LEADER 04884nam 2200577 450 001 9910583344503321 005 20230120002710.0 010 $a0-12-811083-X 010 $a0-12-811060-0 035 $a(CKB)4100000000972625 035 $a(MiAaPQ)EBC5124555 035 $a(EXLCZ)994100000000972625 100 $a20171211h20182018 uy 0 101 0 $aeng 135 $aurcnu|||||||| 181 $2rdacontent 182 $2rdamedia 183 $2rdacarrier 200 00$aEpigenetics of aging and longevity /$fedited by Alexey Moskalev, Alexander Vaiserman 210 1$aLondon, England :$cAcademic Press,$d2018. 210 4$dİ2018 215 $a1 online resource (546 pages) $cillustrations 225 1 $aTranslational Epigenetics Series ;$vVolume 4 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $tAging epigenetics : changes and challenges /$rDuygu Ucar and Be?re?nice A. Benayoun --$tDefective DNA methylation/demethylation processes define aging-dependent methylation patterns /$rMichele Zampieri, Fabio Ciccarone, Paola Caiafa --$tS-adenosylmethionine metabolism and aging /$rWil A.M. Loenen --$tThe epigenetic clock and aging /$rKen Raj --$tThe epigenetic regulation of telomere maintenance in aging /$rHuda Adwan-Shekhidem and Gil Atzmon --$tLiving long and aging well : are lifestyle factors the epigenetic link in the longevity phenotype? /$rIrene Maeve Rea and Ken I. Mills --$tEpigenetic biomarkers for biological age /$rArnold B. Mitnitski --$tThe role of non-coding RNAs in genome stability and aging /$rIgor Kovalchuk --$tIntra-tissue DNA methylation heterogeneity in aging /$rJan Vijg, Silvia Gravina, Xiao Dong --$tEarly-life nutrition, epigenetics and altered energy balance later in life /$rClare M Reynolds, Justin M O'Sullivan, Stephanie A. Segovia, Mark H. Vickers --$tEarly nutrition, epigenetics and human health /$rSimon C. Langley-Evans and Beverly S. Muhlhausler --$tBiological embedding of psychosocial stress over the life course /$rHelen Eachus and Vincent T. Cunliffe --$tEpigenetics of longevity in social insects /$rAlexander M. Vaiserman, Oleh V. Lushchak and Alexander K. Koliada --$tDrosophila melanogaster as a model for studying the epigenetic basis of aging /$rIlya Solovyov, Mikhail Shaposhnikov, Anna Kudryavtseva, Alexey Moskalev --$tHistone modification changes during aging : cause or consequence? What we have learned about epigenetic regulation of aging from model organisms /$rXiaohua Cao and Weiwei Dang --$tEpigentics of brain/cognitive aging /$rXiangru Xu --$tThe role of epigenetic modifications in cardiometabolic diseases /$rKim V.E. Braun, Eliana Portilla, Rajiv Chowdhury, Jana Nano, Jenna Troup, Trudy Voortman, Oscar H. Franco, Taulant Muka --$tEpigenetic mechanisms in osteoporosis /$rBarbara Ostanek, Tilen Kranjc, Nika Lovs?in, Janja Zupan, Janja Marc --$tEpigenetics of skeletal muscle aging /$rAdam P. Sharples, Robert A. Seaborne, Claire E. Stewart --$tHealthy aging and epigenetic drugs for diabetes and obesity : a novel perspective /$rSunitha Meruvu, John D. Bowman, Mahua Choudhury --$tEpigenetic drugs for cancer and precision medicine /$rMukesh Verma, Vineet Kumar --$tEpigenetic drug discovery for Alzheimer's disease /$rRamo?n Cacabelos, Oscar Teijido --$tEpigenetics of aging and longevity : challenges and future directions /$rAxel Schumacher. 330 $a"Epigenetics of Aging and Longevity provides an in-depth analysis of the epigenetic nature of aging and the role of epigenetic factors in mediating the link between early-life experiences and life-course health and aging. Chapters from leading international contributors explore the effect of adverse conditions in early life that may result in disrupted epigenetic pathways, as well as the potential to correct these disrupted pathways via targeted therapeutic interventions. Epigenetic drug discovery, and the role of epigenetic mechanisms in regulating specific age-associated illnesses, including cancer and cardiovascular, metabolic, and neurodegenerative diseases, are explored in detail."--$cBack cover. 410 0$aTranslational epigenetics series. 606 $aEpigenetics 606 $aEpigenesis 606 $aLongevity 606 $aEpigenesis, Genetic 606 $aAging$xgenetics 606 $aLongevity$xgenetics 606 $aEpigenomics 615 0$aEpigenetics. 615 0$aEpigenesis. 615 0$aLongevity. 615 12$aEpigenesis, Genetic. 615 22$aAging$xgenetics. 615 22$aLongevity$xgenetics. 615 22$aEpigenomics. 676 $a572.865 702 $aMoskalev$b Alexey 702 $aVaiserman$b Alexander 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910583344503321 996 $aEpigenetics of aging and longevity$92097173 997 $aUNINA