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024 7 $a10.1007/978-3-319-77736-8
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035   $a(DE-He213)978-3-319-77736-8
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100   $a20180626d2018      u|             0
101 0 $aeng
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181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 14$aThe Heterogeneity of Cancer Metabolism$b[electronic resource] /$fedited by Anne Le
205   $a1st ed. 2018.
210  1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2018.
215   $a1 online resource (186 pages)
225 1 $aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v1063
311   $a3-319-77735-1 
327   $aPart 1: The metabolism of cancer cells -- Chapter 1: Glucose Metabolism -- Chapter 2: Glutamine Metabolism -- Chapter 3: Amino Acid Metabolism -- Chapter 4: Lipid Metabolism -- Chapter 5: Epigenetics and oncometabolites -- Part 2: Heterogeneity of Cancer Metabolism - Chapter 1: Specific oncogenetic mutations lead to specific metabolic phenotypes within the same tissue of origin -- Chapter 2: Intratumoral heterogeneity of cancer cell metabolism  -- - Chapter 3: Differential metabolism in vitro and in vivo -- Part 3: Carcinoma associated fibroblasts -- Chapter 1: Characteristics of CAF's -- Chapter 2: Reverse Warbug EFF -- Chapter 3: Metabolic exchange between CAFs and cancer cells. .
330   $aGenetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.
410  0$aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v1063
606   $aCancer research
606   $aImmunology
606   $aCancer Research$3https://scigraph.springernature.com/ontologies/product-market-codes/B11001
606   $aImmunology$3https://scigraph.springernature.com/ontologies/product-market-codes/B14000
615  0$aCancer research.
615  0$aImmunology.
615 14$aCancer Research.
615 24$aImmunology.
676   $a616.99407
702   $aLe$b Anne$4edt$4http://id.loc.gov/vocabulary/relators/edt
906   $aBOOK
912   $a9910568280703321
996   $aThe Heterogeneity of Cancer Metabolism$92850889
997   $aUNINA