LEADER 02773nam 2200409 450 001 9910583314503321 005 20230120002502.0 035 $a(CKB)3710000000984151 035 $a(MiAaPQ)EBC4773657 035 $a(EXLCZ)993710000000984151 100 $a20170110h20172017 uy 0 101 0 $aeng 135 $aurcnu|||||||| 181 $2rdacontent 182 $2rdamedia 183 $2rdacarrier 200 10$aDNA modifications in the brain $eneuroepigenetic regulation of gene expression /$fTimothy Bredy 210 1$aAmsterdam, [Netherlands] :$cAcademic Press,$d2017. 210 4$dİ2017 215 $a1 online resource (182 pages) $cillustrations, tables 311 $a0-12-801596-9 311 $a0-12-801781-3 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aPreface -- History and modern view on DNA modifications in the brain / B.F. Vanyushin and V.V. Ashapkin -- Approaches to detecting DNA base modification in the brain / X. Li and W. Wei -- Active DNA demethylation in neurodevelopment / Y. Kang, Z. Wang and P. Jin -- TET and 5hmC in neurodevelopment and the adult brain / M. Fasolino, S.A. Welsh and Z. Zhou -- Beyond mCG : DNA methylation in noncanonical sequence context / E.A. Mukamel and R. Lister -- DNA modifications and memory / J.J. Day -- Measuring CpG methylation by SMRT sequencing / Y. Suzuki, J. Korlach and S. Morishita -- Epigenetic modifications of DNA and drug addiction / J. Feng and E.J. Nestler -- What does the future hold for the study of nucleic acid modifications in the brain? / P.R. Marshall and T.W. Bredy. 330 $aBegins with an historical overview of the early discoveries surrounding DNA methylation in the mammalian brain and then explores the evidence supporting a role for this epigenetic mechanism in controlling gene expression programs across the lifespan in both normal and diseased states. Chapters describe new directions and technological advances, and provide an overview of what the future holds for this exciting new field. This book is ideal for medical, graduate and advanced undergraduate students, but is also a great resource for researchers who need a broad introduction to the dynamic nature of DNA that sheds light on evolving concepts of gene-environment interaction and their effects on adaptation and neuropsychiatric disease.--$cSource other than the Library of Congress. 606 $aGene expression 615 0$aGene expression. 676 $a574.87322 700 $aBredy$b Timothy$0889937 702 $aBredy$b Timothy W. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910583314503321 996 $aDNA modifications in the brain$91988353 997 $aUNINA