LEADER 05341nam 2201249z- 450 001 9910566470103321 005 20231214133010.0 035 $a(CKB)5680000000037679 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/81030 035 $a(EXLCZ)995680000000037679 100 $a20202205d2022 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aA Themed Issue in Honor of Professor Raphael Mechoulam: The Father of Cannabinoid and Endocannabinoid Research 210 $aBasel$cMDPI - Multidisciplinary Digital Publishing Institute$d2022 215 $a1 electronic resource (236 p.) 311 $a3-0365-3006-1 311 $a3-0365-3007-X 330 $aDuring the last 60 years the relevance of cannabis (Cannabis sativa or Cannabis indica) ingredients, like the psychoactive ?9-tetrahydrocannabinol (THC), cannabidiol, 120+ additional cannabinoids and 440+ non-cannabinoid compounds, for human health and disease has become apparent. Approximately 30 years after the elucidation of THC structure the molecular reasons for the biological activity of these plant extracts were made clearer by the discovery of endocannabinoids, that are endogenous lipids able to bind to the same receptors activated by THC. Besides endocannabinoids, that include several N-acylethanolamines and acylesters, a complex array of receptors, metabolic enzymes, transporters (transmembrane, intracellular and extracellular carriers) were also discovered, and altogether they form a so-called ?endocannabinoid system? that has been shown to finely tune the manifold biological activities of these lipid signals. Both plant-derived cannabinoids and endocannabinoids were first discovered by the group led by Prof. Dr. Raphael Mechoulam, who has just celebrated his 90th birthday and clearly stood out as a giant of modern science. The many implications of his seminal work for chemistry, biochemistry, biology, pharmacology and medicine are described in this special issue by the scientists who reached during the last 20 years the highest recognition in the field of (endo)cannabinoid research, receiving the Mechoulam Award for their major contributions. I thank them for having accepted my invitation to be part of this honorary issue of Molecules, and Raphi for continuing to illuminate our field with his always inspiring investigations and new ideas. 517 $aThemed Issue in Honor of Professor Raphael Mechoulam 606 $aResearch & information: general$2bicssc 606 $aBiology, life sciences$2bicssc 606 $aBiochemistry$2bicssc 610 $acannabinoid 610 $aMRI-1867 610 $ahybrid ligand 610 $aCB1 receptor antagonist 610 $aiNOS inhibitor 610 $arimonabant 610 $aintracerebroventricular administration 610 $aalcohol craving 610 $atwo-bottle paradigm 610 $adrinking in the dark 610 $aN-acyltransferase 610 $aanandamide 610 $aendocannabinoid 610 $aphospholipase A2 610 $acannabichromene 610 $acannabidiolic acid 610 $acannabidivarin 610 $acannabidivarinic acid 610 $aphytocannabinoids 610 $atetrahydrocannabivarin 610 $a4'-fluoro-cannabidiol 610 $acannabinoid tetrad 610 $aelevated plus maze 610 $acatalepsy 610 $amarble bury 610 $aHUF-101 610 $aequilibrative nucleoside transporter 610 $aCB1 610 $abiased signaling 610 $afunctional selectivity 610 $aG-protein 610 $a?-arrestin 610 $acannabigerol 610 $aanti-inflammatory 610 $aobesity 610 $acannabinoid receptor 2 (CB2R) 610 $amicroglia 610 $ainflammaging 610 $amemory 610 $alipofuscin 610 $aaminoalkylindole 610 $aallodynia 610 $aantinociception 610 $acannabinoid receptor 610 $aCP55940 610 $aJWH-018 610 $aK2 610 $apravadoline 610 $aspice 610 $aWIN55212-2 610 $atype 1 cannabinoid receptor CB1 610 $acholesterol 610 $ahippocampus 610 $afrontal cortex 610 $asynaptosomes 610 $arescue model 610 $aanti-CB1 antibody 610 $acannabinoids 610 $aGPR55 receptors 610 $aVCE-006.1 610 $achromenopyrazole 610 $aParkinson's disease 610 $a6-hydroxydopamine 610 $alipopolysaccharide 610 $aamyotrophic lateral sclerosis 610 $amSOD1 mice 610 $aTDP-43 transgenic mice 610 $aPPARs 610 $agut microbiome 610 $aintestine 610 $aghrelin 610 $aLEAP2 615 7$aResearch & information: general 615 7$aBiology, life sciences 615 7$aBiochemistry 700 $aMaccarrone$b Mauro$4edt$0313277 702 $aMaccarrone$b Mauro$4oth 906 $aBOOK 912 $a9910566470103321 996 $aA Themed Issue in Honor of Professor Raphael Mechoulam: The Father of Cannabinoid and Endocannabinoid Research$93033960 997 $aUNINA