LEADER 04082nam 2200961z- 450 001 9910576881203321 005 20231214133056.0 035 $a(CKB)5720000000008363 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/84448 035 $a(EXLCZ)995720000000008363 100 $a20202206d2022 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aDown Syndrome$eNeuropsychological Phenotype across the Lifespan 210 $aBasel$cMDPI - Multidisciplinary Digital Publishing Institute$d2022 215 $a1 electronic resource (180 p.) 311 $a3-0365-3962-X 311 $a3-0365-3961-1 330 $aDown syndrome (DS), caused by the triplication of chromosome 21, is the most common genetic cause of intellectual disability (ID). Individuals with DS commonly exhibit unique neuropsychological profiles that emerge during specific developmental stages across the lifespan, often characterized by early developmental delay, cognitive strengths and weaknesses, behavior and mental health issues, and age-related cognitive decline, frequently resulting in early-onset Alzheimer?s disease. These profiles are unique compared to other individuals with ID and reflect the genetic mechanisms and neuroanatomic features underlying the distinct neuropsychological phenotype associated with DS. This Special Issue aims to highlight the recent advancements in understanding the neuropsychological phenotype associated with DS across the lifespan. The lifespan perspective will cover four developmental stages: (1) early childhood; (2) school age; (3) young adulthood, and (4) older adulthood. Authors contributed cutting-edge original research studies and comprehensive reviews that address a broad range of topics related to DS, including early developmental trajectories, cognitive functioning, language, adaptive skills, behavior and mental health, assessment and diagnosis, age-related cognitive decline, and medical issues related to the neuropsychological phenotype and neuroimaging. 517 $aDown Syndrome 606 $aMedicine$2bicssc 606 $aNeurosciences$2bicssc 610 $atrisomy 21 610 $adecoding 610 $avocabulary 610 $aletters 610 $aphonological awareness 610 $adown syndrome 610 $afluency 610 $adisfluency 610 $aco-occurrence 610 $acomorbidity 610 $alanguage 610 $aDown syndrome 610 $asocial cognition 610 $asocial behavior 610 $ameasurement 610 $achildren 610 $aattention 610 $aaudiovisual processing 610 $acommunicative abilities in infants 610 $aTrisomy 21 610 $aindependence 610 $atransition to adulthood 610 $aproxy-report 610 $aregression 610 $aAlzheimer's disease 610 $abiomarkers 610 $adementia 610 $acognition 610 $afunctional independence 610 $aneuropsychological assessment 610 $aprimary care 610 $ascreening 610 $aearly regression 610 $aidiopathic regression 610 $adepression 610 $aselective serotonin reuptake inhibitor 610 $amild cognitive impairment 610 $acognitive decline 610 $aneuropsychological tests 610 $acognitive function 610 $aearly-onset Alzheimer disease 610 $alate-onset Alzheimer disease 610 $ahypothyroidism 610 $athyroid autoantibodies 610 $aTSH 610 $aFree T4 610 $aAPOE ?4 610 $aautism spectrum disorder 610 $aco-occurring 610 $aprevalence 615 7$aMedicine 615 7$aNeurosciences 700 $aPulsifer$b Margaret B$4edt$01294323 702 $aPulsifer$b Margaret B$4oth 906 $aBOOK 912 $a9910576881203321 996 $aDown Syndrome$93023148 997 $aUNINA