LEADER 01574nam 2200433 450 001 9910717043303321 005 20211227112925.0 035 $a(CKB)5470000002527774 035 $a(OCoLC)1290170456 035 $a(EXLCZ)995470000002527774 100 $a20211227d2021 ua 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aCBO's simulation model of new drug development /$fChristopher P. Adams 210 1$aWashington, D.C. :$cCongressional Budget Office,$d2021. 215 $a1 online resource (28 pages, 1 unnumbered page) $ccolor illustrations 225 1 $aWorking paper ;$v2021-09 300 $a"August 2021." 320 $aIncludes bibliographical references (pages 26-28). 517 3 $aCongressional Budget Office's simulation model of new drug development 606 $aDrug development$zUnited States$xSimulation methods 606 $aPrescription pricing$xGovernment policy$zUnited States 606 $aPharmaceutical policy$zUnited States 606 $aDrugs$xPrices$zUnited States 615 0$aDrug development$xSimulation methods. 615 0$aPrescription pricing$xGovernment policy 615 0$aPharmaceutical policy 615 0$aDrugs$xPrices 700 $aAdams$b Christopher P.$01387614 712 02$aUnited States.$bCongressional Budget Office, 801 0$bGPO 801 1$bGPO 906 $aBOOK 912 $a9910717043303321 996 $aCBO's simulation model of new drug development$93438940 997 $aUNINA LEADER 03815nam 2201093z- 450 001 9910580205303321 005 20220706 035 $a(CKB)5690000000012035 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/87477 035 $a(oapen)doab87477 035 $a(EXLCZ)995690000000012035 100 $a20202207d2022 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aParadox Role of Oxidative Stress in Cancer$eState of the Art 210 $aBasel$cMDPI - Multidisciplinary Digital Publishing Institute$d2022 215 $a1 online resource (214 p.) 311 08$a3-0365-4421-6 311 08$a3-0365-4422-4 330 $aReactive oxygen species (ROS) are produced by healthy cells and are maintained at physiological levels by antioxidant systems. However, when ROS increase in number, a condition of oxidative stress occurs, leading to many human diseases, including cancer. The relationship between oxidative stress and cancer is complex since ROS play a double-edged role in cancer development and under therapy response. This paradox represents a great challenge for researchers and needs to be investigated. The articles collected in this Special Issue can help to clarify the role of ROS modulation in cancer prevention and treatment, and to dissect the molecular mechanisms underlying its paradoxical role in order to counteract carcinogenesis or enhance sensitivity to anticancer therapy. 517 $aParadox Role of Oxidative Stress in Cancer 606 $aMedicine and Nursing$2bicssc 606 $aOncology$2bicssc 610 $aantitumor agents 610 $aapoptosis 610 $abioinorganic chemistry 610 $abiomarker 610 $abreast cancer treatment 610 $acancer progression 610 $acancer stem cells 610 $acancer therapy 610 $acancer treatment 610 $acancerogenesis 610 $acarbon doped titanium dioxide 610 $achemoresistance 610 $acold atmospheric plasma 610 $acombined treatment 610 $acoordination polymers 610 $aDNA damage 610 $aEprenetapopt 610 $aErastin 610 $aferroptosis 610 $aglutathione 610 $aglutathione (GSH) 610 $aGPX4 610 $ahematological malignancies 610 $aHO-1 610 $ahyperforin 610 $aHypericum perforatum 610 $aimmune system 610 $ainflammatory signaling 610 $airon 610 $aleukemia 610 $alipid peroxidation 610 $alymphoma 610 $amitochondria 610 $amultiple myeloma 610 $an/a 610 $anatural compounds 610 $anitrite 610 $aNrf2 610 $aNRF2 610 $aoral cancer 610 $aoxidative stress 610 $apancreatic cancer 610 $apatients 610 $apH regulation 610 $aprognosis 610 $aradiotherapy 610 $areactive oxygen and nitrogen species 610 $areactive oxygen species 610 $aSLC7A11 610 $asonodynamic therapy 610 $asonosensitizers 610 $atherapy 610 $atumor prevention 610 $atumor therapy 610 $aultrasound 610 $aultraviolet-C (UVC) 610 $awithanolide 610 $aZEB-1 615 7$aMedicine and Nursing 615 7$aOncology 700 $aDomenicotti$b Cinzia$4edt$01329334 702 $aMarengo$b Barbara$4edt 702 $aDomenicotti$b Cinzia$4oth 702 $aMarengo$b Barbara$4oth 906 $aBOOK 912 $a9910580205303321 996 $aParadox Role of Oxidative Stress in Cancer$93039443 997 $aUNINA