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100   $a20230516d2008      uy             0
101 0 $aeng
135   $aur|||||||||||
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aPurines as Transmitter Molecules $eElectrophysiological Studies on Purinergic Signalling in Different Cell Systems /$fElisabetta Coppi
210  1$aFirenze :$cFirenze University Press,$d2008.
215   $a1 online resource (xiv, 176 pages) $cillustrations
225 1 $aPremio Tesi di Dottorato
311   $a88-927-3789-9 
330   $aPurinergic nucleotides and nucleosides (ATP, ADP, AMP and adenosine) are essential intracellular metabolites involved in a number of cellular processes, from energy supply to protein phosphorylation. However, in the last years, several studies demonstrated their involvement in cell signalling by the activation of specific membrane receptors (P1 and P2) and their role as neurotransmitters began to be investigated. The present work was aimed to clarify the effects of purinergic neurotransmission in different cell systems by using electrophysiological techniques. Relevant results of this research include the observation that P1 and P2 receptors play a deleterious role during "in vitro" ischemia in the rat brain, and the first demonstration of P2 receptor expression and function in a line of adult human mesenchymal stem cells.
410  0$aPremio Tesi di dottorato.
517   $aPurines as Transmitter Molecules
606   $aNeurotransmitter receptors
606   $aPurines
615  0$aNeurotransmitter receptors.
615  0$aPurines.
676   $a599.0188
700   $aCoppi$b Elisabetta$01261369
801  0$bNjHacI
801  1$bNjHacl
906   $aBOOK
912   $a9910572193103321
996   $aPurines as transmitter molecules$92932646
997   $aUNINA