LEADER 00934nam2-2200337---450 001 990005576170203316 005 20200831190315.0 035 $a000557617 035 $aUSA01000557617 035 $a(ALEPH)000557617USA01 035 $a000557617 100 $a19981214d1991430-|||y0itaa50------ba 101 $afre 102 $afr 105 $a0 00||| 200 1 $a<<1: Les >> Ecritures du moi$fGeorges Gusdorf 210 $aParis$cOdile Jacob$d1991 430 p. 215 $a430 p.$d24 cm 461 0$1001000557616$12001$aLignes de vie$v1 620 $dPARIS 700 1$aGUSDORF,$bGeorges$0142497 801 0$aIT$bSA$c20111219 912 $a990005576170203316 950 0$aDipar.to di Filosofia - Salerno$dDFCC 809.092$e264 FIL 951 $aCC 809.092$b264 FIL 959 $aBK 969 $aFIL 979 $c20121027$lUSA01$h1525 979 $c20121027$lUSA01$h1614 996 $aEcritures du moi$91131936 997 $aUNISA LEADER 04831nam 2201237z- 450 001 9910576875203321 005 20231214132825.0 035 $a(CKB)5720000000008423 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/84526 035 $a(EXLCZ)995720000000008423 100 $a20202206d2022 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aOpioids and Their Receptors$ePresent and Emerging Concepts in Opioid Drug Discovery II 210 $aBasel$cMDPI - Multidisciplinary Digital Publishing Institute$d2022 215 $a1 electronic resource (260 p.) 311 $a3-0365-4352-X 311 $a3-0365-4351-1 330 $aFew neurotransmitter systems have fascinated as much as the opioid system (i.e., opioid ligands and their receptors). Over the years, scientific studies of the endogenous opioid system have uncovered a complex and subtle system that exhibits impressive diversity, based on its critical role in modulating a large number of sensory, motivational, emotional and cognitive functions. Additionally, its important therapeutic value for the treatment of many human disorders, including pain, affective and addictive disorders, and gastrointestinal motility disorders, has been of persistent interest. This book specifically covers a broad area of the opioid research, offering up-to-date and new perspectives about opioid drug discovery. The diversity among the discussed topics ranging from medicinal chemistry to opioid pharmacology, from basic science to translational research, is a testimony to the complexity of the opioid system that results from the expression, regulation and functional role of opioid ligands and their receptors. This book will serve as a useful reference to scientists while also stimulating continuous research in the chemistry and pharmacology of the opioid system, with the prospective for finding improved therapies of human diseases where the opioid system plays a central role. 517 $aOpioids and Their Receptors 606 $aResearch & information: general$2bicssc 606 $aChemistry$2bicssc 610 $athiazole 610 $apiperazine 610 $atail-clip 610 $ahot-plate 610 $aacetic acid-induced writhing test 610 $aopioid 610 $aprodynorphin 610 $aepigenetics 610 $atranscription 610 $ahuman brain 610 $amorphine dosing 610 $abehavior 610 $alocomotor activity 610 $atolerance 610 $aµ-opioid receptor 610 $aDAMGO 610 $aSR-17018 610 $abuprenorphine 610 $analbuphine 610 $akappa opioid receptor agonist 610 $apruritis 610 $ascratching 610 $amice 610 $aTAT-HIV 610 $acholestasis 610 $achloroquine 610 $adeoxycholic acid 610 $aanalgesic 610 $a? opioid receptor 610 $aG-protein-biased agonist 610 $aopioid peptide 610 $arubiscolins 610 $aµ-opioid analgesics 610 $aangiotensin receptors 610 $achronic pain 610 $aneuropathic pain 610 $adelta opioid receptor 610 $ainverse agonist 610 $airreversible antagonist 610 $anon-competitive antagonist 610 $amolecular pharmacology 610 $afree fatty acid receptors 610 $alipids 610 $aopioid receptor 610 $acolitis 610 $achemotype 610 $ahigh-throughput screen 610 $aallosteric modulation 610 $abeta-arrestin 610 $amolecular dynamics 610 $aopioid receptors 610 $a?-amino acids 610 $apeptide synthesis 610 $areceptor binding studies 610 $afunctional assay 610 $anociceptin/orphanin FQ receptor 610 $aNOP receptor 610 $aligands 610 $anociceptin 610 $aN/OFQ 610 $aanalgesia 610 $aGPCR 610 $aHS-731 610 $aperipheral opioid agonist 610 $abinding 610 $aselectivity 610 $amolecular docking 610 $amolecular dynamics simulations 610 $afluorescence cross-correlation spectroscopy (FCCS) 610 $aG protein-coupled receptor (GPCR) 610 $aserotonin 615 7$aResearch & information: general 615 7$aChemistry 700 $aSpetea$b Mariana$4edt$01304705 702 $avan Rijn$b Richard M$4edt 702 $aSpetea$b Mariana$4oth 702 $avan Rijn$b Richard M$4oth 906 $aBOOK 912 $a9910576875203321 996 $aOpioids and Their Receptors$93027635 997 $aUNINA