LEADER 04488nam 2201369z- 450 001 9910576879603321 005 20220621 035 $a(CKB)5720000000008379 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/84428 035 $a(oapen)doab84428 035 $a(EXLCZ)995720000000008379 100 $a20202206d2022 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aPhospholipases: From Structure to Biological Function 210 $aBasel$cMDPI - Multidisciplinary Digital Publishing Institute$d2022 215 $a1 online resource (348 p.) 311 08$a3-0365-4064-4 311 08$a3-0365-4063-6 330 $aPhospholipases are a ubiquitous group of enzymes that hydrolyze ester bonds within membrane phospholipids. These enzymes serve multiple biological functions that go far beyond a mere membrane remodeling role in cellular homeostasis; they also play key functions in nutrient digestion and the regulated formation of bioactive lipids involved in cell signaling. It is to the latter function, critical to life, that this book is primarily concerned with. All the chapters are written by renowned experts in the area, and provide forefront information on the role phospholipases in a number of physiological and pathophysiological settings. 517 $aPhospholipases 606 $aBiology, life sciences$2bicssc 606 $aResearch & information: general$2bicssc 610 $aacidic sphingomyelinase 610 $aadipokines 610 $aadrenic acid 610 $aalcoholic and nonalcoholic steatohepatitis 610 $aanti-inflammatory 610 $aarachidonic acid 610 $aatherosclerosis 610 $aautoinflammatory 610 $aautotaxin 610 $aceramide 610 $acholine and methionine deficiency 610 $achronic non-bacterial osteomyelitis 610 $achronic recurrent multifocal osteomyelitis 610 $acPLA2? 610 $acrotoxin 610 $acytokines 610 $adiacylglycerol 610 $adiet-induced obesity 610 $aEP receptors 610 $afatty acid 610 $afatty liver 610 $aG protein-coupled receptor 610 $aglioblastoma 610 $aglucose tolerance 610 $aGroup V phospholipase A2 610 $agroup VIA phospholipase A2 610 $ahepatocellular carcinoma 610 $ainflammasome 610 $ainflammation 610 $ainflammatory response 610 $ainhibitor 610 $ainsulin resistance 610 $ainsulin secretion 610 $aknockout mouse 610 $alipid mediator 610 $alipid mediators 610 $alipid signaling 610 $alipidomics 610 $alipids 610 $alipin 610 $aLIPIN2 610 $alipins 610 $aLPIN2 610 $alung impairment 610 $alysophosphatidate 610 $alysophospholipid 610 $amacrophage 610 $amacrophages 610 $amajeed syndrome 610 $amass spectrometry 610 $amembrane 610 $ametabolic stability 610 $ametastasis 610 $amonocytes/macrophages 610 $amorbidly obesity 610 $an/a 610 $aneuromuscular blocker 610 $aneutral sphingomyelinase 610 $aosteoclast 610 $aoxoesters 610 $apancreatic islets 610 $aPAP-2 610 $aphosphatidic acid 610 $aphospholipase A2 610 $aphospholipases 610 $aphospholipid 610 $aphospholipid remodeling 610 $aPLA2G6 610 $apreadipocytes 610 $aproliferation 610 $aprostaglandins 610 $apsoriasis 610 $asignaling 610 $asnake venom 610 $asphingolipid 610 $asphingomyelin 610 $asphingomyelinase 610 $asphingosine-1-phosphate 610 $aT cells 610 $a?-methylation 610 $a?-cells 615 7$aBiology, life sciences 615 7$aResearch & information: general 700 $aBalboa$b Mari?a A$4edt$01324799 702 $aBalsinde$b Jesu?s$4edt 702 $aBalboa$b Mari?a A$4oth 702 $aBalsinde$b Jesu?s$4oth 906 $aBOOK 912 $a9910576879603321 996 $aPhospholipases: From Structure to Biological Function$93036319 997 $aUNINA