LEADER 05900nam 22007575 450 001 9910585974703321 005 20240228111458.0 010 $a981-16-9232-7 024 7 $a10.1007/978-981-16-9232-1 035 $a(MiAaPQ)EBC7054681 035 $a(Au-PeEL)EBL7054681 035 $a(CKB)24294155000041 035 $a(DE-He213)978-981-16-9232-1 035 $a(PPN)263901467 035 $a(EXLCZ)9924294155000041 100 $a20220728d2022 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aBiomedical Translational Research $eDrug Design and Discovery /$fedited by R.C. Sobti, Naranjan S. Dhalla 205 $a1st ed. 2022. 210 1$aSingapore :$cSpringer Nature Singapore :$cImprint: Springer,$d2022. 215 $a1 online resource (597 pages) 311 08$aPrint version: Sobti, R. C. Biomedical Translational Research Singapore : Springer,c2022 9789811692314 320 $aIncludes bibliographical references and index. 327 $aChapter 1. Emerging Technologies : Gateway to Understand Molecular Insight of Diseases, Newer Drugs, Their Design and Targeting -- Chapter 2. Polypharmacology: New Paradigms in Drug Development -- Chapter 3. Drug Repurposing in Biomedical Research : Benefits and Challenges -- Chapter 4. Computational Methods for Drug Repurposing -- Chapter 5. Genomic Approaches for Drug Repositioning -- Chapter 6. Organ-On-A- Chip: Novel in-Vitro Model For Drug Discovery -- Chapter 7. Precision Radiomolecular Oncology: Challenging the Classical Statistical Evidence Based Medicine -- Chapter 8. Drug Repositioning of the Phenylpiperazine Derivative Naftopidil in Prostate Cancer Treatment -- Chapter 9. Biomarker Based Drug Discovery and Reverse Translational Approach -- Chapter 10. Nanotechnology in Dentistry -- Chapter 11. Nanoparticles a Potential Breakthrough in Counteracting Multidrug-Resistant Bacterial Infections: A Holistic View on Underlying Mechanisms and Antibacterial Properties -- Chapter 12. Emerging Role of Cannabinoid System Modulators in Treatment of Cancer -- Chapter 13. Nanodrugs : A Futuristic Approach for Treating Nephrolithiasis -- Chapter 14. Lipo Dermaceuticals : Technological Transformation -- Chapter 15. The Importance of Drug Dose Adjustment in Elderly Patients with Special Considerations for Patients on Diverse Co-Medications and Antidepressants -- Chapter 16. Role of Microfluidics and Nano Fluidics in Managing CAD -- Chapter 17. Targeted Gene Delivery Through Magnetofection: The New Face of Medicine -- Chapter 18. Qbd-Steered Systematic Development of Drug Delivery Nanoconstructs : Vital Precepts, Retrospect and Prospects -- Chapter 19. Nanoemulsions: A Potential Advanced Nanocarrier Platform for Herbal Drug Delivery -- Chapter 20. Sirna Encapsulated Nanoparticles for Targeting Dorsal Root Ganglion (Drg) in Diabetic Neuropathic Pain -- Chapter 21. EGFR Targeted Quinazoline Clubbed Heterocycles as Anti-Cancer Agents. Chapter 22. Therapeutic Human Monoclonal Antibodies -- Chapter 23. Hydroxyapatites and Their Biomedical Applications -- Chapter 24. Recent Progress in Applications of Magnetic Nanoparticles in Medicine: A Review -- Chapter 25. Chimeric Antigen Receptor T-Cell Therapy: A Cutting Edge Therapy for Multiple Myeloma -- Chapter 26. Nanoparticles-Associated Lipopeptides: A New Class of Antimicrobials -- Chapter 27. Antimicrobial Applications of Engineered Metal-Based Nanomaterials -- Chapter 28. Strengthening Immunity-Ayurveda & Medicinal Plants -- Chapter 29. The Pathophysiology of Liver Disorders and Pharmacotherapy Options with Special Reference to Traditional Herbal Medicines: A Comprehensive Review -- Chapter 30. Polymeric Vehicles for Controlled Delivery of Ayurvedic Drugs for Wound Management. 330 $aThis book, which is the third volume of Biomedical translational research, focuses on the fundamental role of biomedical research in developing new medicinal products. It emphasizes the importance of understanding biological and pathophysiological mechanisms underlying the disease to discover and develop new biological agents. The book uniquely explores the genomic computational integrative approach for drug repositioning. Further, it discusses the health benefits of nutraceuticals and their application in human diseases. Further, the book comprehensively reviews different computational approaches that employ GWAS data to guide drug repositioning. Finally, it summarizes the major challenges in drug development and the strategies for the rational design of the next generation more effective but less toxic therapeutic agents. 606 $aMedicine$xResearch 606 $aBiology$xResearch 606 $aDrugs$xDesign 606 $aPharmaceutical chemistry 606 $aGenomics 606 $aBioinformatics 606 $aBiomedical Research 606 $aStructure-Based Drug Design 606 $aPharmaceutics 606 $aGenomics 606 $aBioinformatics 606 $aDisseny de medicaments$2thub 606 $aEnginyeria biomèdica$2thub 608 $aLlibres electrònics$2thub 615 0$aMedicine$xResearch. 615 0$aBiology$xResearch. 615 0$aDrugs$xDesign. 615 0$aPharmaceutical chemistry. 615 0$aGenomics. 615 0$aBioinformatics. 615 14$aBiomedical Research. 615 24$aStructure-Based Drug Design. 615 24$aPharmaceutics. 615 24$aGenomics. 615 24$aBioinformatics. 615 7$aDisseny de medicaments 615 7$aEnginyeria biomèdica 676 $a610.28 702 $aSobti$b R. C. 702 $aDhalla$b Naranjan S. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910585974703321 996 $aBiomedical translational research$93363998 997 $aUNINA