LEADER 08173nam 2202317z- 450 001 9910566476003321 005 20231214133517.0 035 $a(CKB)5680000000037619 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/81102 035 $a(EXLCZ)995680000000037619 100 $a20202205d2022 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aCreatine Supplementation for Health and Clinical Diseases 210 $aBasel$cMDPI - Multidisciplinary Digital Publishing Institute$d2022 215 $a1 electronic resource (562 p.) 311 $a3-0365-2155-0 311 $a3-0365-2156-9 330 $aCreatine plays a critical role in cellular metabolism, primarily by binding with phosphate to form phosphocreatine (PCr) as well as shuttling high-energy phosphate compounds in and out of the mitochondria for metabolism. Increasing the dietary availability of creatine increases the tissue and cellular availability of PCr, and thereby enhances the ability to maintain high-energy states during intense exercise. For this reason, creatine monohydrate has been extensively studied as an ergogenic aid for exercise, training, and sport. Limitations in the ability to synthesize creatine and transport and/or store dietary creatine can impair metabolism and is a contributor to several disease states. Additionally, creatine provides an important source of energy during metabolically stressed states, particularly when oxygen availability is limited. Thus, researchers have assessed the role of creatine supplementation on health throughout the lifespan, as well as whether creatine availability may improve disease management and/or therapeutic outcomes. This book provides a comprehensive overview of scientific and medical evidence related to creatine's role in metabolism, health throughout the lifespan, and our current understanding of how creatine can promote brain, heart, vascular and immune health; reduce the severity of musculoskeletal and brain injury; and may provide therapeutic benefits in glucose management and diabetes, cancer therapy, inflammatory bowel disease, and post-viral fatigue. 606 $aResearch & information: general$2bicssc 606 $aBiology, life sciences$2bicssc 606 $aFood & society$2bicssc 610 $aergogenic aids 610 $acellular metabolism 610 $aphosphagens 610 $asarcopenia 610 $acognition 610 $adiabetes 610 $acreatine synthesis deficiencies 610 $aconcussion 610 $atraumatic brain injury 610 $aspinal cord injury 610 $amuscle atrophy 610 $arehabilitation 610 $apregnancy 610 $aimmunity 610 $aanti-inflammatory 610 $aantioxidant 610 $aanticancer 610 $acreatine 610 $anutritional supplements 610 $afertility 610 $anewborn 610 $adevelopment 610 $abrain injury 610 $apost-viral fatigue syndrome 610 $achronic fatigue syndrome 610 $aGAA 610 $acreatine kinase 610 $adietary supplements 610 $aexercise 610 $askeletal muscle 610 $aglycemic control 610 $atype 2 diabetes mellitus 610 $aphosphorylcreatine 610 $adietary supplement 610 $aergogenic aid 610 $ayouth 610 $aathletes 610 $aosteoporosis 610 $aosteosarcopenia 610 $afrailty 610 $acachexia 610 $ainnate immunity 610 $aadaptive immunity 610 $ainflammation 610 $amacrophage polarization 610 $acytotoxic T cells 610 $atoll-like receptors 610 $avascular pathology 610 $acardiovascular disease 610 $aoxidative stress 610 $avascular health 610 $afemale 610 $amenstrual cycle 610 $ahormones 610 $aexercise performance 610 $amenopause 610 $amood 610 $achildren 610 $aheight 610 $aBMI-for-age 610 $astature-for-age 610 $agrowth 610 $aphosphocreatine 610 $acreatine transporter 610 $asupplementation 610 $atreatment 610 $aheart 610 $aheart failure 610 $aischemia 610 $amyocardial infarction 610 $aanthracycline 610 $acardiac toxicity 610 $aenergy metabolism 610 $acell survival 610 $abioinformatics 610 $asystems biology 610 $acellular allostasis 610 $adynamic biosensor 610 $apleiotropic effects of creatine (Cr) supplementation 610 $ainflammatory bowel diseases (IBD) 610 $aulcerative colitis 610 $aCrohn?s disease 610 $acreatine kinase (CK) 610 $aphosphocreatine (PCr) 610 $acreatine transporter (CrT) 610 $aintestinal epithelial cell protection 610 $aintestinal tissue protection 610 $acreatine perfusion 610 $aorgan transplantation 610 $aAdenosine mono-phosphate (AMP) 610 $aactivated protein kinase (AMPK) 610 $aliver kinase B1 (LKB1) 610 $amitochondrial permeability transition pore (mPTP) 610 $areactive oxygen species (ROS) 610 $aglucose transporter (GLUT) 610 $aT cell antitumor immunity 610 $ametabolic regulator 610 $acancer immunotherapy 610 $asupplements 610 $amuscle damage 610 $arecovery 610 $aimmobilization 610 $aatrophy 610 $amuscular dystrophy 610 $aamyotrophic lateral sclerosis 610 $aParkinson?s Disease 610 $acardiopulmonary disease 610 $amitochondrial cytopathy 610 $ahypertrophy 610 $aathletic performance 610 $aweightlifting 610 $aresistance exercise 610 $atraining 610 $amuscular power 610 $amuscular adaptation 610 $amuscle fatigue 610 $aadipose tissue 610 $amuscle strength 610 $aphysiological adaptation 610 $amitochondria 610 $athermogenesis 610 $aMAP kinase signaling system 610 $asodium-chloride-dependent neurotransmitter symporters 610 $asignal transduction 610 $aintradialytic creatine supplementation 610 $ahemodialysis 610 $amuscle 610 $aprotein energy wasting 610 $aclinical trial 610 $amuscle weakness 610 $achronic fatigue 610 $acognitive impairment 610 $adepression 610 $aanemia 610 $aresistance training 610 $asports nutrition 610 $astrength 610 $atoxicity 610 $amethylation 610 $ahyperhomocysteinemia 610 $aneuromodulation 610 $aMCDA 610 $amitochondriopathia 610 $acardiac infarction 610 $along COVID 610 $ahypoxia 610 $astroke 610 $aneurodegenerative diseases 610 $anoncommunicable disease 610 $aadenosine 5?-monopnophosphate-activated protein kinase 610 $aanthracyclines 610 $acreatine supplementation 610 $acardiac signaling 610 $acardiotoxicity 610 $adoxorubicin 610 $asoy 610 $avegetarian/vegan diet 610 $aamino acids 610 $adietary ingredients 610 $aperformance 615 7$aResearch & information: general 615 7$aBiology, life sciences 615 7$aFood & society 700 $aKreider$b Richard B$4edt$01303402 702 $aStout$b Jeffrey$4edt 702 $aKreider$b Richard B$4oth 702 $aStout$b Jeffrey$4oth 906 $aBOOK 912 $a9910566476003321 996 $aCreatine Supplementation for Health and Clinical Diseases$93027001 997 $aUNINA