LEADER 01378nam--2200373---450- 001 990001866360203316 005 20090407125654.0 010 $a950-738-124-4 035 $a000186636 035 $aUSA01000186636 035 $a(ALEPH)000186636USA01 035 $a000186636 100 $a20040721d2004----km-y0itaa50------ba 101 $aspa 102 $aES 105 $ay|||z|||001yy 200 1 $a<> proceso de formulación de la politica comercial Nivel uno de un juego de dos niveles$eestudios de países en el hemisferio occidentale$fBanco Interamericano de Desarollo, Munk centre for international studies University of Toronto, Inter-American dialogue 210 $aBuenos aires$cIntal-ITD-STA$d2004 215 $a91 p.$d28 cm 225 2 $aDocumento de divulgación$v13 410 0$aDocumento de divulgación$v13 606 0 $aAmerica$xPolitica economica 676 $a338.973 700 1$aROSE,$bFrancis$0564561 801 0$aIT$bsalbc$gISBD 912 $a990001866360203316 951 $a338.973 ROS 1 (IEP VIII)$b36190 G.$cIEO VIII$d00086044 959 $aBK 969 $aeco 979 $aACQUISTI$b10$c20040721$lUSA01$h1407 979 $aCHIARA$b90$c20041217$lUSA01$h1148 979 $aRSIAV2$b90$c20090407$lUSA01$h1256 996 $aProceso de formulación de la politica comercial Nivel uno de un juego de dos niveles$9956543 997 $aUNISA LEADER 02483nam 2200409 450 001 9910583500103321 005 20180911110645.0 010 $a0-08-102355-3 010 $a1-78548-265-3 035 $a(CKB)4100000002037915 035 $a(MiAaPQ)EBC5245949 035 $a(PPN)233899650 035 $a(EXLCZ)994100000002037915 100 $a20180220h20182018 uy 0 101 0 $aeng 135 $aurcnu|||||||| 181 $2rdacontent 182 $2rdamedia 183 $2rdacarrier 200 10$aLong non-coding RNA $ethe dark side of the genome /$fAntonin Morillon 210 1$aLondon, [England] ;$aOxford, England :$cISTE Press :$cElsevier,$d2018. 210 4$d©2018 215 $a1 online resource (173 pages) 320 $aIncludes bibliographical references and index. 327 $aForeword -- Preface -- Non-coding RNA, its history and discovery timeline -- Definition and families of long non-coding RNA -- Biological functions of long non-coding RNA -- Non-coding RNA in development -- Long non-coding RNA and cancer -- Concluding perspectives. 330 $a"The dark side of the genome represents vast domains of the genome that are not encoding for proteins--the basic bricks of cellular structure and metabolism. Up to 98% of the human genome is non-coding and produces so-called long non-coding RNA. Some of these non-coding RNA play fundamental roles in cellular identity, cell development and cancer progression. They are now widely studied in many organisms to understand their function. Here, we review this expanding field of research and present the broad functional diversities of those molecules and their putative fundamental and therapeutic roles. We develop the recent history of non-coding RNA, their very much debated classification and how they raise a formidable interest for developmental and tumorigenesis biology. Using classical examples and an extensive bibliography, we illustrate the most studied and attractive examples of these long non-coding RNA, how they interface with epigenetics, genome integrity and expression and what are the current models of their regulatory mechanisms."--Page 4 of cover. 606 $aNon-coding RNA$vLaboratory manuals 615 0$aNon-coding RNA 676 $a572.88 700 $aMorillon$b Antonin$0988949 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910583500103321 996 $aLong non-coding RNA$92261525 997 $aUNINA