LEADER 05076nam 2201477z- 450 001 9910585945403321 005 20220812 035 $a(CKB)5600000000483023 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/91234 035 $a(oapen)doab91234 035 $a(EXLCZ)995600000000483023 100 $a20202208d2022 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aTheme Issue Honoring Prof. Dr. Ludger Wessjohann?s 60th Birthday: Natural Products in Modern Drug Discovery 210 $aBasel$cMDPI - Multidisciplinary Digital Publishing Institute$d2022 215 $a1 online resource (360 p.) 311 08$a3-0365-4744-4 311 08$a3-0365-4743-6 330 $aNature continuously produces biologically useful molecules and provides humankind with life-saving drugs or therapies. Natural products (NPs) offer a vast, unique and fascinating chemical diversity and these molecules have evolved for optimal interactions with biological macromolecules. Moreover, natural products feature pharmacologically active pharmacophores which are pharmaceutically validated starting points for the development of new lead compounds. Over half of all approved (from 1981 to 2014) small-molecule drugs derived from NPs, including unaltered NPs, NPs synthetic derivatives and synthetic natural mimics, originated from a NPs pharmacophore or template. According to the FDA, NPs and their derivatives represent over one-third of all FDA-approved new drugs, in particular for anticancer/antibiotic lead compounds, which are remarkably enriched with NPs. 517 $aTheme Issue Honoring Prof. Dr. Ludger Wessjohann?s 60th Birthday 606 $aChemistry$2bicssc 606 $aOrganic chemistry$2bicssc 606 $aResearch and information: general$2bicssc 610 $aampullosporin 610 $aangiogenesis 610 $aanti-tumor peptides 610 $aantibody engineering 610 $aanticancer 610 $aanticancer activity 610 $aantifungal 610 $aantiproliferative 610 $aapoptosis 610 $aapoptosis resistance 610 $aATG 4B 610 $abiorthogonal chemistry 610 $abispecific antibody 610 $abotanical agents 610 $abreast cancer 610 $abutein 610 $acancer stem cells 610 $acancer treatment 610 $acaspase-3 610 $aclick chemistry 610 $aco-culture 610 $acoronavirus 610 $aCosmospora sp. 610 $aCOX inhibitory 610 $acytotoxic 610 $acytotoxic activity 610 $aDARTS 610 $aDecachaeta incompta 610 $ademissidine 610 $adocking 610 $adrug resistance 610 $aECD-TDDFT 610 $aelectron paramagnetic resonance (EPR) spectroscopy 610 $aflavonoids 610 $afrondoside-A 610 $afusidic acid 610 $aglutamic acid methyl ester 610 $ahepatocellular carcinoma 610 $ain vitro model 610 $aincomptine A 610 $ainvasion 610 $aiTRAQ 610 $akaempferol 610 $alung cancer 610 $aMagnaporthe oryzae 610 $amarine fungi 610 $amedicinal herbs 610 $amelanoma 610 $aMERS-CoV 610 $ametabolomics 610 $ametastasis 610 $amolecular docking 610 $amolecular networking 610 $amulti-component reaction 610 $an/a 610 $anatural products 610 $aophiobolin A 610 $aPCD 610 $apeptaibols 610 $aphytochemicals 610 $aphytopathogen 610 $apolygodial 610 $apregnancy 610 $aproliferation 610 $aRCE-4 610 $aROS production 610 $aSARS-CoV 610 $aSARS-CoV-2 610 $aSepedonium ampullosporum 610 $asesquiterpene lactone 610 $asolanidane alkaloids 610 $asolanidine 610 $asolid-phase peptide synthesis 610 $asoudanone 610 $aSparticola junci 610 $aSrc 610 $aSTAT3 610 $astemness 610 $asteroidal alkaloids 610 $astructure elucidation 610 $atarget identification 610 $aTEMPO-conjugate 610 $athe Bcl-2-Beclin 1 complex 610 $aTrypsiligase 610 $atumor growth 610 $atumor heterogeneity 610 $atumor microenvironment (TME) 610 $aviability 610 $aviolacein 610 $aWittig reaction 615 7$aChemistry 615 7$aOrganic chemistry 615 7$aResearch and information: general 700 $aHussain$b Hidayat$4edt$01302227 702 $aHussain$b Hidayat$4oth 906 $aBOOK 912 $a9910585945403321 996 $aTheme Issue Honoring Prof. Dr. Ludger Wessjohann?s 60th Birthday: Natural Products in Modern Drug Discovery$93026273 997 $aUNINA