LEADER 04637nam 2200565 450 001 9910583334903321 005 20201211215432.0 010 $a0-12-802990-0 010 $a0-12-802973-0 035 $a(CKB)3710000000848862 035 $a(EBL)4689270 035 $a(MiAaPQ)EBC4689270 035 $a(PPN)197276687 035 $a(EXLCZ)993710000000848862 100 $a20161005h20162016 uy| 0 101 0 $aeng 135 $aur|n|---||||| 181 $2rdacontent 182 $2rdamedia 183 $2rdacarrier 200 00$aNeuroepidemiology /$fvolume editors Caterina Rosano, M. Arfan Ikram, and Mary Ganguli 210 1$aAmsterdam :$cElsevier,$d[2016] 210 4$dİ2016 215 $a1 online resource (352 p.) 225 1 $aHandbook of clinical neurology ;$v3rd series, volume 138 300 $aDescription based upon print version of record. 320 $aIncludes bibliographical references and index. 327 $aFront Cover; Neuroepidemiology; Copyright; Handbook of Clinical Neurology 3rd Series; Foreword; Preface; Contributors; Contents; Section 1: Principles and foundations of epidemiology and neurology research; Chapter 1: Epidemiology for the clinical neurologist; What is epidemiology?; Uses of epidemiology; Making a community diagnosis; Measurement of disease in populations: prevalence vs. incidence; Prevalence; Incidence; What is the relationship between prevalence and incidence?; Incidence; Prevalence; Mortality; Completing the clinical picture; The importance of sampling; Random sampling 327 $aSample sizep-value; Power; Effect size; Making inferences from the sample to the population; Normal distribution and confidence limits; Identifying causal/risk factors; Observational studies; Descriptive studies; Ecologic studies; Cross-sectional studies; Case-control studies; Cohort studies; Nested case-control studies; Experimental studies; Randomized controlled trials; Field trials; Community trials; Measures of association; Odds ratio; Relative risk or risk ratio; Timing and duration of exposure; Sources of error in epidemiologic studies; Bias; Selection bias; Information/measurement bias 327 $aConfoundingEstablishing causality in epidemiologic studies; Computing individual risk; Screening tests; Charting historic trends; Cohort effects; Delineating new syndromes; Evaluating health services; Misuses of epidemiology; Summary; References; Chapter 2: Population neuroscience; Genes and gene regulation; Physical and social environment; Geographic Information Systems; Aggregate data; Cohort member; Brain structure and function; Brain structure; T1-weighted images; Diffusion tensor imaging; Magnetic transfer imaging; Brain function; Reproducibility; Interpretation 327 $aDirectionality of structure-function relationshipsFunctional and structural connectivity; Future directions; Conclusions; Acknowledgments; References; Chapter 3: Advanced epidemiologic and analytical methods; Introduction; Relevance of critical appraisal in observational epidemiology; Relevance of critical appraisal in analytic epidemiology; The scopes of neuroepidemiology; Life-course epidemiology; Definitions and key concepts; Main purpose(s); Causal pathways; Timing; Explanatory mechanisms; Methods in life-course epidemiology; Study designs and type of data needed; Formulating hypothesis 327 $aSteps of statistical analysis in life-course epidemiologyFurther examples of sources of errors and bias in epidemiologic studies; Two-phase designs; Use of medical records to ascertain outcome status and information/measurement bias; Competing risks and informative censoring; Mediation; References; Chapter 4: Basics of neuroanatomy and neurophysiology; Cellular structure and function; Neurons; Neurotransmission; Neurotransmitters; Glia; Brain structure; Gray matter and white matter; White-matter lesions; Functional systems; Sensory systems: visual, auditory, chemosensory, somatic systems 327 $aVisual system 410 0$aHandbook of clinical neurology ;$v3rd se., v. 138. 606 $aNervous system$xDiseases$xEpidemiology 606 $aNervous System Diseases$xepidemiology 606 $aEpidemiologic Methods 615 0$aNervous system$xDiseases$xEpidemiology. 615 12$aNervous System Diseases$xepidemiology. 615 22$aEpidemiologic Methods. 702 $aRosano$b Caterina 702 $aIkram$b M. Arfan 702 $aGanguli$b Mary 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910583334903321 996 $aNeuroepidemiology$92062543 997 $aUNINA