LEADER 04945oam 2200565 450 001 9910583038803321 005 20210111215559.0 010 $a0-12-809928-3 010 $a0-12-809912-7 035 $a(CKB)4100000003486426 035 $a(OCoLC)1033603987 035 $a(MiAaPQ)EBC5377542 035 $a(Au-PeEL)EBL5377542 035 $a(CaPaEBR)ebr11552966 035 $a(OCoLC)1035519773 035 $a(PPN)233903445 035 $a(EXLCZ)994100000003486426 100 $a20180812h20182018 uy 0 101 0 $aeng 135 $aurcn#nnn||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 04$aThe epigenetics of autoimmunity /$fedited by Rongxin Zhang, Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China 210 1$aLondon :$cAcademic Press an imprint of Elsevier,$d2018. 210 4$dİ2018 215 $a1 online resource (xix, 411 pages) $cillustrations 225 1 $aTranslational epigenetics series ;$vvolume 5 320 $aIncludes bibliographical references and index. 327 $a1. The epigenetics of autoimmunity: an overview -- 2. Immune cell development and epigenetics -- 3. DNA methylation and histone modifications in autoimmunity -- 4. MicroRNA and T helper cell-mediated immune responses -- 5. Long noncoding RNAs in the immune response -- 6. Epigenetics of systemic lupus erythematosus -- 7. Rheumatoid arthritis and epigenetics -- 8. Epigenetic modifications in multiple sclerosis pathophysiology: potential diagnostic and therapeutic applications -- 9. Type 1 diabetes and epigenetics -- 10. Systemic sclerosis and epigenetics -- 11. Primary Sjogren's syndrome and epigenetics -- 12. Autoimmune thyroid diseases and epigenetics -- 13. The epigenetics of primary biliary cholangitis -- 14. Immune-mediated pulmonary disease and epigenetics -- 15. The epigenetics of autoimmunity and epigenetic drug discovery -- 16. Treatment of autoimmune diseases and prevention of transplant rejection and graft-versus-host disease by regulatory T cells: the state of the art and perspectives -- 17. Noncoding RNA-targeted therapeutics in autoimmune diseases: from bench to bedside -- 18. Future challenges and prospects for the epigenetics of autoimmunity. 330 $aThe Epigenetics of Autoimmunity covers a topic directly related to translational epigenetics. Via epigenetic mechanisms, a number of internal and external environmental risk factors, including smoking, nutrition, viral infection and the exposure to chemicals, could exert their influence on the pathogenesis of autoimmune diseases. Such factors could impact the epigenetic mechanisms, which, in turn, build relationship with the regulation of gene expression, and eventually triggering immunologic events that result in instability of immune system. Since epigenetic aberrations are known to play a key role in a long list of human diseases, the translational significance of autoimmunity epigenetics is very high. To bridge the gap between environmental and genetic factors, over the past few years, great progress has been made in identifying detailed epigenetic mechanisms for autoimmune diseases. Furthermore, with rapid advances in technological development, high-throughput screening approaches and other novel technologies support the systematic investigations and facilitate the epigenetic identification. This book covers autoimmunity epigenetics from a disease-oriented perspective and several chapters are presented that provide advances in wide-spread disorders or diseases such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), multiple sclerosis (MS), type 1 diabetes (T1DM), systemic sclerosis (SSc), primary Sji?A?½gren's syndrome (pSS) and autoimmune thyroid diseases (AITDs). These emerging epigenetic studies provide new insights into autoimmune diseases, raising great expectations among researchers and clinicians. This seminal book on this topic comprehensively covers the most recent advances in this exciting and rapidly developing new science. They might reveal not only new clinical biomarkers for diagnosis and disease progression, but also novel targets for potential epigenetic therapeutic treatment. 410 0$aTranslational epigenetics series ;$vvolume 5. 606 $aAutoimmunity$xMolecular aspects 606 $aAutoimmune diseases$xEtiology 606 $aEpigenesis 606 $aAutoimmunity 606 $aEpigenesis, Genetic$ximmunology 615 0$aAutoimmunity$xMolecular aspects. 615 0$aAutoimmune diseases$xEtiology. 615 0$aEpigenesis. 615 12$aAutoimmunity. 615 12$aEpigenesis, Genetic$ximmunology. 676 $a571.973 702 $aZhang$b Rongxin 801 0$bAuAdUSA 801 1$bAuAdUSA 906 $aBOOK 912 $a9910583038803321 996 $aThe epigenetics of autoimmunity$91990249 997 $aUNINA