LEADER 01012nam0-2200325 --450 001 9910559900803321 005 20230327200800.0 010 $a978-88-6542-415-5 020 $aIT$b2016-4914 100 $a20220502d2015----kmuy0itay5050 ba 101 0 $aita 102 $aIT 105 $aa 001yy 200 1 $aCittą meridiane$ela questione metropolitana al Sud$fa cura di Giuseppe Guida$gprefazione di Carmine Gambardella 210 $aNapoli$cLa scuola di Pitagora$d2015 215 $a206 p.$cill.$d21 cm 225 1 $aFabbrica della conoscenza$v55 610 0 $aCittą metropolitane$aPianificazione territoriale$aItalia meridionale 676 $a307.1216409457 702 1$aGambardella,$bCarmine 702 1$aGuida,$bGiuseppe 801 0$aIT$bUNINA$gREICAT$2UNIMARC 901 $aBK 912 $a9910559900803321 952 $aSEZ.NA B 3777$b110/2022$fFARBC 952 $aFL AMM 50$bFL-180$fDECBC 959 $aFARBC 959 $aDECBC 996 $aCittą meridiane$91773039 997 $aUNINA LEADER 02498nam 2200589 a 450 001 9910139690003321 005 20230802004630.0 010 $a3-527-64478-4 010 $a1-283-45422-X 010 $a9786613454225 010 $a3-527-64482-2 010 $a3-527-64479-2 035 $a(CKB)2550000000084138 035 $a(EBL)851166 035 $a(OCoLC)775871780 035 $a(SSID)ssj0000642007 035 $a(PQKBManifestationID)11458699 035 $a(PQKBTitleCode)TC0000642007 035 $a(PQKBWorkID)10628609 035 $a(PQKB)11613742 035 $a(MiAaPQ)EBC851166 035 $a(Au-PeEL)EBL851166 035 $a(CaPaEBR)ebr10531468 035 $a(CaONFJC)MIL345422 035 $a(EXLCZ)992550000000084138 100 $a20120309d2012 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aTherapeutic proteins$b[electronic resource] $estrategies to modulate their plasma half-lives /$fedited by Roland Kontermann 210 $aWeinheim, Germany $cWiley-Blackwell$d2012 215 $a1 online resource (374 p.) 300 $aDescription based upon print version of record. 311 $a3-527-32849-1 320 $aIncludes bibliographical references and index. 327 $apt. 1. General information -- pt. 2. Half-life extension through chemical and post-translational modifications -- pt. 3. Half-life modulation involving recycling by the neonatal Fc receptor -- pt. 4. Half-life extension with pharmaceutical formulations. 330 $aFor this ready reference, the internationally renowned authority in the field, Roland Kontermann, has assembled a team of outstanding contributors from industry and academia to convey the worldwide knowledge on modifying therapeutic proteins in order to optimize their pharmacological potential. The result is a comprehensive work covering all approaches and aspects of the topic in one handy volume, making this indispensable reading for companies and research institutions working on the development of biopharmaceuticals. 606 $aProtein drugs$xDesign 606 $aProteins$xTherapeutic use 615 0$aProtein drugs$xDesign. 615 0$aProteins$xTherapeutic use. 676 $a615.3 701 $aKontermann$b Roland$0941977 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910139690003321 996 $aTherapeutic proteins$92125405 997 $aUNINA