LEADER 03015nam 2200409 450 001 9910583026303321 005 20230120002756.0 010 $a0-12-804268-0 010 $a0-12-804227-3 035 $a(CKB)4100000005956446 035 $a(MiAaPQ)EBC5495625 035 $a(EXLCZ)994100000005956446 100 $a20180919d2019 uy 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aRisk assessment for human metal exposures $emode of action and kinetic approaches /$fGunnar F. Nordberg, Bruce A. Fowler 205 $aFirst edition. 210 1$aLondon, United Kingdom :$cAcademic Press, an imprint of Elsevier,$d[2019] 210 4$dİ2019 215 $a1 online resource (350 pages) 327 $aMetal exposures and human health -- historical development, current importance, and toxicological concepts for prevention -- Exposure, internal dose, and toxicokinesis (TK) -- Biomonitoring, mode of action (MOA), target dose, and adverse outcome pathways (AOPs) -- Hazard identification and assessment -- Dose-effect and dose-response assessment -- Dose-response for essential metals and the evaluation of mixed exposures -- Applied risk assessment, hazard assessment, and risk management -- Examples of risk assessments of human metal exposures and the need for mode of action (MOA), toxicokinetic-toxicodynamic (TKTD) modeling, and adverse outcome pathways (AOPs). 330 $aRisk Assessment for Human Metal Exposures: Mode of Action and Kinetic Approaches examines the current principles of risk assessment in human metal exposures, with a focus on Mode of Action(MOA), Toxicokinetic and Toxicodynamic (TKTD) considerations, and computer models. Derived from the highly respected Handbook on the Toxicology of Metals, Fourth Edition (2014), the book summarizes principles and methods and provides examples of how MOA -TKTD can be used. In addition, it presents tactics on how information generated by such methods can be confirmed by epidemiological data. Furthermore, it demonstrates how epidemiological data can be confirmed and evaluated by the examined models and considerations. This resource uniquely integrates several important topics, such as risk assessment, characterization, management and communication-the classic risk assessment paradigm-with mode of action, TKTD, and epidemiology, all topics related to human exposure. Written by pioneers in the field, this book is an essential reference for researchers, students and technicians in toxicology and risk assessment.--$cSource other than the Library of Congress. 606 $aMetals$xToxicology 615 0$aMetals$xToxicology. 676 $a615.9253 700 $aNordberg$b Gunnar$016460 702 $aFowler$b Bruce A. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910583026303321 996 $aRisk assessment for human metal exposures$91933233 997 $aUNINA