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010   $a9783031054600$b(electronic bk.)
010   $z9783031054594
024 7 $a10.1007/978-3-031-05460-0
035   $a(MiAaPQ)EBC7078092
035   $a(Au-PeEL)EBL7078092
035   $a(CKB)24748086700041
035   $a(PPN)264191757
035   $a(DE-He213)978-3-031-05460-0
035   $a(OCoLC)1344015308
035   $a(EXLCZ)9924748086700041
100   $a20220827d2022      u|         0
101 0 $aeng
135   $aurcnu||||||||
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aUnderstanding PTMs in Neurodegenerative Diseases /$fedited by Victor Corasolla Carregari
205   $a1st ed. 2022.
210  1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2022.
215   $a1 online resource (150 pages)
225 1 $aProteomics, Metabolomics, Interactomics and Systems Biology,$x2730-6224 ;$v1382
311 08$aPrint version: Corasolla Carregari, Victor Understanding PTMs in Neurodegenerative Diseases Cham : Springer International Publishing AG,c2022 9783031054594 
320   $aIncludes bibliographical references and index.
327   $aProtein extraction and sample preparation methods for shotgun proteomics with central nervous system cells and brain tissue -- Phosphopeptide enrichment techniques: a pivotal step for phosphoproteomic studies -- Post-Translational Modifications during Brain Development -- Aberrant protein glycosylation in brain cancers, with emphasis on glioblastoma -- Post-Translational Modification in Muscular Dystrophies -- Post-translational Modifications in Parkinson?s Disease -- Histone Modifications in Neurological Disorders -- Mitochondrial dysregulation and the influence in neurodegenerative diseases -- PTMs: A missing piece for schizophrenia studies -- Post-Translational Modifications in Brain Diseases: A Future for Biomarkers -- Index.
330   $aThis new volume, a part of the Proteomics, Metabolomics, Interactomics and Systems Biology series, will explain how proteomic studies of post-translational modifications (PTMs) can be applied to neurodegenerative diseases and relevant studies. The goal of the book is to increase awareness among researchers about how PTMs may be helpful in understanding mechanisms in various neurodegenerative diseases through proteomic studies. This book will serve as a tool for those who want to begin work in the proteomics field and explore how to implement PTMs studies into their work. Chapter authors will describe different PTMs enrichment methods developed by experts in the field so that researchers may learn to apply these methods and techniques to new studies. Divided into three sections, chapters will cover sample preparation, data quality, enrichment techniques, guidelines on how to analyze PTMs, and explain the role of PTMs and different brain diseases. Among those topics includes will be brain cancer, SLA disease, Parkinsons disease, muscular dystrophies, and schizophrenia. This volume will be useful for researchers and students studying brain and neurodegenerative diseases who are interested in delving into work with proteomic studies and PTMs. .
410  0$aProteomics, Metabolomics, Interactomics and Systems Biology,$x2730-6224 ;$v1382
606   $aPost-translational modification
606   $aBioinformatics
606   $aMolecular biology
606   $aNervous system$xDiseases
606   $aPost-translational Modifications
606   $aComputational and Systems Biology
606   $aMolecular Biology
606   $aNeurological Disorders
615  0$aPost-translational modification.
615  0$aBioinformatics.
615  0$aMolecular biology.
615  0$aNervous system$xDiseases.
615 14$aPost-translational Modifications.
615 24$aComputational and Systems Biology.
615 24$aMolecular Biology.
615 24$aNeurological Disorders.
676   $a612.39
676   $a616.80471
702   $aCarregari$b Victor Corasolla
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
912   $a9910590080403321
996   $aUnderstanding PTMs in Neurodegenerative Diseases$94385845
997   $aUNINA