LEADER 05742nam 2201909z- 450 001 9910576874303321 005 20220621 035 $a(CKB)5720000000008432 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/84569 035 $a(oapen)doab84569 035 $a(EXLCZ)995720000000008432 100 $a20202206d2022 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aAnticancer Drugs 2021 210 $aBasel$cMDPI - Multidisciplinary Digital Publishing Institute$d2022 215 $a1 online resource (594 p.) 311 08$a3-0365-4348-1 311 08$a3-0365-4347-3 330 $aThe Special Issue "Anticancer Drugs 2021" of Pharmaceuticals is focused on recent significant advances in the design, synthesis, molecular mechanism of action and therapeutic applications of anticancer drugs. This collection of preclinical research papers and reviews includes designed chemotherapeutic agents, targeted therapies and biological agents. The rationalization for the biological activity of these drugs is presented, which helps to guide the design of more effective agents. Structure-activity relationships, together with the biological context in which targets are selected for oncology drug development, are also considered. 606 $aChemistry$2bicssc 606 $aResearch & information: general$2bicssc 610 $a1,2,3-triazole 610 $a1,3,4-oxadiazole 610 $a3-amino-4'-guanidino 610 $a3,4'-bis-guanidino 610 $a5-fluoruracil 610 $a7-deaza-4'-thioadenosine derivatives 610 $aacetamide 610 $aadamantane 610 $aADC (antibody-drug conjugate) 610 $aage 610 $aalkylated 610 $aanticancer 610 $aanticancer activity 610 $aanticancer agents 610 $aapoptosis 610 $aapoptosis induction 610 $aaromatase inhibitor 610 $aBcl-2 inhibitors 610 $abenzenesulfonamides 610 $abenzimidazole 610 $aBRAF 610 $abreast cancer 610 $acancer 610 $acancer cell viability 610 $acancer vaccine 610 $aCAR (chimeric antigen receptor) 610 $acardiotoxicity 610 $acarvedilol 610 $acell cycle analysis 610 $achalcone 610 $achalcones 610 $acolony formation 610 $acombretastatin A-4 610 $aconcentration-guided dosing 610 $acovalent binding 610 $aCovDock 610 $acumulative dose 610 $acyclophosphamide 610 $acytotoxic activity 610 $acytotoxic agents 610 $acytotoxicity 610 $adesigned multiple ligand 610 $adiphenyl ether 610 $aDNA fragmentation 610 $adocking 610 $adoxazosin 610 $adrug efflux 610 $adual inhibitors 610 $adual-targeting molecule 610 $aEGFR 610 $aELISA 610 $aenantioselective synthesis 610 $aentrectinib 610 $aexportin-1 610 $agastric adenocarcinoma 610 $ageneric product 610 $aH1299 610 $aHDAC inhibitors 610 $aHER2 610 $aheterocyclic compound 610 $ahistopathology 610 $aHL-60 610 $aHT-29 cells 610 $ahybrid compounds 610 $ahybrid molecule 610 $ahydrazide derivatives 610 $aimidazoles 610 $aImiquimod 610 $aimmunotherapy 610 $ain vitro 610 $ain vivo 610 $aindazole 610 $aIndole-based analogues 610 $ainflammation 610 $ainterleukin-6 610 $aintramolecular hydrogen bond 610 $aisolation 610 $akidney 610 $alarotrectinib 610 $aletrozole 610 $aMD simulations 610 $aMDA-MB-231 cells 610 $amechanism prediction 610 $amiR-21 610 $amitoxantrone 610 $amodel informed dosing 610 $aMTT cytotoxic assay 610 $aMUC1 610 $aMUC16 610 $amucin 610 $amulti-kinase inhibitor 610 $amultidrug resistance 610 $an/a 610 $aNaMSA 610 $anitrogen scaffolds 610 $aNTRK 610 $anucleoside 610 $aoxidative stress 610 $apatent review 610 $apemetrexed 610 $aphenstatin 610 $aphenyl pyridyl ether 610 $aphysiologically based pharmacokinetics 610 $aprotein kinase inhibitors 610 $aresin acid 610 $asolid/lipid nanoparticles 610 $asorafenib 610 $aSTAT inhibitors 610 $asynthesis 610 $aTDP1 610 $atestis 610 $athieno[2,3-d][1,2,3]triazine 610 $athiourea 610 $athymidylate synthase 610 $atissue-agnostic 610 $aToll-Like Receptor 610 $atoxicity 610 $aTrk 610 $aTrk fusion 610 $atrypan blue assay 610 $atryptophanol 610 $atubulin polymerisation inhibitor 610 $atumor spheroids 610 $atyrosil-DNA-phosphodiesterase 1 610 $aurinary bladder 610 $aUSFDA 610 $axanthone 615 7$aChemistry 615 7$aResearch & information: general 700 $aMeegan$b Mary J$4edt$01325230 702 $aO'Boyle$b Niamh M$4edt 702 $aMeegan$b Mary J$4oth 702 $aO'Boyle$b Niamh M$4oth 906 $aBOOK 912 $a9910576874303321 996 $aAnticancer Drugs 2021$93036711 997 $aUNINA