LEADER 04946nam 22006615 450 001 9910559397303321 005 20250411004751.0 010 $a3-030-90924-7 024 7 $a10.1007/978-3-030-90924-6 035 $a(MiAaPQ)EBC6949310 035 $a(Au-PeEL)EBL6949310 035 $a(CKB)21479235800041 035 $a(PPN)262168138 035 $a(DE-He213)978-3-030-90924-6 035 $a(EXLCZ)9921479235800041 100 $a20220406d2022 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aOptimization of Pharmaceutical Processes /$fedited by Antonios Fytopoulos, Rohit Ramachandran, Panos M. Pardalos 205 $a1st ed. 2022. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2022. 215 $a1 online resource (437 pages) 225 1 $aSpringer Optimization and Its Applications,$x1931-6836 ;$v189 311 08$aPrint version: Fytopoulos, Antonios Optimization of Pharmaceutical Processes Cham : Springer International Publishing AG,c2022 9783030909239 327 $aProcess control and intensification of solution crystallization (Gong) -- Method of characteristics for the efficient simulation of population balance models (D. Braatz) -- Linearized parameter estimation methods for modeled crystallization phenomena using in-line measurements and its application to optimization of partially seeded crystallization in pharmaceutical processes (Hirasawa) -- Mathematical modeling of different breakage PBE kernels using Monte Carlo simulation results (Kumar) -- Optimization of tablet coating Mayur M Patel Continuous twin screw granulation processing (Douroumis) -- Continuous powder feeding: Equipment design and material considerations (Crean) -- Ultrasound for improved encapsulation and crystallization with focus on pharmaceutical applications (Gogate) -- Nonsmooth modeling for simulation and optimization of continuous pharmaceutical manufacturing processes (Patrascu) -- Integrated synthesis, crystallization, filtration and drying of active pharmaceutical ingredients: a model-based digital design framework for process optimization and control (K. Nagy) -- Fast model predictive control of modular systems for continuous manufacturing of pharmaceuticals (D. Braatz). -- Dynamic modeling and control of a continuous biopharmaceutical manufacturing plant (Mansouri) -- Overview of scheduling methods for pharmaceutical production (T. Maravelias) -- Model-based risk assessment of mAb developability (Glassey) -- Design framework and tools for solid drug product manufacturing processes (Sugiyama) -- Challenges and solutions in drug product process development from a material science perspective (Stauffer). 330 $aOptimization of Pharmaceutical Processes presents contributions from leading authorities in the fields of optimization and pharmaceutical manufacturing. Formulated within structured frameworks, practical examples and applications are given as guidance to apply optimization techniques to most aspects of pharmaceutical processes from design, to lab and pilot scale, and finally to manufacturing. The increasing demand for better quality, higher yield, more efficient-optimized and green pharmaceutical processes, indicates that optimal conditions for production must be applied to achieve simplicity, lower costs and superior yield. The application of such methods in the pharmaceutical industry is not trivial. Quality of the final product is of major importance to human health and the need for deep knowledge of the process parameters and the optimization of the processes are imperative. The volume, which includes new methods as well as review contributions will benefit a wide readership including engineers in pharmaceuticals, chemical, biological, to name just a few. 410 0$aSpringer Optimization and Its Applications,$x1931-6836 ;$v189 606 $aMathematical optimization 606 $aCalculus of variations 606 $aIndustrial engineering 606 $aProduction engineering 606 $aPharmacy 606 $aCalculus of Variations and Optimization 606 $aIndustrial and Production Engineering 606 $aPharmacy 615 0$aMathematical optimization. 615 0$aCalculus of variations. 615 0$aIndustrial engineering. 615 0$aProduction engineering. 615 0$aPharmacy. 615 14$aCalculus of Variations and Optimization. 615 24$aIndustrial and Production Engineering. 615 24$aPharmacy. 676 $a540.1 676 $a615.19 702 $aFytopoulos$b Antonios 702 $aRamachandran$b Rohit 702 $aPardalos$b Panos M. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910559397303321 996 $aOptimization of pharmaceutical processes$92968873 997 $aUNINA