LEADER 04928nam 22007095 450 001 9910590089403321 005 20240408140301.0 010 $a981-19-2960-2 024 7 $a10.1007/978-981-19-2960-1 035 $a(MiAaPQ)EBC7078105 035 $a(Au-PeEL)EBL7078105 035 $a(CKB)24748091300041 035 $a(DE-He213)978-981-19-2960-1 035 $a(PPN)264196686 035 $a(EXLCZ)9924748091300041 100 $a20220827d2022 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aLymphocyte Immunization Therapy (LIT) in Reproductive Failures$b[electronic resource] $eNew Horizons /$fby Mohan Raut, Mugdha Raut 205 $a1st ed. 2022. 210 1$aSingapore :$cSpringer Nature Singapore :$cImprint: Springer,$d2022. 215 $a1 online resource (150 pages) 311 08$aPrint version: Raut, Mohan Lymphocyte Immunization Therapy (LIT) in Reproductive Failures Singapore : Springer,c2022 9789811929595 320 $aIncludes bibliographical references. 327 $aPart I -- Chapter 1: Introduction -- Chapter 2: Recurrent Pregnancy Loss and Recurrent Implantation Failure -- Chapter 3: Immune System -- Chapter 4: Immunology of Pregnancy (Reproductive Immunology) -- Chapter 5: Diagnosis of Alloimmune factor -- Part II -- Chapter 6: Introduction -- Chapter 7: History of LIT -- Chapter 8: Mechanism of Action of LIT -- Chapter 9: Procedure of LIT -- Chapter 10: Safety of LIT -- Chapter 11: Controversies about LIT ? REMIS Study -- Chapter 12: Cochrane Reviews & LIT -- Chapter 13: Recent Meta-analyses & LIT -- Chapter 14: Review of International studies of LIT -- Chapter 15: Case Studies -- Chapter 16: Future of LIT. 330 $aRecurrent Miscarriages (RM) & Implantation Failure (IF) have remained an enigma to clinicians and researchers. Even after ruling out all possible causative factors, 50-60% cases still remain ?Unexplained?. A majority of these so called ?Unexplained? cases are now found to have immunological basis. This book is going into the Immunological aspects of these clinical dilemmas, demystifying the role of Immunology and Immunotherapy in RM and IF. The authors have been working in the field of Reproductive Immunology and Immunotherapy for the last 25 years and they have come out with this book combining the international studies with their own experience. The purpose of writing this book is to provide a comprehensive treatise about Immunotherapy, so that it can become an acceptable modality of treatment in cases where it is needed and is effective. The book discusses the basics in Reproductive Immunology. The immunological changes occurring during pregnancy, the role of Cell mediated Immunity (T cells), Humoral Immunity including cytokines is explained. The normal immunological mechanisms protecting the embryo are highlighted and how these mechanisms are disturbed leading to RM and IF, is also explained. The first and the most discussed method of Immunotherapy is Lymphocyte Immunization Therapy (LIT). The book has given a complete overview of LIT, describing how it created euphoria when it was first introduced, how it gradually went into disrepute and how it is now making a comeback. As the authors have personal experience of LIT, the book gives a detailed and complete information about this active form of immunotherapy. The book has a special section on case studies where the authors have given some clinical case reports (including some of their own), who were treated for immunological factor in RM/IF and were treated with Immunotherapy. These cases can be a useful guide to the readers. The book will be useful not only for undergraduate and postgraduate students but also for clinicians in their practice and for researchers for review of developments in the field. 606 $aImmunology 606 $aMedicine$xResearch 606 $aBiology$xResearch 606 $aGynecology 606 $aHuman physiology 606 $aImmunology 606 $aBiomedical Research 606 $aGynecology 606 $aHuman Physiology 606 $aGinecologia$2thub 606 $aImmunologia$2thub 608 $aLlibres electrònics$2thub 615 0$aImmunology. 615 0$aMedicine$xResearch. 615 0$aBiology$xResearch. 615 0$aGynecology. 615 0$aHuman physiology. 615 14$aImmunology. 615 24$aBiomedical Research. 615 24$aGynecology. 615 24$aHuman Physiology. 615 7$aGinecologia. 615 7$aImmunologia 676 $a174.25 700 $aRaut$b Mohan$01254420 702 $aRaut$b Mugdha 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910590089403321 996 $aLymphocyte Immunization Therapy (LIT) in Reproductive Failures$92908446 997 $aUNINA