LEADER 05432nam 2200601 450 001 9910583473403321 005 20240125100544.0 010 $a0-12-800589-0 010 $a0-12-800188-7 035 $a(CKB)3710000000418681 035 $a(EBL)2060798 035 $a(SSID)ssj0001535869 035 $a(PQKBManifestationID)11841010 035 $a(PQKBTitleCode)TC0001535869 035 $a(PQKBWorkID)11502454 035 $a(PQKB)10992383 035 $a(MiAaPQ)EBC2060798 035 $a(PPN)192176064 035 $a(EXLCZ)993710000000418681 100 $a20150619h20152015 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 14$aThe comprehensive sourcebook of bacterial protein toxins /$fJoseph Alouf, Institut Pasteur, Paris, France, Daniel Ladant, Institut Pasteur, Unite? de Biochimie des Interactions Mole?culaires, Paris, France, Michel R. Popoff, Institut Pasteur, Unite? des Bacte?ries anae?robies et Toxines, Paris, France ; contributors, Klaus Aktories [and one hundred ten others] 205 $a4th ed. 210 1$aAmsterdam, Netherlands :$cElsevier,$d2015. 210 4$dİ2015 215 $a1 online resource (1201 p.) 300 $aDescription based upon print version of record. 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aFront Cover; The Comprehensive Sourcebook of Bacterial Protein Toxins; Copyright Page; Contents; List of Contributors; Introduction to the Fourth Edition; In memory of J. E. Alouf (1929-2014); I. Basic Genomic and Physiological Aspects of Bacterial Protein Toxins; 1 Evolutionary aspects of toxin-producing bacteria; Introduction; Molecular ecology of toxin-producing bacteria; Pathogenicity islands, horizontal gene transfer, and the prevalence of toxins; Toxins encoded by plasmids, bacteriophages, and other pathogenicity islands; PAI-encoded toxins delivered by specialized secretion systems 327 $aMolecular evolution of toxins through genetic exchangeGenetic exchange and toxin evolution; Toxin evolution and transmission in the host; Toxin evolution and transmission in the soil environment; Toxin evolution and transmission in aquatic environments; Toxin evolution and transmission in the phyllosphere; Toxin evolution in the guts of insects and other vectors; Toxin evolution in biofilms and regulation by quorum sensing; Vaccines and toxin evolution; Modular recombination of bacterial toxins; Conclusion; References 327 $a2 Mobile genetic elements and pathogenicity islands encoding bacterial toxinsIntroduction: The genome structure of prokaryotes; Protein toxins encoded by mobile genetic elements; Protein toxins encoded by plasmids; Gram-negative bacteria; Gram-positive bacteria; Protein toxins encoded by bacteriophages; Gram-negative bacteria; Gram-positive bacteria; Protein toxin genes and other mobile genetic elements; Toxins encoded by PAIs; PAIs; PAI-encoded toxins; Enterobacteria; Other Gram-negative bacteria; The bacterial T6SS; Gram-positive bacteria; Instability of PAIs; Conclusion 327 $aEvolution of new pathogenic variants caused by PAIs and mobile genetic elementsHGT and the evolution of toxin families; Acknowledgments; References; 3 News and views on protein secretion systems; Introduction; Most historical secretion types; Type I secretion system; Type II secretion system; Type III secretion system; Type IV secretion system: a protein and DNA transport machine; Type V secretion system: free or surface-bound?; Type VI secretion system: weapon for bacterial warfare; How far can we go with secretion types?; Type VII secretion system 327 $aExtracellular appendages and secretion typesThe type IX secretion system; What about other secretion concepts?; Bacteriocins, colicins, pyocins, contact-dependent inhibition; Cell surface lipoproteins; OM Vesicles; What about Gram-positive bacteria, then?; Closing remarks; References; II. Intracellularly Alive Bacterial Protein Toxins; 4 Diphtheria toxin; Introduction; Diphtheria toxin: from pathology to crystal structure; Symptoms, treatment, prophylaxis, and epidemiology of diphtheria; History of DT research; Regulation of DT production; The structure of DT; The mechanism of action of DT 327 $aThe main steps of cell intoxication 330 $aThe Comprehensive Sourcebook of Bacterial Protein Toxins 4th Edition, contains chapters written by internationally known and well-respected specialists. This book contains chapters devoted to individual toxins, as well as chapters that consider the different applications of these toxins. Considerable progress has been made in understanding the structure, function, interaction and trafficking into cells, as well as mechanism of action of toxins. Bacterial toxins are involved in the pathogenesis of many bacteria, some of which are responsible for severe diseases in human and animals, but can al 606 $aBacterial toxins 615 0$aBacterial toxins. 676 $a528.2039474 700 $aAlouf$b J. E$g(Joseph E.),$0880602 702 $aLadant$b Daniel 702 $aPopoff$b Michel R. 702 $aAktories$b K. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910583473403321 996 $aThe comprehensive sourcebook of bacterial protein toxins$91966654 997 $aUNINA