)000943240FED01 035 $a000943240 100 $a20110926d1961----km-y0itay50------ba 101 0 $aita 102 $aIT 105 $aa-------001yy 200 1 $a<>igiene della macellazione nel quadro della moderna organizzazione dei mattatoi pubblici$erelazione al 15. convegno della Societa italiana delle scienze veterinarie$eGardone, 28 settembre-1 ottobre 1961$fM. Asdrubali, R. Coppini 210 $aFaenza$cF.lli Lega$d1961 215 $a195 p.$cill.$d25 cm 300 $aIn front.: gli autori hanno potuto correggere una sola volta le bozze 700 1$aAsdrubali,$bMario$0343190 701 1$aCoppini,$bRemo$071162 801 0$aIT$bUNINA$gRICA$2UNIMARC 901 $aBK 912 $a990009432400403321 952 $a52 F 20$fDMVAP 959 $aDMVAP 996 $aIgiene della macellazione nel quadro della moderna organizzazione dei mattatoi pubblici$9759680 997 $aUNINA LEADER 06680nam 22007335 450 001 9910595057103321 005 20251009094102.0 010 $a3-031-11836-7 024 7 $a10.1007/978-3-031-11836-4 035 $a(MiAaPQ)EBC7087989 035 $a(Au-PeEL)EBL7087989 035 $a(CKB)24837137700041 035 $a(DE-He213)978-3-031-11836-4 035 $a(PPN)264953770 035 $a(EXLCZ)9924837137700041 100 $a20220915d2022 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aNuclear Receptors in Human Health and Disease /$fedited by Moray J. Campbell, Charlotte L. Bevan 205 $a1st ed. 2022. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2022. 215 $a1 online resource (338 pages) 225 1 $aAdvances in Experimental Medicine and Biology,$x2214-8019 ;$v1390 311 08$aPrint version: Campbell, Moray J. Nuclear Receptors in Human Health and Disease Cham : Springer International Publishing AG,c2022 9783031118357 320 $aIncludes bibliographical references and index. 327 $aIntroduction (Moray J Campbell & Charlotte L Bevan) -- Overview (Jason Carroll) -- Part I: Reproduction and Development -- Chapter 1. Nuclear receptors in pregnancy and outcomes: clinical perspective (Luiza Borges Manna & Catherine Williamson) -- Chapter 2. Female Reproductive Systems: hormone dependence and receptor expression (Philippa TK Saunders) -- Chapter 3. Nuclear receptors in ovarian function (Darryl Russell & Doan Thao Dinh) -- Part II: Metabolism -- Chapter 4. Nuclear receptors in energy metabolism (Alina Walth, Stephan Herzig & Maria Rohm) -- Chapter 5. Nuclear Receptors and lipid sensing (James L Thorne and Giorgia Cioccoloni) -- Part III: Central Systems -- Chapter 6. Corticosteroid receptors in Cardiac health and disease (Jessica Ivy, Gillian Gray, Megan Holmes, Martin Denvir, Karen Chapman) -- Chapter 7. Physiological convergence and antagonism between GR and PPAR? in inflammation and metabolism (Marija Dacic, Gayathri Shibu and Inez Rogatsky) -- Chapter 8. Circadian Rhythm and Nuclear Receptors (David W Ray) -- Chapter 9. Vitamin D and gut health (James C Fleet) -- Part IV: Cancer -- Chapter 10. Estrogen Receptor alpha and ESR1 Mutations in Breast Cancer (Jaymin Patel & Rinath Jeselsohn) -- Chapter 11. AR structural variants and prostate cancer (Laura Cato) -- Chapter 12. ER? and inflammation (Linnea Hases, Amena Archer & Cecilia Williams) -- Chapter 13. Genomic insights into non-steroidal nuclear receptors in prostate and breast cancer (Sajad A Wani & Moray Campbell) -- Part V: New developments in transcriptional control by nuclear receptors -- Chapter 14. Protein condensation in the nuclear receptor family; implications for transcriptional output (Monique Appelman, Elle Hollaar, Jurian Schuijers & Saskia WC van Mil) -- Chapter 15. Prostate cancer epigenetic plasticity and enhancer heterogeneity: molecular causes, consequences and clinical implications (Jeroen Kneppers, Andries M Bergman & Wilbert Zwart) -- Chapter 16. Epigenetic coregulation of androgen receptor signaling (Rayzel Fernandes, Damien A. Leach & Charlotte Bevan) -- Part VI: Clinical Translation -- Chapter 17. Cllnical Translation: Targeting the Estrogen Receptor (Jennifer O. Lauchle & Ciara Metcalfe) -- Chapter 18. Drugging the undruggable: targeting the N-terminal domain of nuclear hormone receptors (Marianne Sadar) -- Chapter 19. Genetic Variation and Mendelian Randomization approaches (Mojgan Yazdanpanah, Nahid Yazdanpanah & Despoina Manousaki) -- Index. 330 $aThis book addresses and dissects the roles and crosstalk mechanisms for the 48 human nuclear receptors (NR) in human health and disease. After a State-of-the-Art introduction by an undisputed and celebrated field leader to provide an overview of the field and its significance, chapters are organized into six sections. The first three sections discuss NR roles in Reproduction & Development, Metabolism and Central Systems. These present to the reader our current understanding of NR signaling in the development and functioning of the reproductive system; the roles in the regulation of energy metabolism; and how NR signaling is more widely integrated into systemic functions from calcium flux to circadian rhythm. The subsequent three sections dissect how aberrant NR functions drive Cancer; how new insights into Genomic Interaction are helping to reveal how NR disruption drives disease; and finally, how Translational Efforts are exploiting this understanding from developing novel NR ligands to establishing how underlying genetic variation impacts NR function. Within these sections the chapters also illustrate emerging understanding of how the epigenome and non-coding genome combine to regulate NR function and impact dysfunction. Increasingly these insights cross-fertilize over cell and disease boundaries and it is unsurprising that NR are being explored in novel and new arenas such as the context of neurological disorders and depression. Thus, there is wide scope for re-purposing of licensed drugs and development of new NR-targeting therapies for a host of conditions and diseases. This unique book brings together many of the leading figures in NR research from across the globe, to discuss emerging roles and their implications for human health and disease. It summarizes the state of the art and shows signposts for future research to further shape this influential field. 410 0$aAdvances in Experimental Medicine and Biology,$x2214-8019 ;$v1390 606 $aMedicine$xResearch 606 $aBiology$xResearch 606 $aMolecular biology 606 $aMetabolism 606 $aGenetics 606 $aCytology 606 $aBiomedical Research 606 $aMolecular Biology 606 $aMetabolism 606 $aGenetics and Genomics 606 $aCell Biology 615 0$aMedicine$xResearch. 615 0$aBiology$xResearch. 615 0$aMolecular biology. 615 0$aMetabolism. 615 0$aGenetics. 615 0$aCytology. 615 14$aBiomedical Research. 615 24$aMolecular Biology. 615 24$aMetabolism. 615 24$aGenetics and Genomics. 615 24$aCell Biology. 676 $a572.8845 676 $a616.07 702 $aBevan$b Charlotte L. 702 $aCampbell$b Moray J. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910595057103321 996 $aNuclear Receptors in Human Health and Disease$92915826 997 $aUNINA