LEADER 02542nam 2200397 450 001 9910583400403321 005 20230120002721.0 010 $a0-12-809719-1 010 $a0-12-809518-0 035 $a(CKB)4100000004687211 035 $a(MiAaPQ)EBC5430246 035 $a(EXLCZ)994100000004687211 100 $a20180623d2018 uy 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 14$aThe cellular secretome and organ crosstalk /$fJurgen Eckel 210 1$aSan Diego, California :$cElsevier,$d2018. 215 $a1 online resource (242 pages) 327 $aGeneral introduction -- Adipose tissue : a major secretory organ -- Skeletal muscle : a novel secretory organ -- Adipomyokines : an extended view on the crosstalk scenario -- Secretory malfunction : a key step to metabolic diseases -- Technical annex. 330 $aThe Cellular Secretome and Organ Crosstalk focuses on the release of peptides and proteins from different organs and their specific functions in metabolic regulation and cell- and organ crosstalk. The book is written for experts in the field, however, for each topic, helpful references are included. The book also includes technical sections that summarize the state-of-the-art of secretome and crosstalk analysis. This book fulfills the need for a resource that comprehensively describes the current knowledge of secretome biology in health and disease. Communication between different organs involves lipids and other small molecules and a host of proteins and peptides comprising the secretome of different organs (organokinome). More than 600 adipokines have been identified, and an increasing number of hepatokines and myokines have recently been discovered with mostly unknown physiological impact. Importantly, an aberrant signature of the organokinome may be critically underlying a variety of metabolic diseases and may determine the individual susceptibility to disease development. Summarizes our current knowledge on the secretome of different cells and tissues.--$cSource other than the Library of Congress. 606 $aCytology 606 $aMetabolism$xRegulation 615 0$aCytology. 615 0$aMetabolism$xRegulation. 676 $a571.6 700 $aEckel$b Juergen$0954190 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910583400403321 996 $aThe cellular secretome and organ crosstalk$92158058 997 $aUNINA