LEADER 04863oam 2200469 450 001 9910137090803321 005 20230621141039.0 010 $a9782889196326 (ebook) 035 $a(CKB)3710000000824740 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/44958 035 $a(EXLCZ)993710000000824740 100 $a20191103c2015uuuu uu- | 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aDevelopments in bovine immunology$b[electronic resource] $ean integrated view /$fedited by Kieran G. Meade 210 $cFrontiers Media SA$d2015 210 1$aFrance :$cFrontiers Media SA,$d2015 215 $a1 online resource (102 pages) $cillustrations, charts 225 1 $aFrontiers Research Topics 320 $aIncludes bibliographical references. 330 $aThe world?s population is predicted to hit 9 Billion by 2050, and with it food demand is predicted to increase substantially. The World Bank estimates that cereal and meat production needs to increase by 50% and 85% respectively between 2000 and 2030 to meet demand, putting serious pressure on the global agricultural industry. Critical to meeting this demand for food are mechanisms to reduce the incidence of animal disease. With in excess of 1.3 billion cattle globally, the total cost of infectious diseases is difficult to estimate. However in North America alone, the cost is predicted to be $18 billion annually. Non-infectious diseases also account for another major impediment to the production capacity and welfare of animals as well as the economic sustainability of farming. However animal diseases have implications that spread far beyond the farm gate. Infectious agents can also contaminate the food chain, and potentially affect human health.Controlling diseases, through better preventative and treatment methods requires a detailed understanding of the immune response in livestock species. Multiple studies have identified associations between variation in immune genes and disease susceptibility, which potentially opens up new avenues to select animals with superior disease resistance. Detailed understanding of immunity in cattle is leading to the design of more effective vaccines. Furthermore, appreciation of the significant differences between rodent and human immune responses has also led to bovine models being developed for some human diseases.The publication of the bovine genome and the advent of next-generation sequencing technologies have facilitated a massive expansion in our knowledge of the immune response in cattle. As a result there has been an explosion of exciting research findings including in metagenomics and epigenetics. Recently, there has been a welcome move to integrate our emerging understanding of the immune response with detailed studies of other important physiological processes including nutrition and reproduction. The interactions between the reproductive system, nutrition and the immune system are of particular interest, since each places significant demands on the animal at various stages through the production cycle. The interplay between these morphologically diffuse systems involves widely distributed chemical signals in response to environmental input, and each system must interact for the normal functioning of the other. A comprehensive ?systems? approach is improving our understanding of normal physiological interactions between these systems and furthermore, how dysregulation can lead to disease.The successful translation of bovine immunological research into improved treatments for animal disease requires tight interaction between diverse scientific and clinical disciplines including immunology, microbiology, endocrinology, physiology, nutrition, reproduction and clinical veterinary medicine. With so much recent progress in the field, we believe that it is valuable and well-timed to review the broad variety of the relevant studies that attempt to increase our understanding through comprehensive collaboration between these disciplines.We are looking forward to a wide and vivid discussion of developments in bovine immunology and related issues, and we expect that our readers profoundly benefit from new exciting insights and fruitful collaborations. 606 $aBovine studies 606 $aImmunology 610 $aPregnancy 610 $aMastits 610 $aM bovis 610 $amiRNAs 610 $aBovine Immunology 610 $aMap 610 $aimmunobiotics 610 $aOne Health 615 0$aBovine studies. 615 0$aImmunology. 676 $a636.2/0896 700 $aKieran G. Meade$4auth$01364594 801 0$bUkMaJRU 912 $a9910137090803321 996 $aDevelopments in bovine immunology$93386019 997 $aUNINA LEADER 02012nam 2200361z- 450 001 9910490718403321 005 20250320053048.0 035 $a(CKB)5590000000533388 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/71142 035 $a(oapen)doab71142 035 $a(EXLCZ)995590000000533388 100 $a20||||||d2019 |y 0 101 0 $afre 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aLe mouvement peut-il gue?rir? Les usages me?dicaux de la gymnastique au 19e?me sie?cle 210 $aLausanne$cBHMS Editions$d2019 215 $a1 online resource 225 1 $aBibliothèque d'histoire de la médecine et de la santé 311 08$a9782940527083 311 08$a2940527083 330 $aCet ouvrage offre une plonge?e encore ine?dite dans la richesse de la vie me?dicale et scientifique qui se de?ploie autour des questions hygie?niques, orthope?diques et gymnastiques dans la premie?re moitie? du 19e sie?cle. En effet, a? ce moment, une nouvelle modernite? me?dicale voit le jour et nous nous trouvons dans un ve?ritable « moment orthope?dique » au regard de l'engagement des me?decins autour de l'e?laboration d'une gymnastique me?dicale. Dans ce cadre, les luttes sont alors au moins aussi nombreuses que les accords the?rapeutiques. Re?alise? dans le cadre d'une consultation exhaustive de la production discursive des me?decins francophones, ce livre est e?galement une introduction a? une histoire sociale de la me?decine et une invitation a? des re?flexions plus larges sur les liens entre exercices du corps et sante?. 610 $aGymnastique 610 $aHistoire 610 $aMe?decine 610 $aMouvement 700 $aQuin$b Grégory$4auth$01297000 906 $aBOOK 912 $a9910490718403321 996 $aLe mouvement peut-il guérir? Les usages médicaux de la gymnastique au 19ème siècle$93024386 997 $aUNINA LEADER 04633nam 2201441z- 450 001 9910580203103321 005 20220706 035 $a(CKB)5690000000012059 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/87430 035 $a(oapen)doab87430 035 $a(EXLCZ)995690000000012059 100 $a20202207d2022 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aTherapeutic Potential of Plant Secondary Metabolites in the Treatment of Diseases and Drug Development 210 $aBasel$cMDPI - Multidisciplinary Digital Publishing Institute$d2022 215 $a1 online resource (334 p.) 311 08$a3-0365-3881-X 311 08$a3-0365-3882-8 330 $aThe importance of natural products, and especially plant secondary metabolites, for the treatment of diseases and drug development has already been obvious in medicine for several thousand years. Thus, this Special Issue of MDPI Biomedicines collects eight top articles from the field as regular full papers in addition to five reviews. All of the published papers are a vibrant source of information on the therapeutic potential of plant secondary metabolites in the treatment of diseases and drug development. 606 $aIndustrial chemistry and chemical engineering$2bicssc 606 $aTechnology: general issues$2bicssc 610 $aalkaloids 610 $aamide bond 610 $aanabolic 610 $aanti-HIV activity 610 $aantimicrobial activity 610 $aantiviral therapy 610 $aartemisinin 610 $abetulinic acid 610 $abevirimat 610 $abioavailability 610 $aBODIPY 610 $acancer 610 $acancer cells 610 $acannabichromene 610 $acannabidiol (CBD) 610 $acannabinoid receptors (CB1 and CB2) 610 $acannabinoids 610 $aCannabis sativa (Cannabis) 610 $acapsaicinoids 610 $acardiometabolic diseases 610 $acell-cycle 610 $achloroquine 610 $aCOVID-19 610 $acurcumin 610 $acurcumin analogues 610 $acurcumin delivery systems 610 $acurcumin derivatives 610 $acytotoxicity 610 $adiabetes 610 $aDuchenne muscular dystrophy 610 $aecdysteroid 610 $aecdysterone 610 $aEGFR 610 $aendocannabinoidome 610 $afluorescent microscopy 610 $afood intake 610 $aHuisgen 1,3-dipolar cycloaddition 610 $ainflammation 610 $aivermectin 610 $alignans 610 $alipid accumulation 610 $alipidomics 610 $alipogenesis 610 $alung cancer 610 $aLXR? 610 $aMAFLD 610 $amalaria 610 $aMas1 610 $amaturation inhibitor 610 $amembrane fusion 610 $ametabolism 610 $amicrobiota 610 $aMMP2 610 $amolecular ribbon 610 $amoxidectin 610 $amultifunctional PEG3 derivative 610 $an/a 610 $anatural product 610 $anatural product synthesis 610 $anatural remedy 610 $aNF-?B inhibition 610 $aNSCLC 610 $aobesity 610 $aonchocerciasis 610 $aosteoporosis 610 $aoverweight 610 $aPapaver somniferum (opium poppy) 610 $aPD-L1 610 $aphytocannabinoids 610 $aphytochemical 610 $aquinine 610 $arespiratory diseases 610 $asarcopenia 610 $aSARS-CoV-2 610 $asecondary metabolites 610 $aSTAT3 610 $asupramolecular self-assembly 610 $atanshinone IIA 610 $atetrahydrocannabinol (THC) 610 $athermos-TRPs 610 $atriterpenoid 610 $aTRPA1 610 $atumorsphere 610 $aUnited States Food and Drug Administration-approved drug 610 $aursolic acid 610 $avinblastine 610 $avincristine 610 $aviral fusion inhibitor 610 $a?,?-dimethylheptyl effect 610 $a?-ecdysone 615 7$aIndustrial chemistry and chemical engineering 615 7$aTechnology: general issues 700 $aDras?ar$b Pavel B$4edt$01303416 702 $aDras?ar$b Pavel B$4oth 906 $aBOOK 912 $a9910580203103321 996 $aTherapeutic Potential of Plant Secondary Metabolites in the Treatment of Diseases and Drug Development$93027019 997 $aUNINA