LEADER 09248nam 2200529 450 001 9910574046203321 005 20240221131808.0 010 $a981-19-1352-8 035 $a(MiAaPQ)EBC6995039 035 $a(Au-PeEL)EBL6995039 035 $a(CKB)22444504100041 035 $a(EXLCZ)9922444504100041 100 $a20221206d2022 uy 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aAdvances in brain imaging techniques /$fedited by Nirmal Mazumder, Gireesh Gangadharan, Yury V. Kistenev 210 1$aSingapore :$cSpringer,$d[2022] 210 4$d©2022 215 $a1 online resource (265 pages) 311 08$aPrint version: Mazumder, Nirmal Advances in Brain Imaging Techniques Singapore : Springer,c2022 9789811913518 320 $aIncludes bibliographical references. 327 $aIntro -- Preface -- Contents -- About the Editors -- 1: Optical Coherence Tomography in Brain Gliomas Detection and Peritumoral White Matter State Evaluation -- 1.1 Introduction -- 1.2 Visual and Quantitative Evaluation of OCT Data Obtained in Brain Tumors -- 1.3 OCT Images of White Matter, Cortex, and Brain Tumors -- 1.4 Identification of Tissue Type in Brain Gliomas Using OCT -- 1.4.1 Differentiation of Tumor and White Matter -- 1.4.2 Differentiation of Tumor and Gray Matter -- 1.5 OCT for Stereotactic Biopsy -- 1.6 Determination of Myelination State of White Matter by OCT -- 1.7 Artificial Intelligence and Machine Learning Application for OCT Images Classification -- 1.8 Conclusions -- References -- 2: Two Photon Fluorescence Lifetime Imaging of Reduced Nicotinamide Adenine Dinucleotide in Brain Research -- 2.1 Introduction -- 2.2 Instrumentation -- 2.2.1 Fluorescence Lifetime Measurement -- 2.3 NADH Biogenesis -- 2.3.1 NADH Biosynthesis Pathway -- 2.4 NADH Autofluorescence and Lifetime -- 2.5 Applications -- 2.6 Conclusion -- References -- 3: Types of Raman Scattering Techniques for Neurodegenerative Diseases -- 3.1 Introduction -- 3.2 Raman Techniques -- 3.2.1 Raman Spectroscopy -- 3.2.2 Surface-Enhanced Raman Spectroscopy (SERS) -- 3.2.3 Spontaneous Raman Microscopy -- 3.2.4 Coherent Anti-Stokes Raman Scattering (CARS) Microscopy -- 3.2.5 Stimulated Raman Scattering (SRS) Microscopy -- 3.2.6 Hyperspectral Raman Imaging -- 3.3 Conclusions -- References -- 4: Drosophila Brain Advanced Multiphoton Imaging -- 4.1 Introduction: Drosophila as an Animal Model for Brain Analysis -- 4.2 Functional Multiphoton Microscopy of the Drosophila Brain -- 4.2.1 Depth -- 4.2.2 High-Speed Volumetric Imaging -- 4.2.3 Functional Connectome -- 4.3 Adaptive Optics Multiphoton Microscopy for 3D Imaging Improvement. 327 $a4.4 Adaptive Optics Procedure for Drosophila Brain Enhanced Imaging -- 4.5 Conclusions -- References -- 5: Myelin Imaging -- 5.1 Myelin -- 5.2 Traditional Methods: Electron Microscopy, Immunohistochemistry, and Fluorescence Microscopy -- 5.3 Nonlinear Optics Solutions -- 5.4 Novel Solutions for Optical Microscopy -- 5.5 X-Rays -- References -- 6: Brainbow: Principle, Technique, and Applications -- 6.1 Introduction -- 6.2 Principle: Biology of Brainbow -- 6.3 Techniques Used in Brainbow -- 6.4 Brain Tissue Optical Clearing -- 6.5 Applications -- 6.5.1 Connectome Mapping -- 6.5.1.1 Mice -- 6.5.1.2 Drosophila -- 6.5.1.3 Zebrafish -- 6.5.2 Developmental Biology -- 6.5.3 Deciphering Neural Heterogenicity -- 6.5.4 Lineage Tracing in Developing Embryos -- 6.5.5 Neural Diseases and Disorders -- 6.6 Conclusion -- References -- 7: Photoacoustic Imaging of Brain -- 7.1 Introduction -- 7.1.1 Types of PA Instruments -- 7.2 Instrumentation -- 7.3 Photoacoustic Brain Disorders Imaging -- 7.3.1 Neurodegenerative Disease Studies -- 7.3.2 Ischemic Stroke Studies -- 7.3.3 Spinal Cord Injury Studies -- 7.3.4 Epilepsy Studies -- 7.3.5 Brain Tumors Detection -- 7.4 Conclusion -- References -- 8: Photodynamic Therapy of Brain Diseases -- 8.1 Introduction -- 8.2 Singlet Oxygen Generation in Living Cells -- 8.3 PDT of Brain Tumors -- 8.4 PDT and the Blood-Brain Barrier (BBB) Permeability -- 8.5 PDT-Induced Opening of the BBB and the Meningeal Lymphatic System -- 8.6 PDT for Preclinical Study of Stroke -- 8.7 Enhancement of Light Delivery to the Brain -- 8.8 Conclusion and Perspectives -- References -- 9: Advanced Magnetic Resonance Imaging (MRI) of Brain -- 9.1 Introduction -- 9.2 Basic Principle -- 9.3 Various MR Sequences -- 9.3.1 T1 Weighted Images (T1WI) -- 9.3.2 T2 Weighted Images (T2WI) -- 9.3.3 Fluid Attenuation Inversion Recovery (FLAIR) Sequence. 327 $a9.3.4 Diffusion Weighted Imaging (DWI) -- 9.3.5 Susceptibility Weighted Imaging (SWI) -- 9.3.6 MR Perfusion Imaging -- 9.3.6.1 Dynamic Susceptibility Contrast (DSC) MR Perfusion -- 9.3.6.2 Dynamic Contrast Enhanced (DCE) MR Perfusion -- 9.3.6.3 Arterial Spin Labelling (ASL) -- 9.3.6.4 Uses -- 9.3.7 Magnetic Resonance Spectroscopy (MRS) -- 9.3.8 Diffusion Tensor Imaging (DTI) -- 9.3.8.1 Uses -- 9.3.9 Functional MRI (fMRI) -- 9.4 Conclusion -- References -- 10: Indirect Imaging -- 10.1 Introduction -- 10.2 Immunohistochemistry (IHC) -- 10.3 Flow Cytometry -- 10.4 Enzyme-Linked Immunosorbent Assay (ELISA) -- 10.5 Next-Generation Sequencing (NGS) -- 10.6 Atomic Force Microscopy -- 10.7 Nuclear Magnetic Resonance (NMR) -- 10.8 Chromatography/Mass Spectrometry -- 10.9 Spectroscopy Using Electromagnetic Waves -- 10.10 Summary -- References -- 11: Multimodal Noninvasive Imaging Strategies for Clinically Monitoring Degenerative Disorders of the Brain -- 11.1 Introduction -- 11.2 Common Noninvasive Neuroimaging Modalities -- 11.3 Characterizing Neurodegeneration Using Noninvasive Imaging -- 11.3.1 Volumetry -- 11.3.2 Cortical Thickness -- 11.3.3 Specific Signature Changes in Different Disorders -- 11.4 Quantitative Parameters for Clinical Evaluation by Imaging -- 11.4.1 Ratio of Midbrain to Pons Area -- 11.4.2 Magnetic Resonance Parkinsonism Index (MRPI) -- 11.4.3 Modified Parkinsonism Index -- 11.4.4 Ratio of Intercaudate Distance to Inner Table Width -- 11.4.5 Anterior Ventricle-Intercaudate Ratio -- 11.5 Grading System for Evaluating Neural Degeneration Using Structural Imaging -- 11.5.1 Fazekas Scale -- 11.5.2 Global Cortical Atrophy (GCA) Scale -- 11.5.3 Scheltens´s Scale or Medial Temporal Lobe Atrophy (MTA) Score -- 11.5.4 Posterior Atrophy Score -- 11.6 Functional Mapping (fMRI) -- 11.7 Diffusion Tensor Imaging (DTI) and Neural Fiber Connectivity. 327 $a11.8 Vascular Dynamics: Arterial Spin Labeling -- 11.9 Dementia Imaging Matrix Parameters -- 11.10 Emerging Technique of Neuroimaging Genomics to Assess Brain Disorders -- 11.11 Conclusion -- References -- 12: Machine Learning Approach in Brain Imaging -- 12.1 Introduction -- 12.2 Brain Optical Imaging -- 12.3 Magnetic Resonance Imaging -- 12.3.1 MRI Modalities -- 12.3.2 MRI Image Preprocessing -- 12.3.2.1 Denoising -- 12.3.2.2 Inhomogeneity Correction -- 12.3.2.3 Skull-Stripping -- 12.3.2.4 Registration -- 12.3.2.5 Intensity Standardization -- 12.3.2.6 De-oblique -- 12.3.2.7 Re-orientation -- 12.3.2.8 Motion Compensation -- 12.4 Brain Pathologies -- 12.4.1 Brain Tumors -- 12.4.2 Disorders of Consciousness -- 12.4.3 Autism Spectrum Disorder -- 12.4.4 Alzheimer´s Disease -- 12.4.5 Multiple Sclerosis -- 12.4.6 Parkinson´s Disease -- References -- 13: Transgenic Brain Mapping Techniques in Drosophila melanogaster -- 13.1 Introduction -- 13.2 Brain Mapping Techniques in Drosophila -- 13.3 FLP/FRT System -- 13.4 Mosaic Analysis with Repressible Cell Marker (MARCM) System -- 13.5 Optic Lobe in Drosophila melanogaster -- 13.6 Neurotransmitter System in Insects -- 13.7 GABA-Mediated Inhibitory Neurons in the Visual System -- 13.8 Acetylcholine-Mediated Excitatory Neurons in the Visual System -- References -- 14: Behavioural Phenotyping to Study Cognitive and Non-cognitive Symptoms in the Rodent Model of Alzheimer´s Disease -- 14.1 Introduction -- 14.2 Spatial Memory Tasks -- 14.2.1 Morris Water Maze -- 14.2.2 Radial Arm Maze -- 14.2.3 Y-Maze -- 14.2.4 T-Maze -- 14.2.5 Object Recognition Test -- 14.2.6 Object Location Test -- 14.3 Anxiety -- 14.3.1 Open Field Test -- 14.3.2 Light/Dark (LD) Test -- 14.3.3 Elevated Plus Maze (EPM) -- 14.4 Social Behaviour -- 14.4.1 Three Chamber Test -- 14.4.2 Social Recognition Test -- 14.4.3 Five Trial Social Memory Assay. 327 $a14.5 Apathy -- 14.5.1 Burrowing Test -- 14.5.2 Nest Building Test -- 14.6 Aggression -- 14.6.1 Resident-Intruder Test -- 14.7 Depression -- 14.7.1 Forced Swim Test -- 14.7.2 Tail Suspension Test -- 14.7.3 Sucrose Preference Test -- 14.8 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