LEADER 06510nam 2201897z- 450 001 9910576873703321 005 20220621 035 $a(CKB)5720000000008438 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/84580 035 $a(oapen)doab84580 035 $a(EXLCZ)995720000000008438 100 $a20202206d2022 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aPPARs as Key Mediators of Metabolic and Inflammatory Regulation 210 $cMDPI - Multidisciplinary Digital Publishing Institute$d2022 215 $a1 online resource (456 p.) 311 08$a3-0365-4192-6 311 08$a3-0365-4191-8 330 $aMounting evidence suggests a bidirectional relationship between metabolism and inflammation. Molecular crosstalk between these processes occurs at different levels with the participation of nuclear receptors, including peroxisome proliferator-activated receptors (PPARs). There are three PPAR isotypes, ?, ?/?, and ?, which modulate metabolic and inflammatory pathways, making them key for the control of cellular, organ, and systemic processes. PPAR activity is governed by fatty acids and fatty acid derivatives, and by drugs used in clinics (glitazones and fibrates). The study of PPAR action, also modulated by post-translational modifications, has enabled extraordinary advances in the understanding of the multifaceted roles of these receptors in metabolism, energy homeostasis, and inflammation both in health and disease. This Special Issue of IJMS includes a broad range of basic and translational article, both original research and reviews, focused on the latest developments in the regulation of metabolic and/or inflammatory processes by PPARs in all organs and the microbiomes of different vertebrate species. 606 $aBiochemistry$2bicssc 606 $aBiology, life sciences$2bicssc 606 $aResearch and information: general$2bicssc 610 $aadipose tissue 610 $aAMPK 610 $aamygdala 610 $aatopic dermatitis 610 $abezafibrate 610 $abrain 610 $abrowning 610 $acancer 610 $acommon carotid artery occlusion 610 $acoregulator 610 $acorticotropin releasing hormone 610 $acoumarin 610 $acrystal structure 610 $acytomegalovirus 610 $adairy animals 610 $adepression 610 $adiabetes 610 $aDNA methylation 610 $adocking 610 $adoping control 610 $adual/pan agonist 610 $aelectroretinography 610 $aELISA 610 $aenergy homeostasis 610 $aexercise 610 $afatty acid oxidation 610 $afatty acids 610 $afenofibrate 610 $afenofibric acid 610 $afibroblast growth factor 21 610 $afluorescent ligand 610 $aGDF15 610 $agene transcription 610 $aglucose 610 $aGSK3787 610 $aGW0742 610 $ahepatic damage 610 $ahepatic sex-biased gene expression 610 $ahistone modification 610 $aHIV 610 $aimmunity 610 $aimmunohistochemistry 610 $ainfection 610 $ainflammation 610 $ainsulin resistance 610 $akidney fibrosis 610 $aligand 610 $alipid droplets 610 $alipid metabolism 610 $alipidomics 610 $alipopolysaccharide (LPS) 610 $aliver damage 610 $alung 610 $aM. leprae 610 $aM. tuberculosis 610 $ametabolic alterations 610 $ametabolic reprograming 610 $ametabolic syndrome 610 $amicroglia 610 $amicronutrients 610 $amiRNA 610 $amolecular docking 610 $amycobacteria 610 $an/a 610 $aneural stem cells 610 $aneurogenesis 610 $aneuroinflammation 610 $aneuropathology 610 $anitric oxide synthase 610 $anon-alcoholic fatty liver disease (NAFLD) 610 $anon-alcoholic steatohepatitis (NASH) 610 $anonalcoholic fatty liver disease (NAFLD) 610 $anorepinephrine 610 $anuclear factors 610 $anuclear receptor 610 $anuclear receptors 610 $anucleus accumbens 610 $anutrigenomics 610 $aobesity 610 $aoleoylethanolamide 610 $aP2Y2 receptor 610 $apalmitoylethanolamide 610 $apattern-recognition receptors 610 $apemafibrate 610 $aperoxisome 610 $aperoxisome proliferator-activated receptor 610 $aperoxisome proliferator-activated receptor alpha 610 $aperoxisome proliferator-activated receptor gamma (PPAR?) 610 $aperoxisome proliferator-activated receptors (PPAR) 610 $aperoxisome-proliferator-activated receptor 610 $aphagocytosis 610 $apharmacological targets 610 $aPPAR 610 $aPPAR gamma 610 $aPPARg 610 $aPPARs 610 $aPPAR? 610 $aPPAR? knockout 610 $aPPAR?/? 610 $aPPAR? 610 $aPPAR? ligand 610 $aPPRE 610 $aproliferation 610 $apsoriasis 610 $apulmonary arterial hypertension 610 $apulmonary artery 610 $aquercetin 610 $areal-time PCR 610 $aregulatory T cells 610 $aresveratrol 610 $aretinal ischemia 610 $ascreening 610 $asex dimorphism 610 $asignaling pathway 610 $askeletal muscle 610 $asubgenual prefrontal cortex 610 $asubstrate metabolism 610 $aTGF? 610 $atoll-like receptor 4 610 $atype 2 diabetes mellitus 610 $avascular injury 610 $aX-ray crystallography 610 $aZika 610 $a?-oxidation 615 7$aBiochemistry 615 7$aBiology, life sciences 615 7$aResearch and information: general 700 $aVa?zquez-Carrera$b Manuel$4edt$01311969 702 $aWahli$b Walter$4edt 702 $aVa?zquez-Carrera$b Manuel$4oth 702 $aWahli$b Walter$4oth 906 $aBOOK 912 $a9910576873703321 996 $aPPARs as Key Mediators of Metabolic and Inflammatory Regulation$93030636 997 $aUNINA