LEADER 05403nam 2200661 450 001 9910583358103321 005 20230120011423.0 010 $a0-7020-4268-4 035 $a(CKB)2660000000010991 035 $a(EBL)2072157 035 $a(SSID)ssj0001535786 035 $a(PQKBManifestationID)11860576 035 $a(PQKBTitleCode)TC0001535786 035 $a(PQKBWorkID)11502846 035 $a(PQKB)11484270 035 $a(MiAaPQ)EBC2072157 035 $a(EXLCZ)992660000000010991 100 $a20150701h20152015 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aClinical equine oncology /$fDerek C. Knottenbelt, Janet C. Patterson-Kane, Katie L. Snalune 210 1$aEdinburgh, [Scotland] :$cElsevier,$d2015. 210 4$dİ2015 215 $a1 online resource (715 p.) 300 $aDescription based upon print version of record. 311 $a0-7020-4266-8 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aFront cover; Clinical Equine Oncology; Copyright page; Table of Contents; Preface; Acknowledgements; Dedication; Glossary; Specialist terms used in radiotherapy; I Basic principles of oncology; 1 Introduction; References; 2 The challenges and problems of equine oncological practice; References; 3 Tumour nomenclature; Introduction; Benign and malignant tumours; Benign tumours; Malignant tumours; Assessing tumour activity and behaviour in vitro and in vivo; Grading; Staging; TNM tumour staging; Measured/assessed parameters; Ann Arbor tumour staging; Reference; 4 Biology of tumour growth 327 $aThe molecular and genetic (cellular) basis of cancerThe guardian of the genome: (T)p53 gene; DNA repair genes; Cell destruction; Apoptosis; Cellular evasion of apoptosis; Autophagy; Necrosis; Immune evasion; The role of calreticulin in tumour development; Cellular senescence; Cell interactions; Carcinogenesis; The Knudson hypothesis; The multistep carcinogenesis proposal; Chemical carcinogenesis; Radiation carcinogenesis; Microbiological/infectious agents of carcinogenesis; Other factors that promote tumour development; Tumour progression and proliferation; Angiogenesis; Tumour invasion 327 $aThe stromal micro-environment of a tumourMetastasis; The genetic theory of metastasis; Routes of metastasis; The growth of tumours; The Gompertzian model; References; 5 Clinical effects of cancer in horses; Introduction; Clinical signs and consequences; Tissue type; Size/extent; Location; Number; Specific nature and pathological behaviour; Functionality; Duration; Differential diagnoses; Ulceration and infection; Physical appearance; References; 6 Paraneoplastic syndromes; Anorexia-cachexia and wasting syndromes; Tumour lysis syndrome; Hypercalcaemia/hypocalcaemia; Pyrexia; Anaemia 327 $aErythrocytosis (polycythaemia)Thrombocytosis/thrombocytopaenia; Hypoglycaemia; Hypercupraemia; Hyperfibrinogenaemia, hyperglobulinaemia and monoclonal gammopathy; Paraneoplastic pruritus; Paraneoplastic pemphigus and other dermatological paraneoplastic signs; Ulcerative coronitis; Paraneoplastic bullous stomatitis; Protein-losing enteropathy; Renal failure; Amyloidosis; Hypertrophic (pulmonary) osteopathy (Marie's disease); References; 7 Principles of diagnosis; Clinical investigations and specialized tests/imaging methods; Tissue sampling; Biopsy; Overview; Biopsy methods; Punch biopsy 327 $aWedge biopsyPortional biopsy; Excisional/ablative biopsy; Fine-needle aspiration; Hollow-needle biopsy; Impression smears; Tissue fixatives; Haematology and biochemistry; Ultrasonography; Abdominocentesis/thoracocentesis; Total protein assay; Cytological assessment; Cerebrospinal fluid sampling; Bone marrow biopsy/aspiration; Bone marrow aspiration; Bone marrow biopsy; Technique; Radiography; X-ray computed tomography (CT); Magnetic resonance imaging (MRI); Scintigraphy; Laparoscopy/pleuroscopy/endoscopy; Technique; Limitations; Tumour markers; In vitro cell culture assessment; References 327 $a8 Pathological methods in equine oncology 330 $aDiagnose common equine tumors accurately and find clinical information quickly! Clinical Equine Oncology describes the cellular basis of cancer and its etiopathogenesis, along with the principles of diagnosis, treatment, and management of cancer cases. This comprehensive resource offers more than just facts and diagrams - hundreds of detailed photographs make it easier to recognize and evaluate more than 50 types of tumors. It's useful to anyone working in the equine field, whether you're a veterinary surgeon, a practicing vet, equine dentist, or veterinary student. Written by a recognized ex 606 $aOncology 606 $aTumors 606 $aCancer$xTreatment 606 $aNeoplasms$xveterinary 606 $aHorse Diseases 615 0$aOncology. 615 0$aTumors. 615 0$aCancer$xTreatment. 615 12$aNeoplasms$xveterinary. 615 12$aHorse Diseases. 676 $a636.10896994 700 $aKnottenbelt$b Derek C.$0513506 702 $aPatterson-Kane$b Janet C. 702 $aSnalune$b Katie L. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910583358103321 996 $aClinical equine oncology$92157095 997 $aUNINA