LEADER 03752nam 2200409 450 001 9910583071403321 005 20221122002509.0 010 $a0-12-812560-8 010 $a0-12-812347-8 035 $a(CKB)4100000004531239 035 $a(MiAaPQ)EBC5426717 035 $a(PPN)233903755 035 $a(EXLCZ)994100000004531239 100 $a20180628d2018 uy 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aBipolar disorder vulnerability $eperspectives from pediatric and high-risk populations /$fedited by Jair C. Soares, Consuelo Walss-Bass, Paolo Brambilla 210 1$aLondon :$cAcademic Press,$d2018. 215 $a1 online resource (290 pages) 327 $aThe bipolar prodrome -- Staging models and neuroprogression in bipolar disorder -- Influence of early childhood trauma on risk for bipolar disorder -- Gene-environment interactions in high-risk populations -- Genetic risk in adult family members of patients with bipolar disorder -- Neurobiological markers of stress in youth at risk for bipolar disorder -- Neurobiological markers of stress in youth at risk for bipolar disorder -- Neuroimaging findings in youth at risk for bipolar disorder -- Neurocognitive findings in youth at high risk for bipolar disorder: potential endophenotypes? -- Neuropsychological and social cogitive function in young people at genetic risk of bipolar disorder -- Cognitive and neural basis of hypomania: perspectives for early detection of bipolar disorder -- Early pharmacological interventions in youth -- Psychological interventions in offspring of parents with bipolar disorder -- Summary and integration of current findings: a model for bipolar disorder development 330 $aBipolar Disorder Vulnerability: Perspectives from Pediatric and High-Risk Populations synthesizes our current understanding of high-risk and pediatric populations to aid readers in identifying markers of vulnerability for the development of bipolar disorder, with an ultimate goal of the development of drug targets and other therapies for early diagnosis and treatment. The book provides readers with an understanding of biological and environmental factors influencing disease manifestation that will aid them in defining discrete clinical stages and, importantly, establish an empirical basis for the application of novel therapeutics in a phase of illness during which specific treatments could more effectively alter disease course. Whereas most of the literature available on the pathophysiological mechanisms of bipolar disorder focuses on chronically ill adult individuals, this represents the only book that specifically examines pediatric and high-risk populations. An estimated 30 to 60 percent of adult bipolar disorder patients have their disease onset during childhood, with early-onset cases representing a particularly severe and genetically loaded form of the illness.Highlights diverse translational methodologies, including functional and structural neuroimaging, neuropsychological testing and integrated genomicsExamines molecular trajectories in youth with bipolar disorder and unaffected youth at high risk for developing bipolar disorderExplores the interaction between genomic and environmental influences that shape behavior. 606 $aBipolar disorder$xEtiology 615 0$aBipolar disorder$xEtiology. 676 $a616.895 702 $aSoares$b Jair C. 702 $aWalss-Bass$b Consuelo 702 $aBrambilla$b Paolo 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910583071403321 996 $aBipolar disorder vulnerability$92031028 997 $aUNINA