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001 9910580146703321
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010   $a3-031-06850-5
024 7 $a10.1007/978-3-031-06850-8
035   $a(MiAaPQ)EBC7021893
035   $a(Au-PeEL)EBL7021893
035   $a(CKB)24056041100041
035   $aEBL7021893
035   $a(AU-PeEL)EBL7021893
035   $a(PPN)270268464
035   $a(OCoLC)1333445629
035   $a(DE-He213)978-3-031-06850-8
035   $a(EXLCZ)9924056041100041
100   $a20220624d2022      u|         0
101 0 $aeng
135   $aurcnu||||||||
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aAntiprotozoal Drug Development and Delivery /$fedited by Alane Beatriz Vermelho, Claudiu T. Supuran
205   $a1st ed. 2022.
210  1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2022.
215   $a1 online resource (333 pages)
225 1 $aTopics in Medicinal Chemistry,$x1862-247X ;$v39
300   $aDescription based upon print version of record.
311 08$aPrint version: Vermelho, Alane Beatriz Antiprotozoal Drug Development and Delivery Cham : Springer International Publishing AG,c2022 9783031068492 
327   $aClassical and Modern Drug Treatments for Leishmaniasis -- Saponins as Potential Antiprotozoa Agents -- Chagas Disease: Drug Development and Parasite Target -- Targeting carbonic anhydrases from Leishmania spp. and Trypanosoma cruzi as a strategy to obtain new drugs -- New Compounds for the Management of Trypanosoma brucei Infection -- Polyamine and Trypanothione Pathways as Targets for Novel Antileishmanial Drugs -- Nano and Microstructured Delivery Systems for Current Antileishmanial Drugs -- Pharmacological Treatment of Malaria -- ?-Class Carbonic Anhydrases as Antiplasmodial Drug Targets: Current State of the Art and Hurdles to Develop New Antimalarials -- Management of Entamoeba histolytica Infection: Treatment Strategies and Possible New Drug Targets -- Trichomonas vaginalis Pharmacological Treatment -- Beta-Carbonic Anhydrase from Trichomonas Vaginalis as New Antiprotozoan Drug Target -- Drugs for the treatment of toxoplasmosis -- Challenges and promises for obtaining new antiprotozoal drugs ? what?s going wrong?
330   $aThis book reviews new promising drug targets for Neglected Tropical Diseases (NTDs), with a special focus on antiprotozoal drugs against trpyanosomatids Trypanosoma cruzi and Leishmania spp. The book offers a comprehensive overview of the most recent studied targets, and it outlines classical and new treatments and delivery strategies. Expert contributors describe new methods of analysis and bio-prospecting for new compounds, and provide a critical perspective of the translational process used in the research and development of new drug candidates. The book will appeal not only to researchers, students and professionals interested in drug development to protozoan diseases, but also to medicinal chemists in general.
410  0$aTopics in Medicinal Chemistry,$x1862-247X ;$v39
606   $aPharmaceutical chemistry
606   $aSynthetic biology
606   $aMedical microbiology
606   $aParasitology
606   $aMedicine, Preventive
606   $aHealth promotion
606   $aBioinformatics
606   $aMedicinal Chemistry
606   $aSynthetic Biology
606   $aMedical Microbiology
606   $aParasitology
606   $aHealth Promotion and Disease Prevention
606   $aComputational and Systems Biology
615  0$aPharmaceutical chemistry.
615  0$aSynthetic biology.
615  0$aMedical microbiology.
615  0$aParasitology.
615  0$aMedicine, Preventive.
615  0$aHealth promotion.
615  0$aBioinformatics.
615 14$aMedicinal Chemistry.
615 24$aSynthetic Biology.
615 24$aMedical Microbiology.
615 24$aParasitology.
615 24$aHealth Promotion and Disease Prevention.
615 24$aComputational and Systems Biology.
676   $a615.7
676   $a616.9883
702   $aSupuran$b Claudiu T.
702   $aVermelho$b Alane Beatriz
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9910580146703321
996   $aAntiprotozoal drug development and delivery$92997520
997   $aUNINA