LEADER 04775nam 2200589 450 001 9910583092503321 005 20201211215713.0 010 $a0-7020-4537-3 010 $a0-444-53485-7 035 $a(CKB)3710000000748369 035 $a(EBL)4592086 035 $a(MiAaPQ)EBC4592086 035 $a(PPN)19553509X 035 $a(EXLCZ)993710000000748369 100 $a20160810h20162016 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $2rdacontent 182 $2rdamedia 183 $2rdacarrier 200 00$aNeuroimaging$hPart I /$fvolume editors, Joseph C. Masdeu, R. Gilberto Gonzalez 210 1$aAmsterdam, Netherlands :$cElsevier,$d2016. 210 4$dİ2016 215 $a1 online resource (724 p.) 225 1 $aHandbook of Clinical Neurology ;$vVolume 135 300 $aDescription based upon print version of record. 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aFront Cover; Neuroimaging Part I; Copyright; Handbook of Clinical Neurology 3rd Series; Foreword; Preface; Contributors; Contents of Part I; Contents of Part II; Section 1: Neuroimaging methods; Chapter 1: Computed tomography imaging and angiography - principles; Computed tomography imaging and angiography: principles; Introduction; Principles; Noncontrast computed tomography (NCCT); Computed tomography angiography (CTA); CT/CTA selected technical-clinical pearls and pitfalls; Stroke - technical pearls and pitfalls; Nontraumatic intracranial hemorrhage - technical pearls and pitfalls 327 $aNew developments and future directions; Dual-energy CT (DECT); Iterative reconstruction algorithms; References; Chapter 2: MR imaging: deconstructing timing diagrams and demystifying k-space; Introduction; Spin localization; Spin synchronization; Concept of an echo and k-space; A closer look at image space and k-space; Image detection and resolution considerations; Parallel imaging; A word about contrast; k-Space mapping strategies; Conclusions; References; Chapter 3: Volumetric and fiber-tracing MRI methods for gray and white matter; Introduction; Brain macrostructure and microstructure 327 $aQuantitative volumetric brain analysis: segmentation; Structural segmentation methods; Imaging requirements; Sources of error; Analysis of brain segmentation results; Volumetric analysis; Surface analysis; Segmentation methods: practical approaches; Segmentation workflow; Brain segmentation systems; Applications of brain segmentation analysis; Evaluation of normal aging; Neurodegenerative disease; Alzheimer's disease; Frontotemporal dementia; Epilepsy; Quantitative analysis of white-matter integrity: diffusion and tractographic analysis; Introduction; Local diffusion analysis 327 $aRegional diffusion analysis: tractography; Diffusion MRI methods; Application of diffusion MRI in the evaluation of white-matter integrity; Local dMRI measures of white-matter integrity and injury; Local measures of dMRI in demyelinating disease; Local measures of dMRI changes in normal aging; Local measures of dMRI in neurodegenerative disease; Regional measures of white-matter integrity: tractography; Tractography: axonal patterning; Tractography: brain connectivity; Tractography: applications; Diffusion MRI and tractography methods: practical approaches 327 $aDiffusion MRI and tractography workflows; Diffusion MRI and tractography systems; Future developments; Summary; References; Chapter 4: Functional magnetic resonance imaging; Introduction; Physiologic principles underlying bold fMRI; Metabolic and hemodynamic signals are surrogates for neural activity; Neurometabolic and neurovascular coupling; Synaptic activity dominantly drives signaling-related energy metabolism; Classic model: neural activity is linearly coupled to CMRGlc, CMRO2, and CBF; Experiment: at rest neural activity is linearly coupled to CMRO2, CMRGlc, and CBF 327 $aExperiment: with activation, neural activity is nonlinearly coupled to CMRGlc and CBF, but nearly linearly coupled to CMRO2 410 0$aHandbook of clinical neurology ;$vVolume 135. 606 $aNervous system$xImaging 606 $aNervous system$xDiseases$xImaging 606 $aNervous System Diseases$xdiagnosis 606 $aNeuroimaging$xmethods 615 0$aNervous system$xImaging. 615 0$aNervous system$xDiseases$xImaging. 615 12$aNervous System Diseases$xdiagnosis. 615 22$aNeuroimaging$xmethods. 676 $a616.804754 702 $aMasdeu$b Joseph C. 702 $aGonzalez$b R. Gilberto 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910583092503321 996 $aNeuroimaging$91751159 997 $aUNINA