LEADER 04982oam 2200517 450 001 9910820381203321 005 20170523091546.0 010 $a0-12-394818-5 035 $a(OCoLC)859160284 035 $a(MiFhGG)GVRL6ZZV 035 $a(EXLCZ)992550000001108763 100 $a20140227d2014 uy 0 101 0 $aeng 135 $aurun|---uuuua 181 $ctxt 182 $cc 183 $acr 200 10$aAntibody Fc $elinking adaptive and innate immunity /$fMargaret E. Ackerman, Falk Nimmerjahn 210 $aLondon $cAcademic Press$dc2014 210 1$aLondon :$cAcademic Press, an imprint of Elsevier,$d2014. 215 $a1 online resource (xii, 363 pages) $cillustrations (some color) 225 0 $aGale eBooks 300 $aDescription based upon print version of record. 311 $a0-12-394802-9 311 $a1-299-77598-5 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aFront Cover; Antibody Fc: Linking Adaptive and Innate Immunity; Copyright Page; Contents; List of Contributors; 1. EFFECTOR MECHANISMS; 1 Antibody-Dependent Cellular Cytotoxicity (ADCC); Brief History of ADCC; Effector Cells; Receptors Involved; Mechanisms of ADCC; Recognition of the Target Cell and Cross-Linking of the Fc Receptor on the Effector Cell; Downstream Signals in the Effector Cell; Mechanisms of Killing; The Perforin/Granzyme Cell Death Pathway; The FAS-L Pathway; The ROS/ROI Pathway; ADCC Assays in Relation to Killing Mechanisms; ADCC in Monoclonal Antibody Therapy of Cancer 327 $aVersatility of Monoclonal Antibodies as Platforms for Cancer TherapyEvidence for ADCC in Cancer Therapy; ADCC in Infectious Disease: A Correlate of Protection?; Studies of Herpes Simplex Virus; Studies of Human and Simian Immunodeficiency Virus; Ongoing Debate and a Possible Consensus; Rational Modification of ADCC Activity; Enhancing the Link between ADCC and Adaptive Immunity; Perspectives: Future Directions; Acknowledgments; References; 2 Antibody-Dependent Cellular Phagocytosis and Its Impact on Pathogen Control; Introduction; Phagocytic Cells and Their Fc? Receptors 327 $aVarious Receptors for IgGDifferential Expression of Fc? Receptors on Phagocytic Cells; Fc? Receptor-Mediated Phagocytosis by Phagocytes; Signaling by Activating Fc?Rs; Regulation of FcR Signals; Phagosome Maturation; Role of Fc?R-Mediated Phagocytosis for Pathogen Uptake, Cellular Localization, and Pathogen Control; Bacteria; Avoiding Uptake into Phagocytes; Establishing an Intracellular Niche; Evasion Strategy of Bacteria: Proteolytic Degradation of Antibodies; Viruses; Targeting of Viruses to FcRs; Antibody-Dependent Enhancement of Infection; FcR-Mediated Uptake of Parasites and Fungi 327 $aLeishmania-Specific Antibodies Can Shift the Balance between Th1 and Th2 ResponsesToxoplasma is Targeted to Lysosomes in the Presence of Specific Antibody; Antibody-Mediated Phagocytosis of Invasive Fungi; Concluding Remarks; References; 3 Interactions Between the Complement System and Fc? Receptors; Preliminary Comments; Complement Fragment C3b Mediates Binding of IgG Immune Complexes to Primate Erythrocytes: Immune Adherence; Historical Perspective; Modern Times and Mechanisms: CR1 is Removed from Erythrocytes 327 $aComplement Fragment C3d Mediates Binding of Substrates to CR2 on B Cells: Antigen Trafficking and Its Significance in HIV D...Similarities and Differences between CR1 and CR2; The Shuttle Mechanism: CR2 and Antigen Presentation; CR1, CR2, and AIDS; A Clue to a Mechanism: Lessons Learned from Dendritic Cells; Cooperation/Synergy between Fc? Receptors and Complement Receptors on Effector Cells; In Vivo Studies of the Clearance of Opsonized Erythrocytes; In Vitro Evidence for Synergy between Fc? Receptors and Complement Receptors; Interaction between Fc?RIII and CR3; C3b-IgG as a Superopsonin 327 $aInteraction between Fc?R and Complement: Cancer Models 330 $a Antibody Fc is the first single text to synthesize the literature on the mechanisms underlying the dramatic variability of antibodies to influence the immune response. The book demonstrates the importance of the Fc domain, including protective mechanisms, effector cell types, genetic data, and variability in Fc domain function. This volume is a critical single-source reference for researchers in vaccine discovery, immunologists, microbiologists, oncologists and protein engineers as well as graduate students in immunology and vaccinology. Antibodies represent the correlate of p 606 $aImmunoglobulins 606 $aAntibody diversity 615 0$aImmunoglobulins. 615 0$aAntibody diversity. 676 $a616.07/93 700 $aAckerman$b Margaret E$01716022 702 $aNimmerjahn$b Falk 801 0$bMiFhGG 801 1$bMiFhGG 906 $aBOOK 912 $a9910820381203321 996 $aAntibody Fc$94111099 997 $aUNINA LEADER 05183nam 22006975 450 001 9910595044803321 005 20240313122913.0 010 $a9783030968182$b(electronic bk.) 010 $z9783030968175 024 7 $a10.1007/978-3-030-96818-2 035 $a(MiAaPQ)EBC7088029 035 $a(Au-PeEL)EBL7088029 035 $a(CKB)24837136000041 035 $a(DE-He213)978-3-030-96818-2 035 $a(EXLCZ)9924837136000041 100 $a20220915d2022 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aIndexing 'Chav' on Social Media $eTransmodal Performances of Working-Class Subcultures /$fby Emilia Di Martino 205 $a1st ed. 2022. 210 1$aCham :$cSpringer International Publishing :$cImprint: Palgrave Macmillan,$d2022. 215 $a1 online resource (380 pages) 311 08$aPrint version: Di Martino, Emilia Indexing 'Chav' on Social Media Cham : Springer International Publishing AG,c2022 9783030968175 327 $aChapter 1. Introduction -- Chapter 2. Theoretical Framework -- Chapter 3. 'Chav' -- Chapter 4. The Chav -- Chapter 5. New Digital Media and the Chav -- Chapter 6. Pulling the Threads Together and Expanding on 'Chav' in Social Media -- Chapter 7. Concluding Remarks. 330 $a"This marvelous book offers a fresh perspective on class formations in the 21st century. Originally a derogatory epithet for a British underclass, the term Chav was to become the moniker for a gradiently inhabitable social identity, performable and negotiable through the behaviors that make Chav personae identifiable, and eventually to undergo ever-changing forms of reanalysis and regrouping in the lives of British citizens. By carefully tracing these developments through the last two decades, this book shows that any attempt to reify class formations-by criteria of disposable income, and the like-fails utterly to account for the manner in which class identities are created and transformed through the discursive interactions in which they live." -Asif Agha, University of Pennsylvania, USA The book sets out to examine the concept of 'chav', providing a review of its origins, its characterological figures, the process of enregisterment whereby it has come to be recognized in public discourse, and the traits associated with it in traditional media representations. The author then discusses the 'chav' label in light of recent re-appropriations in social network activity (particularly through the video-sharing app TikTok) and subsequent commentary in the public sphere. She traces the evolution of the term from its use during the first decade of the twenty-first century to make sense of class, status and cultural capital, to its resurgence and the ways in which it is still associated with appearance in gendered and classed ways. She then draws on recent developments in linguistic anthropology and embodied sociocultural linguistics to argue that social media users draw on communicative resources to perform identities that are both situated in specific contexts of discourse and dynamically changing, challenging the idea that geo-sociocultural varieties and mannerisms are the sole way of indexing membership of a community. This volume contends that equating 'chav' with 'underclass' in the most recent uses of the concept on social networks may not be the whole story, and the book will be of interest to sociocultural linguistics and identity researchers, as well as readers in anthropology, sociology, British studies, cultural studies, identity studies, digital humanities, and sociolinguistics. Emilia Di Martino is an associate professor at the Suor Orsola Benincasa University of Naples, Italy. She is interested in a wide variety of topics, mostly focusing on the nexus between identity, language, and power. She has presented at many local and international conferences, and has published extensively, including the book Celebrity Accents and Public Identity Construction: Analyzing Geordie Stylizations (2019). 606 $aSociolinguistics 606 $aEthnology 606 $aDigital humanities 606 $aPopular culture 606 $aSocial media 606 $aAnthropological linguistics 606 $aSociolinguistics 606 $aSociocultural Anthropology 606 $aDigital Humanities 606 $aPopular Culture 606 $aSocial Media 606 $aLinguistic Anthropology 615 0$aSociolinguistics. 615 0$aEthnology. 615 0$aDigital humanities. 615 0$aPopular culture. 615 0$aSocial media. 615 0$aAnthropological linguistics. 615 14$aSociolinguistics. 615 24$aSociocultural Anthropology. 615 24$aDigital Humanities. 615 24$aPopular Culture. 615 24$aSocial Media. 615 24$aLinguistic Anthropology. 676 $a306.440941 676 $a306.44 700 $aDi Martino$b Emilia$0326343 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 912 $a9910595044803321 996 $aIndexing 'Chav' on Social Media$92916018 997 $aUNINA