LEADER 08184nam 2202329z- 450 001 9910566476003321 005 20220506 035 $a(CKB)5680000000037619 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/81102 035 $a(oapen)doab81102 035 $a(EXLCZ)995680000000037619 100 $a20202205d2022 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aCreatine Supplementation for Health and Clinical Diseases 210 $aBasel$cMDPI - Multidisciplinary Digital Publishing Institute$d2022 215 $a1 online resource (562 p.) 311 08$a3-0365-2155-0 311 08$a3-0365-2156-9 330 $aCreatine plays a critical role in cellular metabolism, primarily by binding with phosphate to form phosphocreatine (PCr) as well as shuttling high-energy phosphate compounds in and out of the mitochondria for metabolism. Increasing the dietary availability of creatine increases the tissue and cellular availability of PCr, and thereby enhances the ability to maintain high-energy states during intense exercise. For this reason, creatine monohydrate has been extensively studied as an ergogenic aid for exercise, training, and sport. Limitations in the ability to synthesize creatine and transport and/or store dietary creatine can impair metabolism and is a contributor to several disease states. Additionally, creatine provides an important source of energy during metabolically stressed states, particularly when oxygen availability is limited. Thus, researchers have assessed the role of creatine supplementation on health throughout the lifespan, as well as whether creatine availability may improve disease management and/or therapeutic outcomes. This book provides a comprehensive overview of scientific and medical evidence related to creatine's role in metabolism, health throughout the lifespan, and our current understanding of how creatine can promote brain, heart, vascular and immune health; reduce the severity of musculoskeletal and brain injury; and may provide therapeutic benefits in glucose management and diabetes, cancer therapy, inflammatory bowel disease, and post-viral fatigue. 606 $aBiology, life sciences$2bicssc 606 $aFood & society$2bicssc 606 $aResearch & information: general$2bicssc 610 $aactivated protein kinase (AMPK) 610 $aadaptive immunity 610 $aadenosine 5'-monopnophosphate-activated protein kinase 610 $aAdenosine mono-phosphate (AMP) 610 $aadipose tissue 610 $aamino acids 610 $aamyotrophic lateral sclerosis 610 $aanemia 610 $aanthracycline 610 $aanthracyclines 610 $aanti-inflammatory 610 $aanticancer 610 $aantioxidant 610 $aathletes 610 $aathletic performance 610 $aatrophy 610 $abioinformatics 610 $aBMI-for-age 610 $abrain injury 610 $acachexia 610 $acancer immunotherapy 610 $acardiac infarction 610 $acardiac signaling 610 $acardiac toxicity 610 $acardiopulmonary disease 610 $acardiotoxicity 610 $acardiovascular disease 610 $acell survival 610 $acellular allostasis 610 $acellular metabolism 610 $achildren 610 $achronic fatigue 610 $achronic fatigue syndrome 610 $aclinical trial 610 $acognition 610 $acognitive impairment 610 $aconcussion 610 $acreatine 610 $acreatine kinase 610 $acreatine kinase (CK) 610 $acreatine perfusion 610 $acreatine supplementation 610 $acreatine synthesis deficiencies 610 $acreatine transporter 610 $acreatine transporter (CrT) 610 $aCrohn's disease 610 $acytotoxic T cells 610 $adepression 610 $adevelopment 610 $adiabetes 610 $adietary ingredients 610 $adietary supplement 610 $adietary supplements 610 $adoxorubicin 610 $adynamic biosensor 610 $aenergy metabolism 610 $aergogenic aid 610 $aergogenic aids 610 $aexercise 610 $aexercise performance 610 $afemale 610 $afertility 610 $afrailty 610 $aGAA 610 $aglucose transporter (GLUT) 610 $aglycemic control 610 $agrowth 610 $aheart 610 $aheart failure 610 $aheight 610 $ahemodialysis 610 $ahormones 610 $ahyperhomocysteinemia 610 $ahypertrophy 610 $ahypoxia 610 $aimmobilization 610 $aimmunity 610 $ainflammation 610 $ainflammatory bowel diseases (IBD) 610 $ainnate immunity 610 $aintestinal epithelial cell protection 610 $aintestinal tissue protection 610 $aintradialytic creatine supplementation 610 $aischemia 610 $aliver kinase B1 (LKB1) 610 $along COVID 610 $amacrophage polarization 610 $aMAP kinase signaling system 610 $aMCDA 610 $amenopause 610 $amenstrual cycle 610 $ametabolic regulator 610 $amethylation 610 $amitochondria 610 $amitochondrial cytopathy 610 $amitochondrial permeability transition pore (mPTP) 610 $amitochondriopathia 610 $amood 610 $amuscle 610 $amuscle atrophy 610 $amuscle damage 610 $amuscle fatigue 610 $amuscle strength 610 $amuscle weakness 610 $amuscular adaptation 610 $amuscular dystrophy 610 $amuscular power 610 $amyocardial infarction 610 $aneurodegenerative diseases 610 $aneuromodulation 610 $anewborn 610 $anoncommunicable disease 610 $anutritional supplements 610 $aorgan transplantation 610 $aosteoporosis 610 $aosteosarcopenia 610 $aoxidative stress 610 $aParkinson's Disease 610 $aperformance 610 $aphosphagens 610 $aphosphocreatine 610 $aphosphocreatine (PCr) 610 $aphosphorylcreatine 610 $aphysiological adaptation 610 $apleiotropic effects of creatine (Cr) supplementation 610 $apost-viral fatigue syndrome 610 $apregnancy 610 $aprotein energy wasting 610 $areactive oxygen species (ROS) 610 $arecovery 610 $arehabilitation 610 $aresistance exercise 610 $aresistance training 610 $asarcopenia 610 $asignal transduction 610 $askeletal muscle 610 $asodium-chloride-dependent neurotransmitter symporters 610 $asoy 610 $aspinal cord injury 610 $asports nutrition 610 $astature-for-age 610 $astrength 610 $astroke 610 $asupplementation 610 $asupplements 610 $asystems biology 610 $aT cell antitumor immunity 610 $athermogenesis 610 $atoll-like receptors 610 $atoxicity 610 $atraining 610 $atraumatic brain injury 610 $atreatment 610 $atype 2 diabetes mellitus 610 $aulcerative colitis 610 $avascular health 610 $avascular pathology 610 $avegetarian/vegan diet 610 $aweightlifting 610 $ayouth 615 7$aBiology, life sciences 615 7$aFood & society 615 7$aResearch & information: general 700 $aKreider$b Richard B$4edt$01303402 702 $aStout$b Jeffrey$4edt 702 $aKreider$b Richard B$4oth 702 $aStout$b Jeffrey$4oth 906 $aBOOK 912 $a9910566476003321 996 $aCreatine Supplementation for Health and Clinical Diseases$93027001 997 $aUNINA