LEADER 03057nam 2200457z- 450 001 9910220036503321 005 20210212 035 $a(CKB)3800000000216412 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/57927 035 $a(oapen)doab57927 035 $a(EXLCZ)993800000000216412 100 $a20202102d2017 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aReelin-Related Neurological Disorders and Animal Models 210 $cFrontiers Media SA$d2017 215 $a1 online resource (179 p.) 225 1 $aFrontiers Research Topics 311 08$a2-88945-111-9 330 $aThe Reeler mutation was so named because of the alterations in gait that characterize homozygous mice. Several decades after the description of the Reeler phenotype, the mutated protein was discovered and named Reelin (Reln). Reln controls a number of fundamental steps in embryonic and postnatal brain development. A prominent embryonic function is the control of radial neuronal migration. As a consequence, homozygous Reeler mutants show disrupted cell layering in cortical brain structures. Reln also promotes postnatal neuronal maturation. Heterozygous mutants exhibit defects in dendrite extension and synapse formation, correlating with behavioral and cognitive deficits that are detectable at adult ages. The Reln-encoding gene is highly conserved between mice and humans. In humans, homozygous RELN mutations cause lissencephaly with cerebellar hypoplasia, a severe neuronal migration disorder that is reminiscent of the Reeler phenotype. In addition, RELN deficiency or dysfunction is also correlated with psychiatric and cognitive disorders, such as schizophrenia, bipolar disorder and autism, as well as some forms of epilepsy and Alzheimer's disease. Despite the wealth of anatomical studies of the Reeler mouse brain, and the molecular dissection of Reln signaling mechanisms, the consequences of Reln deficiency on the development and function of the human brain are not yet completely understood. This Research Topic include reviews that summarize our current knowledge of the molecular aspects of Reln function, original articles that advance our understanding of its expression and function in different brain regions, and reviews that critically assess the potential role of Reln in human psychiatric and cognitive disorders. 606 $aNeurosciences$2bicssc 610 $aautism 610 $aDepression 610 $aintracellular pathways 610 $aNeuronal Death 610 $aneuronal migration 610 $aNeurons 610 $aReeler 610 $aSchizophrenia 610 $aSynapses 615 7$aNeurosciences 700 $aLaura Lossi$4auth$01331046 702 $aAdalberto Merighi$4auth 702 $aGabriella D'Arcangelo$4auth 906 $aBOOK 912 $a9910220036503321 996 $aReelin-Related Neurological Disorders and Animal Models$93040068 997 $aUNINA LEADER 03788nam 2200997z- 450 001 9910576877103321 005 20220621 035 $a(CKB)5720000000008404 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/84559 035 $a(oapen)doab84559 035 $a(EXLCZ)995720000000008404 100 $a20202206d2022 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aRecent Developments in Non-conventional Welding of Materials 210 $aBasel$cMDPI - Multidisciplinary Digital Publishing Institute$d2022 215 $a1 online resource (230 p.) 311 08$a3-0365-3873-9 311 08$a3-0365-3874-7 330 $aWelding is a technological field that has some of the greatest impact on many industries, such as automotive, aerospace, energy production, electronics, the health sector, etc. Welding technologies are currently used to connect the most diverse materials, from metallic alloys to polymers, composites, or even biological tissues. Despite the relevance and wide application of traditional welding technologies, these processes do not meet the demanding requirements of some industries. This has driven strong research efforts in the field of non-conventional welding processes. This Special Issue presents a sample of the most recent developments in the non-conventional welding of materials, which will drive the design of future industrial solutions with increased efficiency and sustainability. 606 $aHistory of engineering and technology$2bicssc 606 $aTechnology: general issues$2bicssc 610 $aAA6082-T6 610 $aadvanced methods 610 $aaluminium alloys 610 $aaustenitic and ferritic-pearlitic steels 610 $abobbin friction stir welding 610 $abutt joint 610 $acomposite 610 $acopper 610 $acreep 610 $adissimilar materials 610 $aEBSD 610 $aexplosive cladding 610 $aexplosive welding 610 $afatigue performance 610 $afracture 610 $afriction stir lap welding 610 $afriction stir welding 610 $aFSW 610 $ahigh entropy alloys 610 $ahigh temperature 610 $ahot rolling 610 $aintermetallic 610 $alaser beam welding 610 $alight alloys 610 $amechanical properties 610 $amicrostructure 610 $amicrostructure analysis 610 $an/a 610 $anumerical simulation 610 $aoptical microscopy 610 $aorbital hole-drilling strain-gauge method 610 $apin depth 610 $aprediction of tensile yield force 610 $aresidual stress 610 $asealed lap joints of dissimilar materials 610 $asolid type welding 610 $asteel 610 $astrain rate 610 $aT-joints 610 $athree dissimilar aluminum alloys 610 $atilt angle 610 $atool rotational speed 610 $atraverse and rotation speed 610 $atraverse force 610 $aweld 610 $aweld strength 610 $awelding joint properties 610 $awelding speed 610 $awelding techniques 610 $awelding zone microstructure 610 $aZr 700 615 7$aHistory of engineering and technology 615 7$aTechnology: general issues 700 $aLeal$b Rui Manuel$4edt$01300061 702 $aGalva?o$b Ivan$4edt 702 $aLeal$b Rui Manuel$4oth 702 $aGalva?o$b Ivan$4oth 906 $aBOOK 912 $a9910576877103321 996 $aRecent Developments in Non-conventional Welding of Materials$93025389 997 $aUNINA