LEADER 05105nam 22007215 450 001 9910584484403321 005 20240415154237.0 010 $a9789811913792$b(electronic bk.) 010 $z9789811913785 024 7 $a10.1007/978-981-19-1379-2 035 $a(MiAaPQ)EBC7042558 035 $a(Au-PeEL)EBL7042558 035 $a(CKB)24242559400041 035 $a(DE-He213)978-981-19-1379-2 035 $a(PPN)263902072 035 $a(EXLCZ)9924242559400041 100 $a20220711d2022 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aMicrofluidics and Multi Organs on Chip /$fedited by P. V. Mohanan 205 $a1st ed. 2022. 210 1$aSingapore :$cSpringer Nature Singapore :$cImprint: Springer,$d2022. 215 $a1 online resource (712 pages) 311 0 $aPrint version: Mohanan, P. V. Microfluidics and Multi Organs on Chip Singapore : Springer,c2022 9789811913785g 320 $aIncludes bibliographical references. 327 $aChapter 1. A Historical and Technological Background to Organs-on-a-Chip -- Chapter 2. Applications of microfluidics -- Chapter 3. Microfluidics based Organ-on-a-chip for cell biology studies -- Chapter 4. Microfluidics in Chemical biology -- Chapter 5. Role of microfluidics in drug delivery -- Chapter 6. Microfluidics in drug discovery -- Chapter 7. Microfludic based sensors -- Chapter 8. Background and Organs-on-a-Chip -- Chapter 9. Culture and co-culture of cells for multi organ on chip -- Chapter 10.Cells and organs on a chip in biomedical sciences -- Chapter 11. Futuristic aspects of organ on a chip -- Chapter 12. Development of Human on a chip -- Chapter 13. Multi-organ on a chip for personalized medicine -- Chapter 14. Development and application of Microfluids in organoid formation -- Chapter 15. Liver on a chip -- Chapter 16. Placenta on Chip: A Modern approach to probe feto-maternal interface -- Chapter 17. Microfluidic retina-on-chip -- Chapter 18. Heart on a chip -- Chapter 19. Kidney on a chip -- Chapter 20. Lungs on a chip -- Chapter 21. Brain on a chip -- Chapter 22. Skin on a chip -- Chapter 23. Organs-on-a-chip in preclinical studies -- Chapter 24. Application of organ on chip in blood brain barrier model -- Chapter 25. Multi organs on a chip in disease modeling -- Chapter 26. Prospects of Medical device on a chip -- Chapter 27. Lab on a chip for precision Medicine -- Chapter 28. Tumour-on-a-chip : Perfusion systems to model the extracellular breast tumour microenvironment:from tumour progression to metastasis formation -- Chapter 29. Building Human In Vitro 3D Models to Replace Animal Studies: During Drug Discovery Research: Scientific, Ethical and Regulatory Considerations. 330 $aThis book highlights the application of microfluidics in cell biology research, chemical biology, and drug discovery. It covers the recent breakthroughs and prospects of organ-on-a-chip, human-on-a-chip, multi-organ-on-a-chip for personalized medicine. The book presents the preclinical studies of organs-on-a-chip, concepts of multiple vascularized organ-on-chips, application of organ-on-a-chip in blood-brain barrier model, culture and co-culture of cells on multi-organ-on-chip and parameter measurements in microfluidic devices. It underscores the advantage of microfluidic devices for developing efficient drug carrier particles, cell-free protein synthesis systems, and rapid techniques for direct drug screening. Further, it entails human-on-a-chip for measuring the systemic response as well as immediate effects of an organ reaction on other organs. In summary, this book reviews the development of a microfluidic-based organ-on-a-chip device for the preclinical evaluation, ADME studies of drugs, chemicals, and medical devices. This book is a valuable source for pharma companies, product developers, students, researchers, academicians, and practitioners. 606 $aMedicine?Research 606 $aBiology?Research 606 $aBiomedical engineering 606 $aToxicology 606 $aCytology 606 $aBiomedical Research 606 $aBiomedical Devices and Instrumentation 606 $aToxicology 606 $aCell Biology 606 $aMicrofluídica$2thub 606 $aEnginyeria biomèdica$2thub 606 $aÒrgans artificials$2thub 608 $aLlibres electrònics$2thub 615 0$aMedicine?Research. 615 0$aBiology?Research. 615 0$aBiomedical engineering. 615 0$aToxicology. 615 0$aCytology. 615 14$aBiomedical Research. 615 24$aBiomedical Devices and Instrumentation. 615 24$aToxicology. 615 24$aCell Biology. 615 7$aMicrofluídica 615 7$aEnginyeria biomèdica 615 7$aÒrgans artificials 676 $a617.95 702 $aMo?hanan$b Pi. Vi 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 912 $a9910584484403321 996 $aMicrofluidics and Multi Organs on Chip$92901415 997 $aUNINA